Sickle Cell Disease In Red Blood Cells
explanatory Essay
687 words
Sickle cell disease is a blood disorder that affects the red blood cells. This disease is inherited from parents and can be carried as a sickle cell trait. Individuals with this disorder have red blood cells that are sickle-shaped. Due to the shape of this cell, blood does not flow throughout the body as it should. This insufficient blood flow can cause serious damage to tissues and organs. An important part of a normal red blood cell is hemoglobin. Hemoglobin helps red blood cells carry oxygen from our lungs to the rest of our body. Individuals with sickle cell disease form a different hemoglobin than the normal hemoglobin A. These individuals create a form of hemoglobin A, called hemoglobin S, (About SCD & SCT, 2015). There is currently no cure for this disease. …show more content…
In this essay, the author
- Explains that sickle cell disease is a blood disorder that affects the red blood cells, and that there is currently no cure for this disease.
- Explains that sickle cell anemia is a genetic disorder that is passed on from parents like physical trait.
- States that sickle cell disease originated in africa and was brought into the united states through slave trade. it spread to southern europe, middle east, india, and sri lanka.
- Explains how occupational therapy can be beneficial to someone with sickle cell disease. the study participants suffered from chronic pain, eye problems, multiple hospitizations, swelling in the extremities, and developmental delays.
- Opines that the affordable care act, passed by the supreme court, has helped those with sickle cell disease by ensuring that they have health insurance to cover preventative care and health services specific to their needs.
It is a genetic disorder and is passed on from parents like a physical trait would be passed on. The hemoglobin genes are inherited in two sets; one set from the mother and the other from the father (About SCD & SCT, 2015). If one parent as sickle cell and the other doesn’t, nor carries the trait, all of their offspring will be a carrier. If one parent has sickle cell and the other carries the trait, there is a fifty percent chance their offspring will have sickle cell. If both parents carry the sickle cell trait, their offspring will have a twenty-five percent chance of having sickle cell disease (About SCD & SCT, 2015). A blood test is all that is needed for individuals to find out if they carry the sickle cell trait or
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- Sickle Cell Anemia and Red Blood Cell Physiology Introduction Sickle cell anemia is a disorder in which the body makes crescent-shaped red blood cells. Normal red blood cells are disc-shaped. They move easily through your blood vessels and contain an iron rich protein called hemoglobin. This protein carries oxygen from the lungs to the rest of the body. Sickle cells contain abnormal hemoglobin due to a mutation in the hemoglobin chain.
In this essay, the author
- Explains that sickle cell anemia is a disorder in which the body makes crescent-shaped red blood cells and contains an iron rich protein called hemoglobin.
- Opines that sickle cell research is a great thing for patients with sickle cell anemia.
- Explains that in 1990, sickle cell anemia was identified as a cause of death for many children in connecticut. the screening program and follow-up care methods helped reduce the mortality of children.
- Describes how atomic force microscopy is used to measure mechanical properties of living and fixed cells. the rate of deformation of a red blood cell was examined mathematically to define abnormal cell rheology behavior.
892 wordsRead More - Sickle Cell Anemiaexplanatory essaySickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
In this essay, the author
- Explains that sickle cell anemia is a hereditary disorder that affects people of african ancestry, but also occurs in other ethnic groups.
- Explains that sickle cell anemia affects hemoglobin, a protein found in red blood cells that helps carry oxygen throughout the body.
- Explains that teenagers with sickle cell anemia may develop jaundice (pronounced: jon-dis), a condition that results from the high rate of red blood cell breakdown.
- Explains that there is no cure for sickle cell anemia, and it is possible for some people to die. doctors can provide treatments that help prevent complications from the disease.
