Despite the aforementioned psychological mechanisms associated with pain perception, it is important to mention that pain is first and foremost a biological sensation processed initially by a response in the nerve endings attached to the tissue in the affected area of tissue damage (Moseley, 2017). It is important to identify that there are multiple processes involved in the biological definition of pain, different types of pain are more complex than others and two types of pain are never chemically processed the same way. Stimuli is processed in three ways: Transduction, transmission and perception. Transduction is the process of stimulus being converted into “receptor membrane depolarisation and nerve impulses” (Fields, 2013) this occurs in the ‘primary afferents’ (Pas) these PAs …show more content…
Due to the nature of the Transmission process there are many different chemical factors that can affect the transfer of nerve signals to the nociceptors, this can include drug intervention. Analgesics or painkillers generally fall into three main medicine groups, Paracetamol, Non-steroidal Anti-inflammatory Drugs (NSAIDS) or Opioids, all three painkillers can be taken selectively together as they all treat pain differently (Whitehall, 2015). Opioids work by attaching to opioid receptors in the brain and spinal cord inhibiting pain sensed in these parts of the body therefore reducing the pain felt (Freynhagen, Geisslinger & Schug, 2013), opioids generally come in two varieties weak opioids such as codeine and dihydrocodeine and strong opioids like morphine, oxycodone, and pethidine, these tend to be used in more severe cases of pain such as post-operative pain medication. There is evidence that suggests that opioids can increase pain tolerance though some have suggested that the increased positive effects perceived while
It has been shown that intrathecal administriton of GABA receptor antagonists cause hyperalgesia and allodynia. Constitutive, the increase in the endogenous GABA activity in the spinal cord alleviate pain resulting from noxious and innoxious mechanical and thermal stimuli. Different GABA receptors have different roles in alleviating thermal and mechanical pain in different animal pain models. There is no study to date that has examined the involvement of GABA A and GABA B in sensory dimension of neuropathic pain resulting from compression of spinal cord. The current study tests the hypothesis that GABA A or GABA B receptors contributes to the allodynia and hyperalgesia observed after spinal cord injury. The results showed that the effect of GABA A and GABA B receptors on mechanical hyperalgesia is similar but these receptors have different effects on thermal hyperalgesia. While using baclofen as GABA B receptor agonist does not affect the thermal pain, thermal hyperalgesia resulting from spinal cord injury was greatly alleviated by different doses of GABA A agonist, muscimol. Both Baclofen and muscimol are able to reduce the mechanical and cold allodynia has been seen after spinal cord injury but the effect of baclofen is dose dependent with no effect in higher doses used in this study. While almost all doses of muscimol were used in this study reduce the amount of cold and mechanical allodynia. The other result obtained in this study is the short term effect of GABA agonist. The anitinociceptive effect of Baclofen and muscimol appear to be maxium at 15 min after injection and gradually diminished by time and their analgesic effect disappeared 3 hours after injection.
The most common and well described pain transmission is “gate control theory of pain”. This theory was first proposed by Melzack and Wall in 1965 whereby they used the analogy of gate to explain the inhibition of pain which exists within the dorsal horn of the spinal cord. For instance, when tissue damage occurs, substances such as prostaglandin, serotonin, histamine and bradykinin are released from the injured cell. Individual usually consume or apply pain medications such as NSAIDs whereby these medications will cause electrical nerve impulse at the end of the sensory nerve fiber via nociceptor. Nociceptor is a pain receptor that is commonly found in the skin, cornea of eye and organ of motion such as muscles and ligaments. These nerve impulses
What exactly is pain? According to Webster's dictionary, pain is "physical suffering typically from injury or illness; a distressing sensation in a part of the body; severe mental or emotional distress". Most everyone reading this paper has experienced some form of physical pain at some point during their lives; most everyone has even experienced the common daily pains such as stubbing our toe as we walk through the living room, accidentally biting our tongue as we chew, and having the afternoon headache after a long day of work. No matter the fact that it is unpleasant, pain has a very important role in telling the body that something is not right and leading to behavior that will remove the body from a source of potential injury. Imagine if we could not experience pain. We would not be able to change our behavior in any way when touching the burning hot dish in the oven, resulting in potentially serious burns. We could not recognize that perhaps we twisted an ankle when walking down the stairs, thus continued walking on that foot would exacerbate the injury to the point of not being able to walk at all. Indeed, pain is not pleasant, but in many cases it is an important way for our nervous system to learn from and react to the environment.
Pain has been defined by Coates & Hindle as an unpleasant emotional and sensory experience which signals a potential or actual damage to tissues (2011, p. 213). Pain is a common human experience and can emanate from injury and illness. There are two main types of pain; acute pain is short-lived, lasting for minutes or several days and its onset often takes place rapidly. It results from the activation of pain nerve endings or nociceptors either by internal or external pain stimuli. On the other hand chronic pain is continuous and sometimes recurrent and can last for weeks, months or even years. Chronic pain is usually not located at or related to the tissue undergoing trauma (Draper & Knight, 2007, p. 104). Various theories have been proposed to explain the mechanism underlying the transmission and perception of pain.
According to CDC in the year 2015 opioids played a part in 33,091 deaths. Now you may ask what an opioid is. An Opioid is a compound that binds to opioid receptors in the body to reduce the amount of pain. There are four main categories of opioids, one being natural opioid analgesics including morphine and codeine, and semi synthetic opioid analgesics, including oxycodone, hydrocodone, hydromorphone, and oxymorphone. The second category being methadone, a synthetic opioid, the third category being synthetic opioid analgesics other than methadone includes tramadol and fentanyl. The last category is an illicit opioid that is synthesized from morphine called heroin.
