What Is Collagen and Why Is It so Important? Collagen is a family of fibrous proteins in the body and could be described as the glue that helps hold your body together. Your body actually produces more than 20 different kinds of collagen but only three of them are what make up about eighty to ninety percent of all the collagen present. However, as you age, the production of collagen in your body naturally slows down which causes you to experience the signs of aging and other age related health issues
"a rare genetic disorder of collagen synthesis associated with broad spectrum of musculoskeletal problems, most notably bowing and fractures of the extremities, muscle weakness, ligamentous laxity, and spinal deformities." (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves are also affected to a variable degree. OI has a "common feature of bony fragility associated with defective formation of collagen by osteoblasts and fibroblasts
Cellulite is an aesthetically non - pathological concern that affects more than 85% of females and a minority of males and is not limited to a particular race. In females, cellulite is identified during the post puberty stages of development due to the structural changes the body undergoes and at this point of time can have effects on the individuals self esteem and self consciousness. Cellulite can develop often seen in areas of the upper limbs, abdominal and gluteal regions, and in some cases
body's capacity to make solid bones. In predominant established OI, a man has too little sort I collagen or a low quality of sort I collagen because of a transformation in one of the sort I collagen qualities which makes the bones
In the past decade, the demand of performance from elite athletes has risen drastically. This demand brought about more injuries, in turn increasing the demand for quicker recovery times from surgery or from an acute injury in these top athletes. Doctors have discovered what they believe to be a helpful solution to the problem, Platelet-Rich Plasma Injections (PRP). These injections are to be administered directly into an athlete’s injured tendon. PRP is a process that essentially separates your
that is used by the human body. Just as silicone is often used as a lubricant in various industries, the body uses silica as a lubricant for the connective tissue, or collagen, and arteries. Silica helps the body maintain its flexibility by lubricating the joints. Without silica, the arteries would become less flexible and the collagen levels would be depleted, resulting in wrinkles, hair loss, and brittle nails. In addition to providing arthritis help, it also is necessary in maintaining circulation
Proteins are large molecules that play an integral role in the body’s function. Proteins perform functions in the body such as enzyme catalysis, DNA replication, cell signaling, and transportation of molecules from one location to another. Proteins are made up of smaller units called amino acids, which are made from the 20 amino acids. What makes proteins differ from one another is the specific sequence of amino acids and their three-dimensional structure. There are four distinct structures a protein
There are more than ten inherited disorders within Elhers-Danlos syndrome. Ehlers-Danlos syndrome (EDS) is a “genetic defect in collagen and connective tissue synthesis and structure” (Schwartz, 2013). EDS affects the skin, joints and blood vessels in most types. In EDS the abnormality of the collagen varies dependent on the type of EDS. Six of the main types of Ehlers-Danlos syndrome include; types I and II EDS which are called the classic type, type III hypermobile EDS, type IV vascular EDS, type
Epidermolysis Bullosa is the result of a mutation in the keratin or collagen gene. There are three layers of skin epidermis, dermis and the subcutaneous layers. Epidermolysis Bullosa affects the top two layers. For those who are not affected by E.B. there are protein anchors that prevent the top two layers from moving without unison or shearing. But those who are affected by E.B. lack the protein anchors that are made of collagen. This is what creates the friction between the layers and this rubbing
Osteogenesis Imperfecta- Pathology Paper Osteogenesis Imperfecta is a disease that beginning when one is in the womb. It is a defect in collagen deposition that reduces bones. This disease makes bones very brittle and weak. These weak bones are often developed during pregnancy and will continue to occur throughout childhood. As stated in Access Medicine, Osteogenesis Imperfecta causes “fragility of bones may be severe enough to limit physical activity or be so mild that individuals are unaware of
