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Essay on therapies in hemophilia
Essay on therapies in hemophilia
Essay on therapies in hemophilia
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Hemophilia
Severe bleeding. That's what happens when a person has Hemophilia. "More than 25,000 people in the United States have Hemophilia" (Description of Hemophilia 1). "Hemophilia is an inherited deficiency of a blood-clotting factor that results in episodes of dangerous bleeding" (Hemophilia 1). As you read through this essay, you will learn more about the disease. Some characteristics should be. First you will learn about the diagnosis and prognosis of Hemophilia. Second you will learn the causes and incidences of Hemophilia. And finally you will learn about the treatments and ways of life for the people with Hemophilia.
First off, I will tell you about the prognosis and the diagnosis of Hemophilia. "One of the ways to diagnose Hemophilia is to check the family history of the patient. If your family had Hemophilia, then you have a greater chance of having it, then somebody that doesn't have it in their heredity line" (Hemophilia 1). Another way to diagnose it is to run tests on the blood. "One of the screening tests is used to check for primary hemostasis. This test would come back normal if the platelet count, and bleeding time were normal. The second test would check the secondary hemostasis. A normal result would be that there is enough fibrin formed to complete blood clotting. In both tests, negative results would show abnormally low levels of each. Then if they came back negative, the diagnosis would be that they do have Hemophilia" (Description of Hemophilia 1-2). "The prognosis then could be one of the three categories of Hemophilia, they are: mild, moderate, and severe. A person with mild hemophilia may only have problems with bleeding when they have surgery, major dental work, or when they have a severe injury. A person with moderate hemophilia can have the same problems, plus bleeding problems with more minor injuries. A person with severe hemophilia can have what are called spontaneous bleeds. Bleeding that starts inside the body for no reason" (What is Hemophilia 1).
Secondly I will talk about the causes and incidences of hemophilia. The immediate cause of hemophilia is the deficiency of a coagulation factor, used in blood clotting. "Some of the complications of having this disease are: dangerous bleeding episodes, permanent joint damage, and the risk of contracting HIV through a blood transfusion" (Hemophilia 2).
It affects many women during the pregnancy. If not treated, it can cause preeclampsia and lead to death to the mother or fetus. Human reproduction is necessary for the continuation of the human race, but thrombocytopenia threatens the continued health of mothers. This makes thrombocytopenia a very important and necessary disorder to study and investigate. What is Thrombocytopenia?
Rasputin’s loyalty to the czar and his family made him “immune” to the attempts of exile from Russia (DISCovering). Aleksey Nickolayevich was a hemophiliac (Rasputin). On one certain occasion, doctors were called in to check on the young heir. After nothing seemed to help, “Grigory Rasputin, who was reported to have miraculous powers of faith healing, was brought to Alexandra” (Massie 259). Rasputin didn’t cure Aleksey of hemophilia, but his ability to control the symptoms was “indisputable” (Fuhrmann 26). “In December 1916, a group of conservative aristocrats laced Rasputin’s wine with potassium cyanide at a soiree in the Yousoupov Palace” (DISCovering). The poison wasn’t strong enough to kill Rasputin. He was shot once, “lurched” at his attackers and they shot him again (DISCovering).
• Hemolytic disease of the newborn. Hemolytic disease happens when a mother 's disease fighting system (immune system) attacks her baby 's red blood cells. Proteins (antibodies) in the mother’s blood destroy the baby 's red blood cells. Two conditions can cause hemolytic disease:
The severity of hemophilia varies greatly. Hemophilia A and Hemophilia B are the most common genetic bleeding disorders. Hemophilia A is observed in 80 percent of hemophiliacs and is a deficiency or absence of Factor VIII. It can also be referred to as "classic" hemophilia. In the second most common, hemophilia B, factor IX is missing.
Different people define success in many different ways. What is considered success by one person may be viewed as failure by another person. Randy Shilts, a homosexual newspaper reporter / author, attempts to make fundamental changes in America’s opinion on AIDS. In Randy Shilts’s essay, "Talking AIDS to Death," he speaks of his experiences as an "AIDS celebrity." At the core of Shilts’s essay is the statement, "Never before have I succeeded so well; never before have I failed so miserably"(221). Shilts can see his accomplishments from two points of view- as a success and as a failure. Despite instant fame, Shilts is not satisfied with the effects his writings has on the general public. Shilts’s "success" and reasons for failure can both be considered when one decides whether or not his efforts were performed in vain.
Hepatitis is the inflammation or swelling of the liver. The inflammation can happen from different injuries or viral forms of a disease. People who experience hepatitis have the symptoms of malaise, nausea, vomiting, loss of appetite, fever and jaundice. There are six known forms of Hepatitis which are Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, Hepatitis E and Hepatitis G. The presence of hepatitis in the body can be very risky and cause severe death if not taken care of. Hepatitis is a severe issue that affect many people around the world like third world countries and cross contamination can occur mainly in health care places due to the exposure of patients with the disease and accidents handling blood or instruments, Hepatitis A,B,C,D,E and G are distinct diseases that differ in transmission and vaccines to prevent them or cure them.
Throughout Russian history, there were many individuals who captured the interests and curiosity of scholars both domestic and foreign, but one stands out as the most ambiguous. Grigori Yefimovitch Rasputin, the so- called "Mad Monk" or "Siberian Mystic Healer", has gained notoriety throughout the world for his astounding medical feats involving the stopping of the sometimes never ending bleeding of hemophiliacs. In the time of Rasputin, 1864-1916, there were no effective medical means to stop the bleeding that plagued hemophiliacs, yet the mystical powers of one man had the power to do so. Since there were no written records compiled at the time to account for his legacy, the stories of Rasputin have been passed along throughout time by believers and skeptics alike.