1107 wordsRead More - Sickle Cell Cause Diseaseexplanatory essaySickle-cell anemia is an illness in which the shape of red blood cells is altered to a sickle-like shape (Peachley, n.d.). It is basically the sickling of erythrocytes. The protein molecule, hemoglobin, is the reason for this altered shape. Hemoglobin is found on red blood cells and it is used to provide oxygen to tissues (Peachley, n.d.). In sickle-cell anemia the altered shape of the red blood cells prevent them from passing through blood vessels and this will result in an inadequate amount of oxygen being delivered to tissues in the body (Peachley, n.d.). Sickle cell anemia was discovered because of gel electrophoresis, which is a method that evaluates the charges of the hemoglobin. Gel electrophoresis, the inheritance pattern, and hemoglobin
In this essay, the author
- Explains that the shape of red blood cells is altered to a sickle-like shape, and the protein molecule, hemoglobin, is the reason for this altered shape.
- Explains how gel electrophoresis was used to determine the difference between sickle cell hemoglobin (hbs) and regular hba.
- Explains that sickle cell anemia is caused by a point mutation, which changes the nucleotide called glutamic acid into valine.
- Explains that the two beta globin alleles are influential considering the genetics of sickle-cell anemia, since it is a recessive trait, the only way for an individual to express this disease is by being homozygous.
- Explains that hemoglobin is an important part of the sickle cell disease. it is a protein that delivers oxygen to tissues in the body.
- Explains that having sickle cell disease alters the structure of hemoglobin.
- Explains that the hemoglobin beta chain, which is not complexed with oxygen, adheres to other beta chains, thus polymerizing.
- Explains that valine is nonpolar and hydrophobic, while glutamate is polar, and is hydrophilic. the altered amino acid of each beta chain causes polymerization into long stiff fibrils.
- Explains that there are a few methods being considered in order to treat sickle cell anemia. one method is to reignite the production of fetal hemoglobin.
- Concludes that sickle cell anemia is a dangerous molecular illness, which results in decreased oxygen levels for the individuals who have it.
1978 wordsRead More - Sickle Cell Anemia Essayexplanatory essaySickle cell anemia affects millions of people around the world, with about 70,000 Americans inheriting the disease, and many others carrying the sickle cell trait (Genetics). This disease mostly affects people that have African and Mediterranean roots, mostly because this disease provides protection for people from malaria which kills 3,000 African children daily (Malaria). Malaria is a deadly infectious disease that is transmitted by to humans when mosquitoes sting them (Learn). Sickle cell anemia is the most common blood disorder that is a result of a mutation in the genes causing a mutated form of hemoglobin, the protein that helps red blood cells transport oxygen to the body from the lungs. The mutated form of hemoglobin, hemoglobin S, causes the red blood cells to alter their shape into a fragile crescent or sickle shape, which is the main cause for any negative effects a person with sickle cell anemia might have.
In this essay, the author
- Explains that the sickle cell shape causes the red blood cells to hit the wall of the blood vessels that surround them, and the connective tissue becomes blocked, damaged and scratched.
- Explains that sickle cell anemia affects millions of people around the world, with about 70,000 americans inheriting the disease, and many others carrying the sickle cell trait.
- Explains that in sickle cell disease, the hbb gene that encodes the beta globin gene on chromosome 11 is mutated creating a point mutation.
- Explains that if the tissues aren't receiving blood, organs like the heart, spleen, kidneys, and lungs will become damaged. people with sickle cell anemia are prone to infections and sickness.
1969 wordsRead More - Sickle Cell Disease Essayexplanatory essayINTRODUCTION — Sickle cell disease (SCD) is an inherited group of disorders characterized by the presence of hemoglobin S (HbS), either from homozygosity for the sickle mutation in the beta globin chain of hemoglobin (HbSS) or from compound heterozygosity of a sickle beta globin mutation with another beta globin mutation (eg, sickle-beta thalassemia). The hallmarks of SCD are vasoocclusive phenomena and hemolytic anemia. Sickle cell trait is a benign carrier condition characterized by heterozygosity for the sickle hemoglobin mutation.
