However, in sickle cell disease the red cells become rigid and sticky. They are shaped like sickles or crescent moons. Because these cells are irregular, they can get stuck in small blood vessels. The small blood vessels slow or block blood flow. Without enough red blood cells in circulation a person's body cannot get the adequate amounts of oxygen needed to feel energized.
Abstract Sickle Cell Anemia is a hereditary disease that changes the smallest and most important components of the body. A gene causes the bone marrow in the body to make sickled shapes, when this happens; it causes the red blood cell to die faster. This is what causes Hemolytic Anemia. Older children and adults with sickle cell disease may experience a few complications, or have a pattern of ongoing problems that shorten their lives. The most common and serious complications of sickle cell disease are anemia, pain, fatigue, and organ failure.
The sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell have red blood cells that have mostly hemoglobin's, Sometimes these red blood cells become sickle-shaped or crescent shaped and have trouble going through small blood vessels. When sickle-shaped cells block small blood vessels, less blood can get to that part of the body. Tissue that does not get a normal blood flow eventually becomes damaged.This is what causes the problems of sickle cell disease.As to this day there is really no cure for sickle cell disease.Red blood cells take oxygen from the air we breathe into our lungs to all parts of the body. Oxygen is carried in red blood cells by a substance called hemoglobin(Hemoglobin – is the main substance of the red blood cell.
Every day the body produces new red blood cells to replace old ones, but sickle cells become destroyed so fast that the body cannot keep up. The red blood cell count drops, which results in anemia. This gives sickle cell disease its more common name, sickle cell anemia. The only true way to determine if a person has sickle cell anemia is through a blood test, and if a person does have sickle cell anemia there are ways to help avoid crisis and the pain associated with the disease. There are medicines that help to prevent attacks.
In turn, this could cause organ damage to the body. Sickle cells are also fragile and die very easily due to the fact sickle cells have a lifespan of twenty days instead of the normal one hundred and twenty days for normal red blood cells.This causes the body to have a lower blood cell count, hence the name anemia in sickle cell anemia. Hemoglobin SS happens because of a mutation in chromosome 11. Chromosome 11 contains the gene of hemoglobin-Beta. Hemoglobin (HBB) transports oxygen to your body parts like your lungs.
Sickle-cell anemia is an illness in which the shape of red blood cells is altered to a sickle-like shape (Peachley, n.d.). It is basically the sickling of erythrocytes. The protein molecule, hemoglobin, is the reason for this altered shape. Hemoglobin is found on red blood cells and it is used to provide oxygen to tissues (Peachley, n.d.). In sickle-cell anemia the altered shape of the red blood cells prevent them from passing through blood vessels and this will result in an inadequate amount of oxygen being delivered to tissues in the body (Peachley, n.d.).
Hemoglobin, an iron-rich protein is a component of the red bloods cell which enable it perform its’ functions effectively (NIH, 2013). What are Thalassemias? Thalassemias are a group of blood disorders children inherit from their parents through genes. The body of a person with thalassemia will produce fewer red blood cells that are healthy with less hemoglobin than that of a person without this condition (National Heart, Lung, and Blood Institute, 2013). When a person’s body produces red blood cell below normal, or less hemoglobin, a condition called anemia develops.
Sickle Cell Anemia and Red Blood Cell Physiology Introduction Sickle cell anemia is a disorder in which the body makes crescent-shaped red blood cells. Normal red blood cells are disc-shaped. They move easily through your blood vessels and contain an iron rich protein called hemoglobin. This protein carries oxygen from the lungs to the rest of the body. Sickle cells contain abnormal hemoglobin due to a mutation in the hemoglobin chain.
They block the blood vessels creating obstruction in the regular blood flow. As a result the healthy RBCs cannot pass through the blocked pathway and transport necessary oxygen to the limbs and organs. ‘Thalassemia,’ on the other hand, is a disorder caused by the weakening and destruction of the red blood cells. People with thalassemia make less hemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anemia. Thalassemia occurs when there is a defect in the produc... ... middle of paper ... ... particularly associated with people of Mediterranean origin, Arabs (especially Palestinians and people of Palestinian descent), and Asians.
Their findings were that the patient had the following symptoms: numbness in the fingers, hands, and forearms, the gastric mucosa was atrophic, and high levels of red bloods cells containing nuclei were found in the bone marrow. Further studies found that the blood of a patient with this type of anemia had abnormally large red blood cells with low haemoglobin levels. Doctors during the 20th century knew that patients were anemic but common cures for anemia did not work. This was until the 1920’s when two physicians, George Minot and William Murphy,... ... middle of paper ... ...heir health. Although PA is relatively easy to treat, signs and symptoms can go unnoticed and this disease can be fatal.