Osteogenesis Imperfecta Paper

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Osteogenesis Imperfecta- Pathology Paper
Osteogenesis Imperfecta is a disease that beginning when one is in the womb. It is a defect in collagen deposition that reduces bones. This disease makes bones very brittle and weak. These weak bones are often developed during pregnancy and will continue to occur throughout childhood. As stated in Access Medicine, Osteogenesis Imperfecta causes “fragility of bones may be severe enough to limit physical activity or be so mild that individuals are unaware of any disability”(Prockop Online). While levels of intensity of the disease can vary, severe forms have only a limited amount of reports. Osteogenesis Imperfecta “has a frequency of about 1 in 15,000–20,000 births”(Prockop). This disease focuses on …show more content…

Since there is no definitive test, one must look at easy bone breaking to test for the possibility of the disease. Just like there is no test for Osteogenesis Imperfecta there is also no cure at this time. Things such as physiotherapy to help strengthen the muscles can help with a patient’s mobility. “Physiotherapy and hydrotherapy focused on muscle strength and joint range of motion are crucial to maximize an individual's function and independence”(Forlino). While therapies are the most affective way of treatment, there are also medications one can be prescribed to help with Osteogenesis Imperfecta. The most common type of medication is known as the drug, Bisphosphonates. “Bisphosphonates are deposited on the surface of bone, where their endocytosis by precursor or mature osteoclasts induces cell death (apoptosis). Thus, treatment aims to increase bone volume by counteracting the high turnover cellular status of bone in classic osteogenesis imperfecta”(Forlino).
While there is still not cure for Osteogenesis Imperfecta, science continues to advance where more discoveries are coming out about the disease itself. Scientific studies have been preformed to test different variables to help find remedies for a

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