In this essay, the author
- Explains that sickle cell disease is an inherited group of disorders characterized by the presence of hemoglobin s (hbs). the hallmarks of scd are vasoocclusive phenomena and hemolytic anemia.
- Explains that hbs polymerization is a primary determinant of the severity of sickle cell disease (scd).
- Explains that the use of prophylactic penicillin and comprehensive medical care have reduced the mortality of scd during the first five years of life.
- States that screening for scd in newborns is mandated in all 50 states and the district of columbia, regardless of birth setting.
- Explains that scd diagnosis should utilize dna testing or be postponed for at least four months after transfusion.
2387 wordsRead More - sickle cellexplanatory essaySickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
In this essay, the author
- Explains that sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow.
- Explains that sickle cell disease is passed down from the parent to the child genetically.
- Explains that a child can have sickle cell trait or swine cell disease. the patient can develop symptoms if they undergo stress, infection, exhaustion, or hypoxia with mild anemia.
- Explains that sickle cell disease occurs when the hemoglobin molecule loses its ability to attach oxygen to itself and changes the healthy red blood cells into a crescent shape.
- Explains that newborns undergo a blood, hearing, and heart screening to check for any chances of inheriting sickle cell disease. if detected early, infections can be prevented and increase survival chances.
- Explains that treatment for sickle cell disease assists to relieve pain and provides additional protection by reducing complications and preventing infections. patients with this ailment strive to get in touch with doctors that are specialized in blood disorders.
- Explains how narcotics are used to treat mild to severe pain, and how droxia reduces the rate of recurrence of pain and acute chest-syndrome.
- Explains that sickle cell disease can be very painful and discomforting for those who suffer with the symptoms that it brings interrupting the lives of patients. even though it has no cure, it can still be managed.
- Explains that sickle cell disease and your baby. march of dimes, mar. 2013. web. 20 feb. 2014. simmon, harvey.
703 wordsRead More - Sickle Cell Diseaseexplanatory essayAccording to the U.S. National Library of Medicine it states that sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
In this essay, the author
- Explains that sickle cell disease is a type of disease where the cells in the human body are sick.
- States that sickle cell disease affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body.
- Explains that sickle cell disease is caused by the sickling of red blood cells, which breaks down prematurely, leading to anemia.
- Explains that anemia can cause shortness of breath, fatigue, delayed growth and development in children, and yellowing of the eyes and skin, which are signs of jaundice.
- Explains that sickle cell disease is most common in africans and african-americans, but also in other ethnic and racial groups, including people from south and central america, the caribbean, mediterranean countries, and india.
- Explains that patients with sickle cell disease may develop severe pain in the chest, back, arms, legs, and abdomen.
- Explains that sickle cell disease is diagnosed by a blood test called hemoglobin electrophoresis, which measures the amount of the abnormally shaped red blood cells.
- Explains that transfusions of red blood cells are given for severe anemia, to prevent strokes, and before surgery.
- Opines that having sickle cell disease isn't the best feeling in the world, but after researching and knowing someone with the disease gave them knowledge on how it is to have it.
- Explains that hydroxyurea is the only fda-approved medication that prevents painful episodes in sickle cell disease.
- Explains that stem cell transplant is the only curative treatment for sickle cell disease. more than 200 patients have undergone stem cells from a matched sibling donor.
- Explains that stem cell transplant is performed in young patients with severe sickle cell disease who have a matched sibling donor.
- Explains that scientists are making progress in the development of new medications that prevent sickling of red blood cells and improve blood flow and delivery of oxygen to the body.
