There are two main types of genes that play a role in cancer: oncogenes and tumor suppressor genes. Proto-oncogenes are regular genes that can become oncogenes if mutated and an oncogene is a gene that can lead to a tumor when mutated because it causes cells to divide unrestrainedly (Heidi 2008). On the contrary, tumor-suppressor genes slow down cell division. When tumor-suppressor genes do not function properly, cells can grow as rapidly as an oncogene (Heidi 2008). Tumor-suppressor genes involve the BRCA1 and BRCA2 genes that are found in breast cells (Klugar & Park 2013). Certain mutations in each can increase the risk of ovarian or pancreatic cancer (Klugar & Park 2013).
Most breast cancers are inherited, but they can also be acquired. Unlike proto-oncogenes, the American Cancer Society’s article on cancer states that most of the tumor-suppressor gene mutations are acquired instead of inherited. Acquired mutations of the TP53 gene code for the p53 protein and they appear in a variety of cancers, such as lung and breast cancer ("Oncogenes, tumor suppressor," 2011). Cells with damaged DNA continue to divide and eventually leading to cancer if the gene for the p53 protein is not properly functioning ("Oncogenes, tumor suppressor," 2011).
The risk of having breast cancer increases when there is a family history of breast cancer. For example, a woman who has a sister or mother with breast cancer is more likely to develop the disease herself because the genetic mutation is inherited (Klugar & Park 2013). According to the American Cancer Society, 5% to 10% of all cancers are from hereditary mutations. This means that some people are more likely to develop cancer than others because they are born with mutations in their genes.
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...rease to save her own life and that is by having a double mastectomy. But before having a double mastectomy, a woman should consider trying different cancer preventions and if they do not have much affect, then rely on prophylactic surgery as a final option.
If one of my family members found out that she had an increased risk of breast cancer, then I would recommend for her to try the anticancer drug tamoxifen first to see how much it reduces her risk. If there were not much of a decrease, then I would recommend prophylactic mastectomy because it gradually reduces the risk of developing cancer. The National Cancer Institute states that prophylactic mastectomy reduces the risk of breast cancer by at least 95% in women who have an acquired mutation in the BCRA1 ore BCRA2 gene and by 90% in women who have a family history of breast cancer ("Surgery to reduce," 2013).
Women who inherit a mutation in one copy of BRCA1 or BRCA2 are at high risk of developing breast and ovarian cancers6. This could be due to the disruption in the pathway of BRCA proteins in the cell nucleus. If BRCA1 is defective, it loses its ability to fix damaged DNA and causes tumor. It is because once the defective BRCA1 raises, it allows the cells to develop and divide uncontrollably. Since defective in BRCA1 causes cancers, it is important to understanding the function of the protein by analyzing its sequence and structure.
...ves the entire breast and the nipple while leaving the pectoral muscles and axillary lymph nodes intact. This surgery has reduced the occurrence of breast cancer by 90%.
At this point in time, scientists and doctors have yet to discover the specific causes for breast cancer. However, what is known are the different risk factors that may trigger or put women more at danger of acquiring this disease. Aged women who have experienced menopause are more vulnerable at containing this disease. Women are also more at risk if breast cancer is common within their family because it is hereditary. In addition, smoking and drinking are other factors that can put women at risk as well (Stephan, 2010). Obesity in particular is a huge risk factor. Women who are overweight, especially those who have a thicker upper body, are more likely to develop malignant cancers in the breast than a healthy woman (Vona-Davis and Rose, 2009).
Every woman has her own reasons behind her decision to get breast implants. Some women have undergone mastectomies, and get breast implants in order to feel “normal” again. According to the National Women’s Health Network (http://www.womenshealthnetwork.org) women who have lumpectomies have the same survival rate of women who have mastectomies as a result of breast cancer. They concluded that up to 40 percent of women who were diagnosed with breast cancer underwent unnecessary mastectomies. These mastectomies, whether necessary or not may lead to women to undergo breast augmentation surgery.
...st has 3-4 fold risk of developing new cancer in the other breast this is different from a recurrence of first cancer. “Overall, white women are slightly more likely to develop breast cancer than African Americans women.” 5-10 percent of breast cancer is caused by inherited genetic mutations. “2-5 percent caused by inherited mutations in BRCA 1 and BRCA 2 genes”. High doses of radiation, such as treating the disease, in women under 30 shows the higher increased risk for breast cancer.(2) Having a risk factor, or even several, doesn’t mean that you will get the disease. If you are overweight the connection between that and breast cancer risk is complex about 25 percent. “You will need to exercise as little as 1.25 to 2.5 hours per week of walking reduced the breast cancer risk by 18 percent”.(2) High fat diets is a high risk that causes breast cancer 50 percent exact.
