Cervical Dystonia

The injection of botulinum toxin, generally known as Botox, has become very popular for reducing wrinkles and restoring the aging face. Botulinum toxin is a strong neurotoxin that inhibits acetylcholine released at the neuromuscular junction. This neurotoxin is used in various disorders including cervical dystonia. Two preparations of botulinum toxin, Dysport and Botox, are now commercially available. The purpose of this study was to evaluate the effectiveness of Botox with two different ratios of Dysport.
Botulinum toxin is a potent neuromuscular paralyzing agent that blocks the release of acetylcholine leading to immobility of the muscles. Two preparations of botulinum toxin type A are now available: Dysport and Botox. The efficacy of both have been shown in various disorders.
Both Botox and Dysport work in a similar

In a European study, the prevalence of cervical dystonia in patients over 50 years of age was 732 per 100,000, indicating that current prevalence of primary dystonia may be considerably greater than the rates reported. In a recent study, the incidence of CD was greater in Caucasian individuals and twice as high in women than in men. For this cross over study, the sample size was calculated on a similarity between treatments defined by a difference in the post treatment Tsui score of 1.5 points or less. For this randomized study, Dr Danoux and colleagues ran an ANOVA test. After completion of the test, no significant difference was detected in baseline scores according to the order and types of injections. The mean improvement of the Tsui score reported was 3.22 for Botox, 4.32 for Dysport 1:3, and 4.89 for Dysport 1:4, showing that not only the three treatments were effective but that both Dysport 1:3 and 1:4 were more effective than Botox. However, there was no major difference between Dysport 1:3 and Dysport