922 wordsRead More - The Sickle Cell Disease (SCD)explanatory essaySickle cell disease has lifelong effects on the body that causes continuous pain and health burdens. “Sickle cell disease (SCD) is a group of disorders affecting the haemoglobin protein leading to red blood cell sickling” (Ngo, 244). The disease can not be contracted from one person to another by airborne or direct contact. Sickle cell disease is inherited from both parents that carry the actual disease. If one parent has the disease and the other parent has the trait then it is a 50% chance that the child would either have the disease or be a carrier of the gene trait. “People with the disease are born with it and can experience complications of anaemia and organ damage to any part of the body starting in infancy” (Ngo, 244). Pain, anemia,
In this essay, the author
- Explains that sickle cell disease is a group of disorders affecting the haemoglobin protein leading to red blood cell sickling.
- Explains that pain is one of the major effects of sickle cell disease and it can vary from mild to severe. working out, overheating, getting too cold, not drinking enough fluids, and getting sick are some triggers.
- Explains that the most common effect of sickle cell disease is anemia, which means the body doesn't have enough red blood cells in its blood.
- Explains that organ damage occurs as a result of sickle cell crisis. lack of oxygen can cause acute to severe damage in the organs.
- Explains that sickle cell disease is a lifelong burden and causes continuous pain and health issues within the body.
790 wordsRead More - George Washingtonexplanatory essayThe gene for hemogoblin-S (which causes the disease) is the most common inherited blood condition in America; although most people only inherit one copy of the gene for HbS, while the other gene, hemogoblin-A, is normal, and can override HbS, blocking the disease. These people have the HbS trait, but not the disease, therefore leading a normal life. For an offspring to acquire the disease, both parents must have the HbS gene, yet the child only has a 25% chance of having Sickle Cells. You cannot catch the disease, you are born with it and it is present for life. There are many complications and harmful effects as the result of the Sickle Cell Disease. The disease causes hemoglobin in the red blood cells, when it does not receive sufficient oxygen, to form into long, sickle shapes with a sticky, chemical surface. When blood cells are this form, they cannot go through the capillaries, blocking off both blood and oxygen. Fortunately only 20% of all red blood cells become Sickle Cells; the sickle cells have a shorter life span; and most blood cells go through the capillaries before becoming sickle-shaped. The most painful effect known from Sickle Cell Disease are episodes of pain called Sickle Cell Crisis, where the body is in need of oxygen, either from physical activities or a sickle blood cell blocking blood passages that lead to organs.
In this essay, the author
- Explains that the sickle cell disease is an inherited blood condition that causes hemoglobin in the red blood cells to form into long, sickle-shaped, sticky, chemical-covered cells.
- Explains that sickle cell disease is a state of suffering, yet it is not as serious as it used to be.
548 wordsRead More - Funding of sickle cell diseases because of Race.analytical essay“In the United States, it's estimated that sickle cell anemia affects 70,000–100,000 people, mainly African Americans” (NHLBI, NIH, Who is at risk for sickle cell anemia). SCD is a disease that is a serious disorder in which the body can make normal blood cells and sickle shape cells. Sickle shape cells can block the blood flow in your vessels and cause pain or organ damage also put you in risk for infections. SCD has no cure available but there are many treatments out there to deal with the complications of it. From over years treatments did get better from way back in the day doctors have learned. Sickle cell disease has lack of attention and funding because it’s only affecting African American the most.
In this essay, the author
- Explains that sickle cell anemia affects 70,000–100,000 people, mainly african americans. scd has no cure available but there are many treatments to deal with the complications of it.
- Explains that sickle cell is a negro inherited disease, which is incorrect not only for african americans, but also for other races.
- Explains that the first funding for sickle cell disease began thirty years ago when federal legislation dealing with the disease was accepted. the gap in funding with researchers and clinical care scd receive less public and professional compared with other prevalent diseases.
- Opines that philanthropy wants to stop the issue of it being about race and income and more on the need of measurements of needs when scd is fighting a prevalent disease.
- Explains that african american communities became apprehensive with misrepresentations when legislation labeled sickle cell as "communicable" disease.
- Analyzes how sca, cystic fibrosis, muscular dystrophy, and phenylketonuria were inherited by african-americans in 1967.
789 wordsRead More