Epidermolysis Bullosa also known as E.B. is generally an inherited connective tissue disease. This disease is evident at birth or soon there after. It causes large fluid filled blisters, in the skin and mucosal membranes. Chaffing or even increase in room temperature may cause these blisters to form. E.B. affects an estimated 50 in 1 million live births. The disease has been known to affect every racial and ethnic group and is found in both males and females all over the world. The disease has been seen in a wide variety of forms from mild to lethal form involving some organs. Epidermolysis Bullosa is the result of a mutation in the keratin or collagen gene. There are three layers of skin epidermis, dermis and the subcutaneous layers. Epidermolysis Bullosa affects the top two layers. For those who are not affected by E.B. there are protein anchors that prevent the top two layers from moving without unison or shearing. But those who are affected by E.B. lack the protein anchors that are made of collagen. This is what creates the friction between the layers and this rubbing and pressure causes the painful blisters and sores which have been compared to third degree burns. There are four main types of Epidermolysis Bullosa: Dystrophic Epidermolysis Bullosa, Epidermolysis Bullosa simplex, Hemindesmosomal Epidermolysis Bullosa and Junctional Epidermolysis Bullosa. Even within the main types there are many sub types including Epidermis Bullosa Acquisita generally appearing in adults over the age of 50. This specific type is also linked to Cohen’s disease and Lupus.
A doctor may suspect Epidermolysis Bullosa by the appearance of your skin but many tests must be performed on a patient to fully diagnose the disease. Many te...
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...and crystal skin children according to some articles. Due to the fact this disease is inherited there is no way of preventing the birth of someone with Epidermolysis Bullosa. Genetic counseling is an option for parents with a family history of Epidermolysis Bullosa. To prevent any current skin trauma or blistering in Epidermolysis Bullosa it helps to wear padding around areas they are prone to trauma and contact sports should be highly avoided. Many different medications may be prescribed steroids being one of them. Calcium and vitamin d are supplements also used in treatment. Living with this disease may be painful and complicated but with proper care and knowledge of your specific type of Epidermolysis Bullosa you may be able to live a long life.
SOME EXAMPLES OF THE VARIETY OF SEVERITY FOUND IN EPIDERMOLYSIS BULLOSA
Arch Dermatol. 2007;143(1):124–125. Puchenkova, S. G. (1996). "
When microdermabrasion removes the outer layer of skin the body then goes into a healing mode that promotes the making of new healthier cells. Microdermabrasion is like when one sustains an injury to his skin and the body sends treatment molecules to heal the damage. Mariane Fernandes conducted an experiment with the aim to evaluate the effects of microdermabrasion on skin rejuvenation. Fernandes stated in her article “Effects of microdermabrasion on skin rejuvenation” in the Journal of Cosmetic and Laser Therapy that “Microdermabrasion treatment promoted skin rejuvenation through an increase in skin thickness due to an increase in epidermal thickness and collagen organization” (Fernandes 26). Acne weakens and thins the skin epidermal layers, causing acne scars. Microdermabrasion heals the weak, thin, and fragile skin, which makes the skin smooth and more resistant to other damaging conditions. Doctor Bruce M. Freedman an aesthetic plastic surgeon and assistant professor of plastic surgery at Georgetown University also analyzed the dermatological changes associated with microdermabrasion in “Clinical and histologic changes determine optimal treatment regimens for microdermabrasion” in the Journal of Dermatological Treatment. Freedman’s experiment also yielded results of an increase of epidermal thickness
Puttaraju, G. H. and Visveswariah, P. M. 2013. Ectodermal dysplasia in identical twins. Journal of pharmacy & bioallied sciences, 5 (Suppl 2), p. 150.
Xeroderma Pigmentosum is a genetic disorder caused by a mutation in one of any seven genes. This genetic mutation is an autosomal recessive trait. This disease was discovered in 1874 by Hebra and Kaposi. People with this disease cannot have direct exposure to sunlight, or blisters on the skin may occur. There are only about 250 people in the world with this disease.
What are these red patches of skin on my body that I can’t ever help from scratching? It is eczema, which is defined as a medical condition in which patches of skin become inflamed, with blisters that cause itching and bleeding. Genetics take a role in the possibility of having eczema, after comes the diagnosis, then being prescribed the treatment needed, and lastly their prognosis.
