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Malnutrition effects on the body
Related literature review on malnutrition
Enzymes general bio
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Recommended: Malnutrition effects on the body
Introduction:
Enzymes are essential to the proper functioning of the human body. Enzymes are catalysts, which cause reactions to occur. The two primary classes of enzymes for maintaining life functions are digestive and metabolic enzymes. The primary digestive enzymes are classified as proteases, amylases and lipases. These enzymes can help breakdown food molecules. Metabolic enzymes are responsible for the repairing and structuring of every cell. Inadequate production of digestive enzymes can have a negative impact on the breakdown of food into the various nutrients our bodies require.
Problems associated with Celiac Disease and Lactose Intolerance
“Celiac disease is an inflammatory disease of the upper small intestine caused by intolerance to gluten.” The small intestine has an inner lining of cells which contain villi (Marks). The substance, known as gluten damages the villi which line the small intestine. When the villi are damaged or inflamed, they are unable to absorb water and other essential nutrients. These nutrients can contain substances such as iron, calcium, vitamins, and folic acid. The healthy and damaged villi can be observed in figure 1. The healthy villi are able to absorb the essential nutrients that they need to function efficiently. The inflammation caused in people with celiac disease, destroys their villi which causes the inner lining of the small intestine to be compressed (Marks). Due to the damaged lining of the small intestine, digestive enzymes which are essential for the complete breakdown of various foods are unable to be produced. This can cause a person to be malnourished. Therefore, the food remains in the digestive tract unabsorbed, as it is fermented by bacteria. This causes bloating and var...
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"ENZYMES Digestion Aid." NATURAL THERAPY INFORMATION Energy Healing Alternative Therapies Health Wellness Liquid Zeolite. 2006. Web. 18 Oct. 2010. .
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Jackson, Frank W. "Lactose Intolerance." Jackson Siegelbaum Gastroenterology. 2008. Web. 18 Oct. 2010. .
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LI was first recognized in the 1960s when researchers found black children responding unfavorably to milk in their diets (Harrison 812). Research led to the discovery that lactose, the major sugar in milk and related dairy products, was undigestible in some people because they were missing the enzyme lactase. Lactase breaks down lactose into its component monosaccharide sugars, glucose and galactose. In people missing lactase, lactose passes undigested through the small intestine. In some people, the undigested lactose passes through the remainder of their systems with no ill effects. In others, however, the undigested lactose becomes viscous and ferments in the colon (Englert and Guillory 903). The thickness of the liquid and the fermentation cause painful cramping, gas and sometimes diarrhea. Besides not being able to digest lactose, these people suffer from malabsorption, which causes them to receive little or none of milk's nutrients (Houts 110).1
Proteins are one of the main building blocks of the body. They are required for the structure, function, and regulation of the body’s tissues and organs. Even smaller units create proteins; these are called amino acids. There are twenty different types of amino acids, and all twenty are configured in many different chains and sequences, producing differing protein structures and functions. An enzyme is a specialized protein that participates in chemical reactions where they serve as catalysts to speed up said reactions, or reduce the energy of activation, noted as Ea (Mader & Windelspecht).
Celiac Disease is an inflammatory disease that destroys the lining of the small intestines and prevents the absorption of nutrients and vitamins into the system. The patients' health suffers; their digestive system is unable to process gluten foods that contain wheat, barley, and oats. The cause of this disease is unknown; however, environmental factors and a genetic predisposition are suspected.
Celiac Sprue also known as celiac disease is a chronic disease of the digestive tract that interferes with the digestion and absorption of nutrients from food. (Mohaumed Wehbi, MD) also Celiac Sprue is an immune reaction to eating gluten a protein found in wheat, barley and rye. Due to the intestinal damage and malabsorption celiac sprue can reduce the quality of life due to diarrhea, fatigue weight loss, bloating, and anemia. The lining of the intestine contains essential enzymes for the absorption and digestion, its destruction leads to malabsorption, a difficulty in absorption of food and essential nutrients.
Enzymes are biological catalysts - catalysts are substances that increase the rate of chemical reactions without being altered itself. Enzymes are also proteins that fold into complex shapes that allow smaller molecules to fit into them. The place where these substrate molecules fit is called the active site. The active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of residues that form temporary bonds with the substrate and residues that catalyse a reaction of that substrate. (Clark, 2016)
Celiac disease is when the lining of the small intestine is damaged due to ingesting foods that contain gluten (WebMD, 2014). It is an autoimmune disorder which means, that the body attacks healthy cells and tissues by mistake. The body forms antibodies to gluten and this causes the attack on the small intestine. As a result, inflammation occurs and this damages the microvilli hairs within the small intestine (WebMD, 2014). Without villi, nutrients can no longer be absorbed. Gluten is a protein and is found in all grains except for corn and rice (Hoehn & Marieb, 2013, p.898). It is often found in foods such as anything with wheat, cookies, cakes, donuts, pizza, muffins, rye, and sometimes canned soups (Celiac Disease and Gluten sensitivity, 2014). Gluten can also be found in products. Medicines, lip balms, and vitamins are all products that gluten may be found in (NDDIC, 2012). As I explained, the small intestine is damaged as a result of celiac disease. The small intestine plays a big role in absorbing nutrients. Damage to the small intestine results in lack of nutrient absorption. Some of the nutrients included are fats, calcium, and iron (WebMD, 2014). This can become a serious issue and must not be left unattended. It can lead to the onset of other diseases such as neurological disorders, other immune disorders, and cancer (NFCA, 2014). Often times when one family member has celiac disease, other immediate family members have it as well. Celiac disease can affect anyone, no matter their age, race, or gender. About 1 in every 100 people has celiac disease (Hoehn & Marieb, 2013, p.898). This is equivalent to about 1% of the population nationally. There is no particular demographic group that is affected.