Hemophillia is a rare bleeding disorder in which the blood does not clot normally. Hemophillia is usually inherited and people born with it have little or no clotting factor (a protein needed for normal blood clotting). These proteins work together with platelets to help the blood clot. When blood vessels are injured, clotting factors help platelets stick together to plug cuts and breaks on the vessels. Hemophillia usually occurs in males with about 1 in every 5 000 males being born with the disease each year. A hemophiliac does not bleed more intensely than a person without it but can bleed for a much longer time. In some severe cases, continuous bleeding occurs after minor trauma or can even happen spontaneously.They may also bleed inside their body(internally), especially in the knees, ankles, and elbows. The bleeding can damage organs and tissues and may be life threatening. There are two main types of hemophilia: A and B. People born with type A are missing or have low levels of clotting factor VIII (1 in 5 000 males). People born with type B are missing or have low levels of clotting factor IX (1 in 20 000 males). About 8 out of 10 people who have hemophillia have type A. The greatest concern for both types is deep internal bleeding and bleeding into joints. Hemophilia is a life long disease, but with proper treatment and self-care, most people maintain an active productive lifestyle.
Tsar Nicholas II and his Tsarina, Empress Alexandra, had only one son, Tsarevich Alexei. However, Alexei had inherited from his great-grandmother Queen Victoria the life-threatening genetic disease hemophilia B, a sex-linked genetic disease on the X chromosome that caused a condition of deficiency in blood-clotting and excessive bleeding, symptoms that usually remain hidden unless contracted by a male (Fuhrmann 37; King 28). To Nicholas II, it was imperative that he have a son to succeed him to secure the throne. Alexei was Nicholas’s sole male heir, giving Nicholas the incentive to protect his son at all costs. Without a scientific cure for the genetic disease, Alexandra turned to religion, namely Grigori Rasputin, a poor uneducated Siberian peasant to protect her son.
Yearly, around six hundred to nine hundred people are diagnosed with Aplastic Anemia within the United States. Aplastic Anemia is a autoimmune hematological disorder that causes pancytopenia which is a reduction in major blood components, namely, erythrocytes, leukocytes and platelets. This disease has been labelled as a type of bone marrow failure, that is often due to not one but a variety of disorders that occur simultaneously. Aplastic Anemia can therefore be defined as a bone marrow disorder that is often rare, non contagious, and can often be life threatening.
Today i'm going to be talking about Hemophilia and the general overview of it. I will also talk about any potential cures. I will be talking about what Hempohilia can do to your body. I will also be talking about if theres a cure or just a treatment to make it less worse. I will also be talking about how people with Hemophilia deal with this disease. I will also explain how people will benefit from extended research on thi s topic. I’ll also talk about my personal opininon on this topic and what I think about it. So for my first question I’m explaining what the characteristics of Hemophilia are. The characteristics of Hemophilia are not very deadly but can be very annoying I’ll also explan the genetic causes of this disease.
Rodak, B. F., Fritsma, g. A., & Doig, K. (2007). Hematology: Clinical Principles and applications. St. louis: Saunders Elsevier.
Hepatitis In modern society when a person gets sick with the flu or a cold they will usually go about their normal routine with the exception of a sneeze or a cough throughout the day. Sometimes things can be more than what they appear to be. The symptoms start out like the flu with coughing, fever, aches, and vomiting. However, the disease gradually worsens with symptoms of extreme weakness and excruciating abdominal pain. By then it is usually too late when the person finds out that their liver is failing and that there disease is caused by one of the most contagious, dangerous and deadliest of viruses. These viruses that were initially concealed by flu like symptoms are now known collectively as the disease of Hepatitis. The disease of Hepatitis is actually by six different types of viral infections, namely, Hepatitis A, B, C, D, E, and G. Hepatitis descries the destructive affect of the viral invasion of the body and liver by six and separate viruses. Each type of viral infection varies from one to another in degree of severity. The names of the viruses are in alphabetical order corresponding to their discovery. There is also a non-viral Hepatitis which is caused by substance. One rumor that has spread about hepatitis is that a person can only contract Hepatitis if associated with HIV or AIDS. This is not true! Any one can become infected with Hepatitis. Unfortunately this is about all most people know of Hepatitis. They need to know the full horror of which the virus is capable. The first of the Hepatitis viral infection to be discovered is Hepatitis A. Hep. A is the mild mannered virus compared to the other viruses. It has the symptoms of influenza, fever, vomiting, loss of appetite, and weakening of body, but it does have some differences such as jaundice (a yellowing pigmentation of the skin and whites of the eyes) and urine appears to be a darker color. Jaundice is caused by an abundance of bilirubon which has not been removed from the blood system due to the infected liver. Hep. A does not have any special medications or antibiotics that can be used to treat or prevent this unpleasant virus. Some ways of avoiding this viral infection include washing the hands very carefully and not eating food or drink of others. People living in the same house or having close contact should clean the area very thoroughly.
In some cases, this infection can cause a dangerous complication called hemolytic uremic syndrome (HUS).
This disorder is caused by changes in the DNA of cells that make hemoglobin, the substance in human red blood cells that carries oxygen throughout your entire body. This disease is a inheritance disorder passed from parents to children. When parents have low count of hemoglobin and high could of red blood cell it is then transferred to their new born child.