Impetigo is a bacterial skin infection characterized by the eruptions of superficial pustules and formation of thick yellow crusty sores. It is highly contagious and can occur anywhere on the body, especially in exposed areas. The two different types of Impetigo are Bullous Impetigo, which are large blisters, and Non-Bullous Impetigo, which are crusted over blisters. Non-Bullous Impetigo is the most common type. Both types require contact precautions because they can be transmitted via physical contact with anyone who has it, sharing the same clothes, bedding, towels, etc... Because of the way young children proceed with their lifestyles, touching everything within their reach, the primary age groups targeted with this infection are, in fact, young children. It is most common on their facial area, mainly around their noses and mouths, but sometimes impetigo will appear on their arms and legs.
“Basal cell carcinoma is an uncontrolled, abnormal growths or lesions that arise in the skins basal cells, which line the deepest layer of the epidermis.” (Phillip, 2011) Basal cell carcinoma often times resembles open sores, red patches, shiny bumps or scars. Majority of basal cell carcinoma cases occur on parts of the body such as the face, ears, neck, scalp, shoulders and back that are excessively exposed to the sun.
Chernecky, C. C., and B. J. Berger. Laboratory tests and diagnostic procedures. 5. St. Louis MO: W B Saunders Co, 2008. eBook.
If your child gets Apert Syndrome they may have many physical defects as well as a few other problems such as slower learning, a cleft palate, vision problems, and problems with acne during puberty. I don’t think Apert Syndrome children die, expecially because you can pass Apert through genetics. A child with Apert Syndrome could live a pretty normal life.
The second layer of the skin is called the dermis and is also known as the middle layer. The dermis is what holds the body together. The dermis has layers to it as well as the epidermis. There are two layers to the dermis, the papillary layer and the reticular layer. The cells of the dermis are fibroblast, macrophages, mast cells, and scattered white blood cells (wbc’s). the dermis is richly supplied with nerve fibers and BV;s. dermal BV’s is also a part of the integumentary system, dermal BV,s have converging and diverging vessels that ar...
The epidermis, which is the outer layer of the skin, is made up of four to five layers in some parts (Shier, Butler, & Lewis, 2009). In the majority of the areas, just four layers can be differentiated: the stratum basale, stratum spinosum, stratum granulosum, and stratum corneum (p.119). Another layer is the stratum lucidum which can be found in the thicker part of the skin of the palms and ...
Most parents remembered hearing about the importance of protecting their children from the sun, yet children are still playing in the sun without sunscreen or protective clothing. Many people these days are not taking skin cancer seriously after knowing its significance. Skin cancer has been a growing problem in the United States and millions of people have suffered from it every year. The three most common skin cancers are Melanoma, Basal cell, and Squamous cell, which can cause bumps, sores, growths, etc. Skin cancer is a deadly disease with many causes, but the advantage is that it can be prevented.
The word melanoma comes from the Greek words, melas (black) and -oma (tumour). It is a very serious cancer that most often occurs in the skin and less frequently in the eye or in the lining of the nose, mouth, or genitals. Melanoma begins in melanocytes, cells that make a pigment called melanin. Both light- and dark-skinned people have melanin, which gives colour to the skin, hair, and parts of the eye.
Cardiofaciocutaneous syndrome is a very rare and serious genetic disorder that generally affects the heart, facial features, and skin of an individual. It is caused by a desultory gene mutation, which takes place in one of four genes. Those genes are known as BRAF, MEK1, MEK2, and KRAS. From research, it is also suspected there is a possibility that other genes are associated with the rare condition. This disorder holds multiple alternative names, a long history, obvious symptoms, extensive amounts of interesting data, and is lucky enough to be supported by numerous organizations that will stop at nothing to help.
Psoriasis is a chronic skin disorder, easily identified by its symptoms of white, scaly skin and red lesions, though not so easily cured or understood. In psoriasis, skin cells mature faster than the body can shed them, causing a buildup. Although there are many theories as to what the cause of such a disease might be – genetics, stress, or other triggers – no one is quite sure why the disease occurs, or what could be a possible way to fully cure it. In this essay we will explore the symptoms, types, and effects of this condition, and also some of the known treatments.