Discussion
It has been shown that intrathecal administriton of GABA receptor antagonists cause hyperalgesia and allodynia. Constitutive, the increase in the endogenous GABA activity in the spinal cord alleviate pain resulting from noxious and innoxious mechanical and thermal stimuli. Different GABA receptors have different roles in alleviating thermal and mechanical pain in different animal pain models. There is no study to date that has examined the involvement of GABA A and GABA B in sensory dimension of neuropathic pain resulting from compression of spinal cord. The current study tests the hypothesis that GABA A or GABA B receptors contributes to the allodynia and hyperalgesia observed after spinal cord injury. The results showed that the effect of GABA A and GABA B receptors on mechanical hyperalgesia is similar but these receptors have different effects on thermal hyperalgesia. While using baclofen as GABA B receptor agonist does not affect the thermal pain, thermal hyperalgesia resulting from spinal cord injury was greatly alleviated by different doses of GABA A agonist, muscimol. Both Baclofen and muscimol are able to reduce the mechanical and cold allodynia has been seen after spinal cord injury but the effect of baclofen is dose dependent with no effect in higher doses used in this study. While almost all doses of muscimol were used in this study reduce the amount of cold and mechanical allodynia. The other result obtained in this study is the short term effect of GABA agonist. The anitinociceptive effect of Baclofen and muscimol appear to be maxium at 15 min after injection and gradually diminished by time and their analgesic effect disappeared 3 hours after injection.
Currently pharmacological mechanisms affect neurop...
... middle of paper ...
...tive to intrathecal administration of morphin than tactil allodynia. Therefore, examination of both modalities is important when examining the spinal pharmacology of the nerve-injured state
Our results provide the first demonstration that GABAA but not GABA B receptor–selective agonists reverse the thermal hyperalgesia produced by spinal cord injury. In parallel, we demonstrate that in spinal cord injury similar to peripheral nerve injury, GABAA and GABAB receptor agonists reduce cold and tactile allodynia and mechanical hyperalgesia. In addition, our studies used a sensitive, reproducible test of motor function to compare the antiallodynic, antihyperalgesic, and motor effects of GABA receptor agonists. The data suggest that GABAA agonists may be efficacious in the treatment of neuropathic pain with thermal hyperalgesia without sensory or motor side effects.
The most common and well described pain transmission is “gate control theory of pain”. This theory was first proposed by Melzack and Wall in 1965 whereby they used the analogy of gate to explain the inhibition of pain which exists within the dorsal horn of the spinal cord. For instance, when tissue damage occurs, substances such as prostaglandin, serotonin, histamine and bradykinin are released from the injured cell. Individual usually consume or apply pain medications such as NSAIDs whereby these medications will cause electrical nerve impulse at the end of the sensory nerve fiber via nociceptor. Nociceptor is a pain receptor that is commonly found in the skin, cornea of eye and organ of motion such as muscles and ligaments. These nerve impulses
Millie refers to Romans 8:28. She says that she believes God does not put anything in our lives that does not have a purpose. She even believes that to be true with her Trichotillomania. Millie decided to search for the reason that God put Trichotillomania into her life. “The Lord showed me that I needed to give trichotillomania to Him. He would then be the One to help get me through my ups and downs. He gave me the strength that I needed to face life and handle my problems” (Mason 2008). Once Millie came to this realization she found that she no longer need Trichotillomania to be her friend in order to lift her moods or help her relax. In fact, she no longer needed the hurtful act at all in her life.
Aoki KR. Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology 2005:26: 785-793.
During the nineteenth century a variety of alternative medical traditions became popular in the United States. There was a shift in how people began to view their physical, mental, and emotional health. A type of alternative medicine that quickly became popular in the United States and Europe was the tradition of hygeiotherapy. This form of treatment included hydropathy a type of water-cure treatment and combined that with exercise, dietary reform, sexual restraint, and any behaviors that were viewed as unhealthy.
As a pain killer, morphine is used in hospitals around the United States for pain management and post-surgery. The main types of consumption is through smoking, snorting, rectal, I.V, orally, and through injection. A pump can also be used to administer the drug to the patient. Most times pumps are used in extreme cases of nerve disorders which usually entail a catheter being microscopically implanted into the spinal cord. The use of a pump is normally for pain management. Pumps are filled with a months or less supply of the drug, which is administered from the abdomen to the spinal area of pain. It basically numbs erratic nerve function and allows a normal life to be had by the patient. Morphine can also be us...