Gluten is a protein found in common grains such as wheat, barley, and rye. Those affected with allergies to these foods (the most serious allergy being Celiac Disease) must follow a strict gluten-free diet in order to experience relief from their symptoms. Despite eliminating the ingestion of the allergen, gluten-free individuals begin to suffer from adverse side effects. In recent years, many Americans have begun to live an entirely gluten-free lifestyle with no medical necessity to do so. Many believe it to be a healthier diet, and even more believe it is an effective weight-loss tool. With this growing fad of adopting a gluten-free diet, under the false pretenses of varying health benefits, many Americans are exposing themselves to unnecessary health risks, over-priced and narrowly available foods, and an overall depletion of dietary needs.
The definition of Celiac disease is a common inflammatory disease of the small bowel that is precipitated by the consumption of foods that contain gluten. But Celiac disease is an autoimmune disease that the small intestine is hypersensitive to gluten, which leads to the difficulty of digesting food. This condition damages the lining of the small intestine and prevents it from absorbing nutrients from parts of food that are important for being healthy. The damage is due to a reaction to eating gluten, which is found in wheat, barley, and rye.
A selective advantage of not producing lactase as an adult is simply saving energy for the body to use elsewhere. Young children need dairy products which contain lactose because it helps their bodies grow by providing healthy nutrients like fats, proteins, vitamins and it also helps make their bones stronger. As children grow older in to young adults their bodies are less inclined to need the large amount of nutrients the dairy products provide. Since the body no longer feels the lactose is a helpful source, the body slowly decreases the amount of lactase enzymes being produced. Typically a young adult can still comfortably have a glass of milk but the body progressively decreases the amount of lactase enzymes being produced. These lactase enzymes are what break down lactose and simple sugars. Once the body can no longer do this, a person will struggle digesting dairy products. This is a selective advantage because it helps the body save energy, instead of wasting it on producing these lactase enzymes. The body does not need lactose anymore so other...
... Medicine. 3rd ed. Vol.3. Detroit: Gale, 2006.2139-2141. Gale Virtual Reference Library. Web. 3 Apr. 2014.
When food containing the gluten protein arrives in the small intestine, the immune system reacts against the gluten, causing an inflammatory reaction. 1. The small intestine lining is covered by millions of villi, finger-like projections, which act to increase the surface area of the intestine allowing increased absorption of nutrients. 2. The villi are damaged by the inflammation in celiac disease, which results in a decrease in the absorption of food.
Lactose Intolerance Lactose intolerance is the inability to digest significant amounts of lactose, the predominant sugar of milk. This inability results from a shortage of the enzyme lactase, which is normally produced by the cells that line the small intestine. Lactase breaks down milk sugar into simpler forms that can then be absorbed into the bloodstream. When there is not enough lactase to digest the amount of lactose consumed, the results, although not usually dangerous, may be very distressing.
Madar, Sylvia S., & Windelspecht, Michael. (2014). Inquiry into Life, Metabolism: Energy & Enzymes (pp. 104-107). New York: McGraw Hill.
Enzymes are protein molecules that are made by organisms to catalyze reactions. Typically, enzymes speed up the rate of the reaction within cells. Enzymes are primarily important to living organisms because they help with metabolism and the digestive system. For example, enzymes can break larger molecules into smaller molecules to help the body absorb the smaller molecules faster. In addition, some enzyme molecules bind molecules together.
The exocrine function of the pancreas is that it produces enzymes that aids in the digestion of food. There are three important enzymes that are crucial in helping with digestion. The first digestive enzyme is amylase. Amylase function is to break down carbohydrates. The amylase enzyme is made in two places: the cells in the digestive tract that produces saliva and the main one specifically found in the pancreas that are called the pancreatic amylase (Marie, Joanne; Media Demand, “What Are the Functions of Amylase, Protease and Lipase Digestive Enzymes”). The amylase in the pancreas passes through the pancreatic duct to the small intestines. This amylase in the pancreas completes the process of digestion of carbohydrates. Consequently, this leads to the production of glucose that gets absorbed into the bloodstream and gets carried throughout the body. The next enzyme that aids in digestion of food is protease. While amylase breaks down carbohydrates, protease breaks down protein. Protease breaks down protein into the building block form of amino acids. The three main proteases that it produces are: pepsin, trypsin and chymotrypsin (Marie, Joanne; Media Demand, “What Are the Functions of Amylase, Protease and Lipase Digestive Enzymes”). Pepsin does not occur in the pancreas but it is the catalysis in starting the digestion of proteins. Trypsin and chymotrypsin are the two proteases that occur in