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Sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
Unfortunately this disease is passed down from the parent to the child genetically. “If both parents have sickle cell trait (each have one normal hemoglobin gene and one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait (one normal gene, one sickle cell gene), 25% chance of inheriting sickle cell disease (two sickle cell genes), and 25% chance of not inheriting either the trait or the disease (two normal genes) (Harvey)”.
The child can obtain either the sickle cell trait or have a sickle cell disease. The sickle cell trait carries the abnormal gene of the person but they have normal hemoglobin without any symptoms. The patient can start developing symptoms related to the disease if they undergo any stress, infection, exhaustion, or hypoxia with mild anemia. Sickle cell disease occurs when normal hemoglobin has been replaced with sick...
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...minophen (NIH).” Additionally, Hydroxyurea (Droxia) is prescribed that diminishes the rate of recurrence of pain and acute chest-syndrome in patients.
Sickle cell disease can be very discomforting and painful for those who suffer with the symptoms that it brings interrupting the lives of patients. Even though sickle cell disease has no cure it can still be managed to where the patient can live a comfortable life.
Works Cited
"Sickle Cell Disease and Your Baby." Sickle Cell Disease and Your Baby. March of Dimes, Mar. 2013. Web. 20 Feb. 2014.
Simmon, Harvey. "Sickle Cell Disease." University of Maryland Medical Center. N.p., 14 Mar. 2013. Web. 06 Feb. 2014.
"Sickle Cell Research: Symptoms, Diagnosis, Treatment and Recent Developments | NIH MedlinePlus the Magazine." U.S National Library of Medicine. U.S. National Library of Medicine, 2011. Web. 06 Mar. 2014.
Sickle cell disease is a group of disorders that affects the blood, specifically, a molecule called hemoglobin in red blood cells (“sickle cell disease”, 2016). Hemoglobin is a molecule that facilitates the delivery of oxygen throughout the body (“sickle cell disease”, 2016). A mutant form of the hemoglobin molecule causes red blood cells to become crescent shaped or “sickled shaped” (Lonergan et. al. 2001). This distorted shape of red blood cells causes rigidity of the blood cells and vaso-occulusion (or the blood vessels to become clogged) (Rees et.al., 2010). This often leads to a low number of red blood cells (anemia), repeated infections and episodes of pain that are periodic (“Sickle cell disease”, 2016). Although sickle cell disease
What is Sickle cell disease? Sickle cell affects a disease; that disease is called which affects the hemoglobin when the red blood cells that send oxygen through the body are killed off and weakened. Sickle cells can be found in every 1 and 1000 African Americans, it is affecting about 70,000 to 80,000 Americans in the United States. Sickle cell is a death threatening disease, and the severity of symptoms can vary from person to person (Sickle cell disease (SCD), 2015). Some people have light conditions, but others can have severe conditions, which, mean they could be hospitalized. Characteristics of this disease are caused by a minimum of low blood cells, which is called anemia.
Sickle Cell Disease (SCD) (also known as Sickle Cell Disorder or Sickle Cell Anemia) is an inherited blood disorder where the red blood cells have abnormal sickle-shaped hemoglobin S (HbS) called sickle haemoglobin (National Heart Lungs and Blood Institute (NHLBI), 2015). The disease, according to medical sciences, is inherited from both parents as part of their genetic makeup and is usually caused by some abnormalities in haemoglobin which is a protein in red blood cells that conveys oxygen through the body. Whereas normal red blood cells are round, in people with sickle cell anemia, a defective substance in red blood cells changes the shape of the cells. The normal haemoglobin called haemoglobin A (HbA) is replaced by HbS which later becomes
The name of this patient is Davon; he is a five-year-old African-American male whom just moved from Chicago. The patient was visiting his pediatrician for a physical to enter kindergarten. The patient mother gave her history about confirming that she has the sickle cell trait and would like to know if her son is also a carrier for sickle cell. ("Sickle Cell Disease", 2015) “Sickle cell trait inherited from both hemoglobin A and S, in the red blood cells”. Those with this disease are still capable of having a healthy life. For instance, if one parent has sickle cell trait, and the other parent does not will only lead to the child having sickle cell trait or nothing. If both parents have the trait, then the child will genetically develop sickle cell disease inside the mother’s womb. Sickle cell trait is a transmitted disease that travels through the red blood cells. The symptoms of sickle cell trait is that when the skin gets pale, always cold, or even tired then that is a sign of having this disease. The patient cannot prevent this disease, due to this is something that is passed on from the womb and birth. Daily doses of penicillin can control the infection; on the other hand, it is not preventable. The only way to make sure that it does not get worse is the person must eat foods with high iron and even
Sickle cell disease is autosomal recessive; that is, both parents must have at least one copy of the gene before there is a risk of producing children with the disease (homozygotes). When both parents are carriers, the risk of bearing such a child is 25 percent with each pregnancy. Carriers themselves are almost symptomless and may have no idea of their status unless they are screened.