Herlitz junctional epidermolysis bullosa [107, 141]. Laminin 332 can bind via the G domain to α6β4 and α3β1 integrins [144, 145]. It also has binding sites along its β-chain for laminin 311 and collagen VII [146], and other binding sites along the γ-chain for perlecan and different types of collagen (IV, VII, and XVII) [144, 146]. Several studies showed that laminin 332 is involved in various cellular processes, such as epithelial cell adhesion, spreading and migration [147, 148]. The
surrounded by loose areolar connective tissue called paratenon. The main components of the paratenon are the type I collogen about 95% and about 5% of type II collagen of the dry tendon weight but smaller quantities of other collagens are also present, including types V, VI, XII and type II collagen (Robi et al. 2013). The bundles of collagen fibrils are wrapped in endotenon, which in turn is enveloped by an epitenon, forming the actual tendon. A real synovial sheath is present only in some tendons
which are cumulative and get better over time. It helps you tone and lift your facial muscles back where they belong. After the age of twenty years old, we produce less and less collagen per year. When we reach 60 years old, we produce zero collagen! Microcurrent helps to wake up your skin and start to produce collagen, which helps to reverse the aging process. Not to mention, you can get a nice price for this treatment that should be sold as a package of at least six treatments. With that being
Connective Tissue Connective tissues are found all over our bodies. Generally, they are located in blood, fat, and between muscles and bones. The matrix is the substance that surrounds the cell. Matrices can be fluid or solid, depending on where they are found. They also are found to have varying degrees of vascularity. For example, a bone would be very vascular while cartilage is avascular. Two good property the cells of connective tissue have is that they can divide and repair themselves
EhlersDanlos Syndrome Ehlers-Danlos sydrome (EDS) is a rare inherited group of connective tissue disorders characterized by defects of the major structural protein in the body (collagen). Collagen is a tough fibrous protein that plays an essential role in binding, holding together, strengthening, and providing elasticity to bodily cells and tissues. There are six major types of EDS that I will discuss, however I will only go into detailed discussion on two of the six types of EDS. The two major
UK Gelatin Bovine Spongiform Encephalopathy, or BSE, is a degenerative disease affecting the central nervous system of cattle causing the brain to appear as a sponge. The cattle then begin acting abnormally and eventually have to be killed. BSE can be transmitted to humans if they consume raw meat from an infected cow or if one consumes the eyeballs, spinal tissue, or the brain. This disease is known as Creutzfeldt-Jakob disease. Another disease similar to BSE, which is found in sheep, is Scrapie
together. Without it, the human body could fall apart. It is also the essential part of collagen. Collagen in the skin begins to break down, by the sun, this is photoaging, and then wrinkles appear. When we are young, the body is able to absorb and support high levels of this mineral, so that our bodies stay flexible, energetic and resilient. The benefits of silica are important for connective tissue (collagen formation), development, bone, and cartilage. Silica is the reason children have such
skin disorders. Ehlers-Danlos syndrome is a disorder of the connective tissues that is inherited by a child from their parent. The fragility of the skin and looseness of the joint can often be a result of abnormalities in the genes that produce collagen. It is categorized into numerous primary types. The abnormalities in this connective tissue disorder may cause hyper-extensibility of the skin, delayed bruise healing, fragility in the tissues and hypermobility of the joints. Certain patients with
If you have a dog or a cat at home, have you ever looked at their food’s ingredients list? If you have, you may have noticed that vitamin C is never included in the ingredients. That’s because dogs and cats can make their own vitamin C and don’t have to have supplement through their diet. In fact, pretty much all living organisms on this planet make their own vitamin C except most bats, all guinea pigs, and certain primates, birds and fish. And of course us humans. We have to get our vitamin C through
The disease I am going to discuss in this paper is Heterotopic Ossification (HO). According to Goodman, Fuller, and O’Shea (2012), Heterotopic Ossification is defined as bone formation in nonosseous tissues (forms the rigid part of the bones that make up the skeletal system), and is considered a benign condition of abnormal bone formation in soft tissue. (pg. 666) According to numerous references and medical websites, I have found no known cause of HO. It is presumed by Chao, Suh, & Joyce (2007)