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Pathophysiology of parkinson disease essay
Quizlet parkinson's disease
Quizlet parkinson's disease
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Parkinson’s Disease is known as one of the most common progressive and chronic neurodegenerative disorders. It belongs to a group of conditions known as movement disorders. Parkinson disease is a component of hypokinetic disorder because it causes a decreased in bodily movement. It affects people who are usually over the age of 50. It can impair an individual motor as well as non-motor function. Some of the primary symptoms of Parkinson’s disease are characterized by tremors or trembling in hands, legs and arms. In early symptoms the tremor can be unilateral, appearing in one side of body but progression in the disease can cause it to spread to both sides; rigidity or a resistant to movement affects most people with Parkinson’s disease, causes muscles to be tensed and contracted so that the person feel stiff. Bradykinesia is slowness in movement; person has difficulty performing routine work such as dressing, eating and walking, and it makes easy tasks somewhat difficult. Difficulty with walking and balancing is another common symptom of Parkinson’s Disease; it causes an individual to fall very easily. Some of the non-motor symptoms include disturbances in cognition, emotions (mood and motivation), sensation and perception, olfactory system, behavior inhibition, sleep disruption, autonomic function, decrease in gastric stability and fatigue (Cronin-Golomb, 2013). As these symptoms become progressive patients can have difficulty walking, talking or completing other daily task. Most of the time symptoms begin on one side of the body but as the disease progresses; it can affect both sides of the body.
There are many causes of Parkinson’s disease but the primary and major cause is when there is the death or break down of cells in the...
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...n-motor function. Parkinson’s disease contains symptoms such as tremor, rigidity, bradykinesia and difficulty maintaining balance and few other non-motor symptoms such as cognition and autonomic etc. The main cause of Parkinson’s is the reduction of Dopamine in part of basal ganglia called Subtantia Nigra; there are varies other reason which researchers has found to be the cause of Parkinson’s disease. There are no profound blood/lab tests that can be used to diagnose Parkinson’s disease but several physical and neurological tests can be used to diagnose for Parkinson’s disease. Parkinson’s disease is a complex disease, so there is no cure for it yet but different treatments with drugs and therapies can help to reduce/improve the symptoms produce by Parkinson’s disease. Researchers are working really hard and hope to find the cure for Parkinson’s disease in future.
What exactly is Parkinson’s disease? It is a disease of the nervous system; it falls into a group of conditions called motor system disorders. The initial symptoms are normally tremors of a limb, especially when the body is resting. Bradykinesia, akinesia, and postural inability are also symptoms that occur. These symptoms will worsen over time (Genetics Home Reference).
Hypokinetic Dysarthria is a motor speech disorder that is often associated with Parkinson’s disease (PD). It can occur when there is interference in the basal ganglia control circuit. These disruptions can include “degenerative, vascular, traumatic, infectious, inflammatory, neoplastic, and toxic-metabolic diseases (Duffy, 2013, p. 176).” Damage to the basal ganglia control circuit results in reduced range of motion as well as the inability to inhibit involuntary movements. Hypokinetic dysarthria is most commonly caused by PD; a progressive, neurogenic disease that is characterized by tremor, rigidity, slowness of movement, and incoordination. Eighty-seven percent of hypokinetic dysarthria cases are associated with degenerative disease (Duffy, 2013).
People who have been diagnosed with this lifelong disease have either started to see the early signs and symptoms or have yet to recognize them. The negative impact that fatigue, loss of muscle strength and in-coordination has on the patients with Parkinson’s disease can be improved with a well-balanced exercise regimen. The three most common physical symptoms the patient will experience are tremors, rigidity, and bradykinesia. “Tremors while at rest are the most common initial symptom and are present in around 70 percent of cases at disease onset. It often presents as a pill rolli...
Parkinson's Disease is a mysterious disease that affects the central nervous system and can be very difficult to treat and live with. It is classified as a motor system disorder but is a progressive, chronic disease resulting in
The four key symptoms of Parkinson’s disease are tremors of the hands, arms, legs, or
Parkinson disease (PD), also referred to as Parkinson’s disease and paralysis agitans, is a progressive neurodegenerative disease that is the third most common neurologic disorder of older adults. It is a debilitating disease affecting motor ability and is characterized by four cardinal symptoms: tremor rigidity, bradykinesia or kinesis (slow movement/no movement), and postural instability. Most people have primary, or idiopathic, disease. A few patients have secondary parkinsonian symptoms from conditions such as brain tumors and certain anti-psychotic drugs.
Parkinson's is an idiopathic, multifactorial neurodegenerative disease that attacks neurotransmitters in the brain called dopamine. Dopamine is concentrated in a specific area of the brain called the substantia nigra. The neurotransmitter dopamine is a chemical that regulates muscle movement and emotion. Dopamine is responsible for relaying messages between the substantia nigra and other parts of the brain to control body movement. The death of these neurotransmitters affects the central nervous system. The most common symptoms are movement related, including shaking, rigidity, slowness of movement and difficulty with posture. Behavioral problems may arise as the disease progresses. Due to the loss of dopamine, Parkinson's patients will often experience depression and some compulsive behavior. In advanced stages of the disease dementia will sometimes occur. The implications of the disease on the anatomy and physiology of the respiratory and phonatory systems significantly control speech.