Thought to be an oncogene, a gene that has potential in transforming normal cells into tumor cells, p53 was regarded as the most prominent tumor suppressor gene [1]. P53 is a gene which signals apoptosis (programmed cell death) if a cell cannot be repaired due to an extensive amount of damage. As stated in the textbook, p53 regulation occurs by an E3 ubiquitin-protein ligase known as MDM2 [1]. "Controlling the controller" is a statement that describes the molecular interaction where the presence of MDM2 targets the p53 for proteosome via degradation. With three main checkpoints in cell cycle, the literature states p53 functioning from G1 into S phase in a chaotic cell [2]. The normal state of cells is to keep p53 levels low in order to prevent uncontrolled apoptosis and random cell cycle arrest from occurring. In a further note, although p53 promotes apoptosis and cell cycle arrest, cancer may result from p53 unable to recognize the problematic site. In turn, a mutation in p53 may result engaging in new activities. These activities include cellular transformation, tumor metastasis,...
There are numerous risk factors for breast cancer. Genetics or family history of breast cancer in a one first-degree relative with breast cancer doubles a woman’s risk. Having two first degree relatives rises a woman’s risk by three times. A person’s personal history who have had one breast with cancer is three to four times as likely of developing a new cancer. White women are slightly more likely to develop breast cancer than are African-American women, but African-American women are more likely to die from this cancer. However in women under 45 years of age, breast cancer is more common in African-American women.
My sister, Kathy, was diagnosed with cancer in 2013. I was shocked because my sister was always the healthy one among all us girls, the type of cancer, Kathy called colon cancer, Cancer that forms in the tissues of the colon. Most oncogene mutations of indisputable normal genes designate proto-oncogenes. Proto-oncogenes determine the “excellent” genes that usually rule what cell do and the way typically it distribute. Once a factor mutates (changes) into cell, it come back a "hurtful" factor that may become usefulness on or activated once it's not believe to be. Once this occurs, the cell becomes out of management, which might pass to cancer. As scientists learn additional throughout oncogenes, they will be powerful to develop a medication that inhibits or restrain them.
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...
Breast Cancer, as well as other forms of cancer, scientists do know how it occurs, but they do not know an exact cause. There are some genes in our body called oncogenes, genes that have potential to cause cancer, that increases the speed of cell division while other genes such as tumor suppressors, cause the cells to die at the correct time. Mutations that occur in the DNA, which “turn on” the oncogenes or “turn off” tumor suppressor genes, will cause some of the cells to be cancerous in the breast("American Cancer Society"). Also, Breast Cancer can be increased by inherited gene mutations and acquired gene mutations. The risk of Breast Cancer can be increased dramatically, through the inheritance from parent to offspring, if a mutation occurs. For example, if a suppressor gene, such as BRCA, forms a mutation, then it is likely to be passed to future generations. This gene no longer suppresses abnormal growth, therefore there is a higher chance of cancer being developed. Even though Breast Cancer can be inherited it is more likely to be acquired through one breast cell. The acquired mutations could be a result of of radiation or cancer-causing chemicals. ...
25% of the deaths h in 1991 and is the most common cause of death
The cancer cells from gene-mutation. Scientists now know some of the risk factors for lung cancer can cause certain changes in the DNA of lung cells. These changes can lead to not normal cell growth and, sometimes, cancer. DNA is the chemical in each of our cells that makes up our genes and how our cells function. People usually look like their parents because they are the source of our DNA. But DNA affects more than how we look; it also can affect our risk for developing certain diseases, including some kinds of cancer like lung cancer etc…Some people inherit DNA mutation from their parents that greatly increase their risk for developing certain cancers.
Cancer develops when cells in a part of the body begin to grow out of
These oncogenes cause cancer because they do not allow the cells to self-destruct or become epistatic. There have been several research projects which have been testing epistatis. Transfecting DNA To perform the experiments for this research, the researchers had to grow certain pieces of DNA.... ... middle of paper ...
Patients who get the cancer removed and take care of themselves after, for example, by exercising and eating healthy, will live longer. There are many risks that increase the likelihood of developing breast cancer, for instance, age, family history, and race. A woman who made history with breast cancer was Betty Ford, Betty was one of the first lady’s to speak openly about her disease. Betty encouraged women who have been affected by the disease to go to their doctor as soon as possible and told women who had shared that they didn’t have breast cancer to do self breast exams regularly and get mammograms. She also said when women get diagnosed with it, don’t be embarrassed.