Two treatment types are being studied for spinal cord injury: injection of an antagonist of the ATP-sensitive receptor P2X7 and transplantation of human embryonic stem cell derived oligodendrocyte progenitor cells. In the spinal cord, ATP can act as an excitatory neurotransmitter (Domercq et al,. 2009). ATP is released in excess for six hours after the initial damage. Most tissue damage happens after the main injury occurs, so finding a treatment that will slow the secondary injury down is a main interest for clinical treatment studies. Injecting a P2X7 antagonist that is sensitive to ATP into the region of the spinal cord that has been damaged has been found to slow down secondary injury (Peng et al., 2009). Also, demyelination of neurons can be found after spinal cord injury. Transplanting human embryonic stem cell derived oligodendrocyte progenitor cells into the damaged tissue has shown to help with remyelinating the neurons. Th...
Peripheral and central mechanisms involving nerve lesions and their input are substantial when perceiving phantom pain. Due to the impairment of peripheral nerves in the process of amputation, regenerative sprouting of damaged axons occurs and the activity rate of inflamed C-fibres and demyelinated A-fibres spontaneously increases (Flor, 2002). As a consequence of this nerve injury, a neuroma, which is a mass of pruned and tangled axons, may form in the residual limb producing abnormal (ectopic) activity (Katz, 1992). Flor, Nikolajsen and Jenson (2006) proposed that ectopic discharge from a neuroma in the stump illustrates abnormal afferent input to the spinal cord, which is a possible mechanism for unpro...
Simple musculoskeletal back pain has symptoms of pain in the lumbrasacral area of the back (Jackson & Simpson, 2006). The upper thighs and knees are also known to be affected (Jackson & Simpson, 2006). This pain is usually described as a dull pain (Jackson & Simpson, 2006). Spinal nerve root pain is localised down the leg, and usually continues below the knee and into the feet (Jackson & Simpson, 2006). It has been d...
Roxane Gay, an American feminist writer and author of “My Body is Wildly Undisciplined” writes about a reality television show of people making sacrifices to reduce their body weight. Roxane Gay is successful in persuading her audience due to the evidence and persuasive personal anecdotes. Roxane focuses on “The Biggest Loser” too much in her article. She uses many examples to explain her argument which were “The Biggest Loser” and “Weight Watchers”, and herself. Roxane understands the tension between desire and denial, between self-comfort and self-care. She only talks about the issues that may have a negative effect of these television shows to persuasive her audience to agree with her. For an example, she uses “The Biggest Loser” to confirm her opinion to explain to her audience that harming your body to feel better is not okay at all. There are other suggestions to reduce your body weight, instead of harming your body. Additional, she gives vivid description on how she felt which made a connection between the author and her audience. The summary of the overall text was satisfying because her audience had better understanding on how she
Understanding Sciatica: symptoms & diagnosis. What is a sciatica? Sciatica is the name given to any case of pain that is caused by irritation or compression of the sciatic nerve. The sciatic nerve is the longest nerve in the body, running from the lower back down the back of each leg.
Potent pain medication contains the aspects of utilizing medications such as morphine or demerol, how the medications are dispensed, and t...
Wunderlich, R. P., Peters, E. J., Bosma, J., & Armstrong, D. G. (1998). Pathophysiology and treatment of painful diabetic neuropathy of the lower extremity. Southern Medical Journal, 91, 894-898.
Rationale: Therapeutic use of self by the nurse and concrete task definition and assignment reinforce positive coping strategies and allow caregivers to feel less guilty when tasks are delegated to multiple caregivers. Ackley and Ladwig p. 286
The bridging of native traditions with modern imperial ways has a direct effect on the minds of Zimbabwean girls and women. Dangarembga drew inspiration for her title from the quote “the condition of the nation is a nervous one”, from Frantz Franon’s book Wretched of the Earth. The reader sees this idea of nervousness displayed within the female main characters of this novel. “ Its bad enough, when a country gets colonised but when the people do as well! That’s the end, really, that’s the end. (Nervous Conditions,150). This quote stated by Nyasha addresses how colonialism and imperialism are not just cultural, political and economical, but psychological as well. It infiltrates the minds of the citizens and their very cultural existence. The women in this novel are faced with the choice of embracing the British ways or running back to their Shona roots. No matter the choice they make, the Imperial control of the British Empire over Zimbabwe affects the minds of these women. The title of Dangarembga's novel, Nervous Conditions, alludes to the influence imperialism has on the minds of Tambu, Nyasha and Maiguru as they struggle to re-define themselves in a white man’s world.
that she has a firm sense of her identity and to mix that with a