Parkinson’s disease is a chronic, progressive neurodegenerative disorder characterised by resting tremor, slowed movements, rigidity and postural instability (Casey G, 2013). It is the second most common neurodegenerative disorder after Alzheimer’s (Martin and Mills, 2012). There is a great variability in reported incidence rates, probably due to difference in diagnostic criteria and case ascertainment, with reported rates in Australia and in Western countries ranging from 8.6 to 19.0 per 100,000 population (J Macphee and D Stewart, 2012). The two main brain structures affected by Parkinson’s are the substantia nigra pars compacta, which is located in the midbrain and other parts of the basal ganglia, w...
Thomas, C. G. (2013, November 25). National Institute of Neurological Disorders and Stroke. Gene-silencing study finds new targets for Parkinson's disease, pp. 1-2. Retrieved December 13, 2013, from http://www.nih.gov/news/health/nov2013/ninds-24.htm
The fact that early signs of Parkinsonism can easily be overlooked as normal aging, further complicates diagnosis. Therefore, primary care physicians of the middle-aged and elderly population must be extremely sensitive to patients’ outward appearance and changes in movement ability. Most signs and symptoms of Parkinson disease correspond to one of three motor deficiencies: bradykinesia, akinesia, tremor, and rigidity. The first two qualities are usually present before tremor, but often attributed to aging by the patient and even the physician, and thus the disease is rarely diagnosed until tremor becomes evident much later. An average of 80% of the nigrostriatal neurons may have already degenerated by the time Parkinsonism is diagnosed, which complicates treatment (Fitzgerald, 130).
Parkinsons disease Learning is defined as, a change in the capability of a person to perform a skill that must be inferred from a relatively permanent improvement in performance as a result of practice of experience (Magill 247). For healthy people to learn a skill, they must show improvement, consistency, stability, persistence, and adaptability. However, for patients with Parkinsons Disease, it is not as simple. Bradykinesia, the slowed ability to initiate and continue movements, is a well-recognized side effect of Parkinsons Disease. In Rostami and Ashayeris study, Effects of motor skill practice on reaction time and learning retention in Parkinsons Disease, they investigated whether or not short-term practice could improve Bradykinesia. Patients with Parkinsons Disease frequently spend more time not only initiating voluntary movements, but also more time carrying out the voluntary movements. Thus, the study gathered 9 patients (7 males and 2 females) with Parkinsons Disease and 9 controls (7 males and 2 females) that were healthy and disease free. The participants were instructed to look at their monitor and to carry out a hand-to-mouth reach when prompted by the random stimulus on the monitor. The researchers used the Kinemetrix 3D Motion Analysis System and three markers that were positioned on the lateral aspect of the wrist, elbow, and shoulder joints to record and analyze the movements in three-dimensional space. Though all of the participants were right-handed, they were all instructed to use their left hand to complete the task because in all of the participants the left arm appeared to be more bradykinetic. The purpose of this study was to see if reaction time coul...
The first scientist who discovered Parkinson Disease (PD) was an English doctor, James Parkinson. In 1847 Dr Parkinson published a paper entitled "Essay on Shaky Palsy" describing six
Without this vital dopamine nerve cells cannot properly transmit messages resulting in a loss of muscle function.Parkinson's Disease is a non-communicable disease and doctors have not yet found out whether or not it is a hereditary disease. Parkinson's Disease has many distinct symptoms. The symptoms are:Muscle Rigiditystiffness difficulty bending arms or legsunstable, stooped, or slumped-over posture loss of balancewalking pattern changesslow movements difficulty beginning to walk difficulty initiating any...
Parkinson’s disease – Affecting the central nervous system, Parkinson’s affects basic movement, leading to tremors. Typically characterised by shaking hands.
Many people around the world today suffer from Parkinson’s disease and other movement disorders. A movement disorder is a disorder impairing the speed, fluency, quality, and ease of movement. There are many types of movement disorders such as impaired fluency and speed of movement (dyskinesia), excessive movements (hyperkinesia), and slurred movements (hypokinesia). Some types of movement disorders are ataxia, a lack of coordination, Huntington's disease, multiple system atrophies, myoclonus, brief, rapid outbursts of movement, progressive supranuclear palsy, restless legs syndrome, reflex sympathetic dystrophy, tics, Tourette's syndrome, tremor, Wilson disease, dystonia, which causes involuntary body movement, and Parkinson's disease. Parkinson’s disease, Tourette’s syndrome, and tics are one of the most widely known of these disorders, known to impair people of movements and rob them of their lives.