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
Sickle cell anemia is a genetic disorder. For a person to have sickle cell anemia they must have received two copies of the gene, one from each parent. A person with the sickle cell trait only received one sickle cell gene and a normal hemoglobin gene. People who have the sickle cell trait do not develop sickle cell anemia however they can pass the deformed gene on to their children. People with just the trait do not face the complications caused by the disorder.
Sickle Cell is a disease that affects many people in the world today. It is the number one genetic disorder in the United States. Sickle Cell is deficient hemoglobin. Hemoglobin is what functions in providing oxygen to the cells in the body. The sickle shape comes from the atypical hemoglobin s molecules. Hemoglobin molecules are composed of two different parts called the alpha and beta. The beta subunit of the hemoglobin molecule has a mutation in gene, on chromosome 11 which produces the change in the red blood cell shape causing them to die and not reproduce accurately. The change in shape causes the red blood cells to get stuck in the blood vessels and block the effectiveness of oxygen transport causing pain and organ damage to the body. This disease does not have a cure and some common treatments are used to help patients live with the disease. Some treatment options are antibiotics (penicillin) to prevent infections, blood transfusions, folic acid that help produces new blood cells. These are just some of the current treatments for Sickle Cell.
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell anemia is a disease that has to be inherited from both parents. Both parents have sickle cell trait, which means each parent has sickle hemoglobin and normal hemoglobin. So people with the sickle cell trait can pass the sickle cell gene to their children. Most families that come from Africa, South Central, and Central America are more common with sickle cell anemia. According to National Heart, Lung and Blood, it’s estimated that the sickle cell disease has affected 70,000-100,000 people mainly African Americans (National Institute of Health, 2012). Hispanic Americans also are common to having sickle cell anemia. According to National heart, Lung, and Blood Institute, statistics shows sickle cell anemia occurs in about 1 out of every 500 African American births and 1 out of 36,000 Hispanic American births (National Institute of Health, 2012). Signs of sickle cell anemia don’t show until after 4 months of age. Sickle cell anemia begins from ...
Sickle cell anemia hurts many people today in fact it hurts about 72,000 Americans. But some doctors are finding cures for this inherited disease. This disease causes mainly strokes and fever. With this disease a stroke is not predictable, a stroke can happen as early as a one month old as a baby. It can hurt a person really bad because it causes them to not be able to do many things like can't play sports, and things that gets your heart pumping because if the red blood cells gets clogged up it can causes a stroke because oxygen can't flow. Most Americans who have sickle cell anemia are of African descent. The disease also affects Americans from the Caribbean, Central America, and parts of South America, Turkey, Greece, Italy, the Middle East and East India. Since sickle cell anemia is an inherited disease if both parents have the trait for sickle cell, their baby's chances of having sickle cell disease is one in four.
Sickle Cell Disease is a condition where there is not enough healthy red blood cells to carry oxygen throughout the body. Another name for sickle cell disease is sickle cell anemia. Sickle cell anemia is inherited as a simple recessive condition. In normal red blood cells, the cells are usually flexible and round. However, in sickle cell disease the red cells become rigid and sticky. They are shaped like sickles or crescent moons. Because these cells are irregular, they can get stuck in small blood vessels. The small blood vessels slow or block blood flow. Without enough red blood cells in circulation a person's body cannot get the adequate amounts of oxygen needed to feel energized.
Sickle Cell Anemia is an inherited disease that targets the red blood cell. It is a lifelong disease and the severity of it varies from person to person. This disease turns regular healthy red blood cells into abnormal sickle shaped blood cells People with Sickle cell Anemia have hemoglobin in the red blood cells that is abnormal, which causes a person to have Hemoglobin S.
Like many disorders, sickle cell disease is inherited. A person who has the disorder must inherit the two genes for sickle hemoglobin from one’s parents. Many people could be carriers for the disease,possess no symptoms, and later pass it on to their own children. Furthermore, when you were conceived, you received a set of genes from your dad(sperm) and another set from your mom(egg). Inside structures, called chromosomes, where DNA is tightly coiled, there contained are
Sickle cell disease is the most common inherited disorder in the United States, affecting 70-80,000 Americans. Occurrence is 1 in 1,000 to 1,400 Hispanic Americans and 1 in 500 African Americans (Genetics Home Reference,