Glioblastoma Multiforme is the most aggressive and malignant form of brain cancer, with an average survival of less than 12 months. Glioblastomas (GBM) are tumors that arise from the supportive tissues of the brain. These supportive tissues are composed of astrocytes, star-shaped glial cells that play a very important role in neural functioning. Glioblastomas are highly malignant because astrocytes reproduce quickly and are supported by a large network of blood vessels. Although they are generally found in the cerebral hemispheres of the brain, glioblastomas can be found anywhere in the brain or spinal cord. The tumors come from normal brain cells, so it is easy for them to invade and live within normal brain tissue. However, glioblastoma rarely spreads elsewhere in the body. (1) The most common symptoms for GBM are headache, nausea, vomiting, and drowsiness, all caused by increased pressure in the brain. (1) The current strategy for the treatment of Glioblastoma Multiforme is generally palliative treatment, including standard chemotherapy and surgical resection, and radiotherapy. GBM often exhibits a high resistance to both chemotherapy and radiotherapy. (2) Astrocytes are star-shaped glial cells in the brain and spinal cord. They are the most abundant cell of the human brain. Astrocytes provide neurons with metabolic support, control local blood flow, and regulate the maintenance of synapses. They are a critical part of normal neural functioning. (3) The first stage of treatment for glioblastoma is surgery. After surgery, an average GBM tumor is generally reduced 99%. It is used to take a section for a diagnosis, to diminish some of the symptoms of a large mass pressing against the brain, to remove disease before secondary... ... middle of paper ... ... in glioma cells (suppression of autophagy, mentioned above, is often accompanied by activiation of apoptosis). Silencing eEF-2 kinase expression with the inhibitors (NH125) remarkably increased the TMZ-activated apoptosis in human glioma cells. One other important discovery of this experiment was that the combination of TMZ and NH125 did not cause TMZ to destroy normal human astrocytes. Essentially, co-treatment of TMZ with NH125 made TMZ more effective against glioma and produced a better survival benefit for the mice, but could not cure the mice. This may be because the amount of NH125 (eEF-2 inhibitor) used was not enough, or the dosages of TMZ and NH125 were not optimal. Nonetheless, development of better and more effective inhibitors of eEF-2 kinase may help in finding the cure for glioblastoma multiforme, the malignant and extremely aggressive brain tumor.
The exact cause of hypothalamic tumors is not known. It is likely that they result from a combination of genetic and environmental factors. In children, most hypothalamic tumors are gliomas. Gliomas are a common type of brain tumor that results from the abnormal growth of glial cells, which are a type of cells that support nerve cells. Gliomas can occur at any age
The brain is an organ that regulates body functions, behaviors, and emotions. Neurons are the cells that fulfill these functions. How do neurons do this? A neuron plays an important role in the central nervous system. Why? Because neurons regulate how we think, feel, and control our body functions. A typical neuron has three parts: cell body, axon, and dendrites. When a neuron receives an electrical impulse, that impulse travels
Popular beliefs and opinions of the masses in society often become societal norms. Challenges to these societal norms can cause large-scale societal shifts or transitions. Examples of such occurrences include woman’s suffrage, the occupy movement, and falsified racial stereotyping. However, popular opinions, influenced by media, corporations, and members of the community, are sometimes flawed. “Welcome to Cancerland,” written by Barbara Ehrenreich, and “Beautiful Brains,” written by David Dobbs share a similar purpose of debunking common myths and stereotypes of specific social groups. Ehrenreich’s essay states that corporations and community members are popularizing the celebration of the “breast cancer sisterhood,” while stemming the drive
Glia cells are like the “glue”, they support the neurons of the Nervous system by holding them together.
Glioblastoma Multiforme (GMB) is the most common form of primary malignant brain tumor in adults. With the current standard therapy, median survival time hovers just over 12 months. This incurable disease is devastating with a median survival time of 6-8 months from time of recurrence (J10). The current standard of therapy at first diagnosis consists of surgery followed by radiotherapy with concommittant and adjuvant chemotherapy using the agent temozolamide (TMZ) (Multiple sources). In 2003, the United States Food and Drug administration approved the Gliadel Wafer (GW) for treatment of newly diagnosed GBM (C3). The monoclonal antibody Bevacizumab (BEV) was first used to treat recurrent GBM in 2005 and has a significant survival benefit for patients with grade IV glioma (E5). Many more promising avenues for new treatment have been and are currently being studied. Such areas include the use of antiepileptic drugs, using Convection-Enhanced Delivery of chemotherapeutic agents, and targeting specific molecular markers and pathways such as the epidermal growth factor receptor (EGFR), O6-methylguanine-DNA-methyltransferase (MGMT), and the PI3K/Akt/mTOR pathway.
