Osteoblasts, osteoclasts and osteocytes are three major bone tissue regeneration related cells that contributes to the completion of injury healing. Differentiated from Mesenchymal stem cells (MSCs), the major function of osteoblasts is to build bone extracellular matrix (ECM), known as osteoid, by producing and secreting organic compounds, such as Type I collagen. Osteoblasts are also involved in mineralization, where osteoblasts secret alkaline phosphatase that modify the phosphate groups to be the mineral deposition foci . During bone formation, osteoblasts have two pathways to follow. One of these two is to become trapped in the matrix secreted by osteoblast itself and differentiate into osteocytes and the other is to undergo a programmed cell death, termed apoptosis . Osteoblasts affect the skeletal architecture in two major aspects: bone matrix depo...
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...): p. 412-20.
10. DePalma, A.F., et al., Anterior interbody fusion for severe cervical disc degeneration. Surg Gynecol Obstet, 1972. 134(5): p. 755-8.
11. Kalfas, I.H., Principles of bone healing. Neurosurgical Focus, 2001. 10(4): p. 1-4.
12. LaStayo, P.C., K.M. Winters, and M. Hardy, Fracture healing: bone healing, fracture management, and current concepts related to the hand. J Hand Ther, 2003. 16(2): p. 81-93.
13. Marsell, R. and T.A. Einhorn, The biology of fracture healing. Injury, 2011. 42(6): p. 551-555.
14. Dimitriou, R., E. Tsiridis, and P.V. Giannoudis, Current concepts of molecular aspects of bone healing. Injury-International Journal of the Care of the Injured, 2005. 36(12): p. 1392-1404.
15. Gerstenfeld, L.C., et al., Three-dimensional reconstruction of fracture callus morphogenesis. Journal of Histochemistry & Cytochemistry, 2006. 54(11): p. 1215-1228.
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