Free Coagulation Essays and Papers

Does Hypothermia Affect Blood Coagulation Enzyme Activity? Blood coagulation: Blood coagulation is a cascade of events that help heal a cut or damaged tissue; it is part of a host defense mechanism termed hemostasis [1] When a vessel, or damaged tissue is affected, macromolecules called platelets are introduced (Sticky molecules that assist to clot a cut to allow blood to once again pass) – With fibrin and plasma to help heal. Of course, there needs to be no abnormalities, such as temperature.

To stop the blood flow after damage, body uses three ways to maintain hemostasis; vascular spasm, platelet plug formation, and coagulation. Coagulation is an important process to prevent loss of blood when blood vessels are cut or damaged. Blood clot is a plug of platelet reinforce with the mesh of fibrin. However, a person with Disseminated intravascular coagulation, DIC, the blood clots have formed throughout the blood vessels when does not necessary. It leads to organ damages due to blocked blood

Disseminated Intravascular Coagulation (DIC) is a complex and progressive multisystemic hemostatic malfunction effecting canines, felines, humans, and other animals (Hackner). DIC is significantly more common in canines than in felines, but the mortality rate in felines is much higher, 93% versus 50-77% in canines (Bruchim, Hackner). This fatal syndrome is not a specific disease but a secondary complication of an underlying disorder (Bruchim). Marked by excessive intravascular coagulation leading to organ

Myocardial infarction is a medical term commonly known as a heart attack.1 According to the British Heart Foundation, there is approximately 103,000 heart attacks in the United Kingdom each year and every seven minutes someone dies of a heart attack.2 Before a suitable treatment can be found, we must understand the factors that cause myocardial infarction and the pathophysiology of the disease. From there we are then able to determine the effective treatments to be given for this disease. By definition

vessel and stop the bleeding. See figure 2. Clotting is also known as coagulation. It begins almost instantly after a blood vessel is injured/damaged. In coagulation blood changes from its natural liquid form to a gel-like form therefore resulting in haemostasis. What is Haemostasis? Haemostasis is the cessation of blood from leaving a damaged/injured blood vessel, and then followed by repair. There are three stages of coagulation: 1) The formation of Prothrombinase. When liquid blood comes into contact

triad of death”(Anthony et al, 2005) and in lieu of this fact, it is important to ascertain the role of temperature on maintaining homeostasis. With this in mind, an experiment to investigate how the temperature of clotting chemicals affect blood coagulation in the circulatory system, specifically in the cases of hyperthermia and hypothermia, and the effects on homeostasis within the body, will be performed. Human homeostasis according to Marieb et al (2007) refers “to the body’s ability to physiologically

respectively. Mutations in these genes trigger the production of abnormal versions or reduce the number of coagulation factors VIII or IX. Subsequently, these missing or scarce proteins are not able to aid in the blood clotting process which causes excessive and continuous bleeding. There are varying levels of the severity of hemophilia which are all dependent on the extent of mutation of coagulation factors VIII or IX (Hemophilia, n.d.). There is, however, another form of hemophilia that is rare. It

therapy (Bluff, et al., 2009). Angiogenesis is the process in which new blood vessels are derived from pre-existing vessels whereas haemostasis refers to the coagulation cascade which causes clot formation (Nijzel, et al., 2006). Various regulators of angiogenesis exist and they may also have effects on numerous components within the coagulation cascade. Two mechanisms exist in which procoagulants can contribute to angiogen... ... middle of paper ... ...(21) and Asp(22). Other activators have

Gene therapy is a not a new field and has been evolving for decades. Even with the best efforts of researchers around the globe, there has only been limited success in gene therapy mainly with the common diseases like cancer. Will gene therapy overcome the diseases that have no other cures? Gene therapy is an experimental technique that treats or prevents diseases through the use of genes. Scientists have focused on diseases that are caused by single-gene defects such as sickle cell anaemia, muscular

Pathophysiology Intaventricular hemorrhage (IVH) is bleeding in the fragile capillaries that develop in the early months of prenatal development and grow stronger the last ten months of a pregnancy. There are four different degrees based on the bleeding and the areas that are damaged. Preterm infants are at a greater risk for bleeding during events that may cause fluctuations in cerebral blood flow because their blood vessels are not yet fully developed. When IVH occurs, the blood may rupture