Brain metastases are a common complication of cancer. The incidence of brain metastases is increasing worldwide [2]. About 160,000 to 170,000 of new cases occur per year in the United States. The most frequent types of cancers that tend to develop brain metastases are lung cancer, breast cancer, and melanoma, which account for 67%-80% of all cancers [3]. The most recent population-based study was conducted by Barnholtz-Sloan et al. [4] who used the Metropolitan Detroit Cancer Surveillance System and found the incidence percentage of brain metastases to be 9.6% between 1973 and 2001. Overall, population-based studies show incidence rates of brain metastases ranging from 8.3 to 14.3 per 100,000 population and 8.5-9.6...
According to The Mayo Clinic, “the most common symptoms of a concussion are headache or pressure in the head, confusion or feeling foggy, appearing dazed, fatigue and delayed response to questions.”
Glial cell: Glial cell is a supportive cell in the central nervous system. Unlike neurons, glial cells do not conduct electrical impulses. The glial cells are around neurons and give support for insulation between them. Glial cells are the most efficient cell types in the central nervous system. Types of glial cells include oligodendrocytes, astrocytes, ependymal cells, Schwann cells, microglia, and satellite
Understanding what neuroblastoma is, is critical for a cure with this condition. All cancer involves abnormal cells that grow and divide out of control. Neuroblastoma
According to SEER Statistics, 23,380 people are estimated to get a brain or nervous system cancer diagnosis. Out of those people, 14,320 people are estimated to die from their brain or nervous system cancer diagnosis (National Cancer Institute). Cancer is a type of dangerous tumor, or a buildup of extra cells that form a mass of tissue, that can be life threatening (National Cancer Institute). The term for a tumor that is cancerous is a malignat tumor, whereas a benign tumor does not contain cancer cells (National Cancer Institute). According to the National Cancer Institute, the causes of brain cancer are unknown, but risk factors include family history and excessive radiaton exposure. Although they are not always due to a brain tumor, comon symptoms include headaches, nausea, speech, hearing, vision, and mood changes, problems with balance and mamories, seizures, and numbness in arms and legs (National Cancer Institute). MRI and CT scans as well as surgical biposies (or the removal of part of the tumor to be examined) are used to diagnose brain cancer (National Cancer Institute). Different types of treatment options include radiation therapy, surgery to remove the tumor, and chemotherapy. According to Charles Davis, MD, PhD and Nitin Tandon, MD of WebMD.com, chemotherapy is “ the use of powerful drugs to kill tumor cells”. There are a few different types of chemotherapy, but all of which bring out the same kinds of side effects. Although the physical side effects of chemotherapy are commonly known, few people know of the emotional toll chemotherapy can take on a patient and his or her family as they go though this process.
I was a child when my aunt got sick, and my fascination about the field of medicine began. She had brain cancer. While I watched the disease progress I was flooded, not only with sadness and grief, but with questions. With two psychologists for parents I had a lot of support and understanding of my feelings, but I was left curious about the medical aspect of the disease and why there was no cure. The notion that the brain could change someone’s entire personality and physical function was amazing to me. Spending a lot of time in hospitals, I observed so much about the impact of a cancer diagnosis on patients and their families, and about what happens to people through the disease process. I noticed the enormous influence that the medical professional’s
Neurons and glia (cells that support neurons) are specialized cells for electrical signaling over long distances. Understanding neuronal structure is important for understanding neuronal function.
The neuron plays an important role in the occupation of the brain (Rollin Koscis). A neuron is...
The brain consists of both neurons and glia cells. The neurons, which are cells housed in a cell body called a Soma, have branches which extend from them, referred to as dendrites. From these dendrites extend axons which send and receive impulses, ending at junction points called synapses. It is at these synapse points that the transfer of information takes place.