Opiates are a class of drugs that are used for chronic pain. Opioids are substances that are used to relieve pain by binding opiate receptors throughout the body, and in the brain. These areas in the brain control pain and also emotions, producing a feeling of excitement or happiness. As the brain gets used to these feelings, and the body builds a tolerance to the opioids, there is a need for more opioids and then the possibility of addiction. There are different forms of opioids manufactured such as Morphine, Oxycodone, Buprenorphine, Hydrocodone, and Methadone.
These patterns occur only with intense stimulation. Because strong and mild stimuli of the same sense modality produce different patterns of neural activity, being hit hard feels painful, but being caressed does not. It suggested that all cutaneous qualities are produced by spatial and temporal patterns of nerve impulses rather than by separate, modality specific transmission routes. Gate control theory of pain states that stimulation by non-noxious input is able to nullify pain.
Conclusions. An adequate and clear understanding of the concept of pain and implementing interventions of pain treatment and management is essential in the clinical settings. Understanding the concept of pain is necessary for its relationships with other concepts that are related and similar to the pain experience for theory building. The in the end, understanding the concept of pain will ultimately benefit the patient and lead to better and approp...
This type of pain is classified as nociceptive pain or the normal pain process. It involves four processes that occur continuously: transduction, transmission, perception, and modulation. Neuropathic pain is not as easily understood because it involves damage and dysfunction of nerve cells in the peripheral nervous system (PNS) and/or the central nervous system (CNS) (Ignatavicius & Workman, 2016). Most patients describe neuropathic type pain as burning, stabbing, shooting, and/or a feeling pins and needles (Ignatavicius & Workman, 2016). This type of pain is hard to treat because of the subjective nature of pain and not all the causes of neuropathic pain are understood. This paper is a review of pharmacological and non-pharmacological management of neuropathic pain management. Three articles were found on this subject and summarized to inform its readers on recent research conducted within the last five years. The first article reviewed was a research study to determine strategies patient’s implemented in order to cope with
There are different types of pain which may be suffered by an individual with cancer, with some patients suffering only one type of pain, but others experiencing a range of all three types. Identifying the type of pain suffered is the first major step in ensuring effective treatment, as not all respond to different treatments in the same way (De Conno & Caraceni, 1996, p.9).
Phantom pain refers to the phenomenal experience of pain in a body part that has been amputated or deafferented (Flor, Nikolajsen & Jensen, 2006). The characteristics of phantom pain have been described to occur in quick and sudden attacks of pain shooting up and down the amputated limb as well as cases of constant, excruciating pain whilst intensely perceiving the amputated limb to be cramped or postured abnormally (Katz, 1992). Approximately eighty percent of amputees report suffering from or at least experiencing some level of phantom pain post amputation; therefore it is a prominent issue (Flor, Nikolajsen & Jensen, 2006). Phantom pain is neuropathic pain that has no individual trigger but instead a plethora of psychobiological aspects of neuroplasticity that contribute to the cause of phantom pain (Grusser, Diers & Flor, 2003). The following will: outline the role of the peripheral and central factors associated with phantom pain and discuss the cortical reorganisation of the somatosensory cortex in relation to phantom pain.
The major concepts deduced from the hypothesis fall under three categories: (1) multimodal intervention, (2) attentive care, and (3) patient participation. Multimodal intervention includes the concepts of potent pain medication, pharmacological adjuvants, and non-pharmacological adjuvants. Attentive care relates to the assessment of pain and side effects and intervention along with reassessments. Patient participation includes goal setting and patient education. The resulting outcome of these three categories working together is the balance between analgesia and side effects.
In a pain assessment, the pain is always subjective, in a verbal patient; pain is what the patient says that it is. Nurses must be able to recognize non verbal signs of pain such as elevated pulse, elevated blood pressure, grimacing, rocking, guarding, all of which are signs of pain (Jensen, 2011). A patient’s ethnicity may have a major influence on their meaning of pain and how it is evaluated and responded to behaviorally as well as emotionally (Campbell, & Edwards 2012). A patient may not feel that their pain is acceptable and they do not want to show that they are in pain. For some people, showing pain indicates that they are weak. Other patients will hide their pain as they do not want to be seen as a bother or be seen as a difficult patient.
The way that each individual interprets, retrieves, and responds to the information in the world that surrounds you is known as perception. It is a personal way of creating opinions about others and ourselves in everyday life and being able to recognize it under various conditions. Each person’s perceptions are used as a kind of filter that every piece of information has to pass through before it determines the effect that it has or will have on the person from the stimulus. It is convincing to believe that we create multiple perceptions about different situations and objects each day. Perceptions reflect our opinions in many ways. The quality of a person’s perceptions is very important and can affect the response that is given through different situations. Perception is often deceived as reality. “Through perception, people process information inputs into responses involving feelings and action.” (Schermerhorn, et al.; p. 3). Perception can be influenced by a person’s personality, values, or experiences which, in turn, can play little role in reality. People make sense of the world that they perceive because the visual system makes practical explanations of the information that the eyes pick up.
Trauma relates to a type of damage to the mind that comes from a severely distressing event. A traumatic event relates to an experience or repeating events that overwhelmingly precipitated in weeks, months, or decades as one tries to cope with the current situations that can cause negative consequences. People’s general reaction to these events includes intense fear, helplessness or horror. When children experience trauma, they show disorganized or agitative behavior. In addition, the trigger of traumas includes some of the following, harassment, embarrassment, abandonment, abusive relationships, rejection, co-dependence, and many others. Long-term exposure to these events, homelessness, and mild abuse general psychological