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History of rabies in humans
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Rabies : The Virus and Its Mechanisms
Rabies is an infectious disease that has been around the world since the time of Columbus and his first trip to the New World. Back then, it was characterized as the “mad dog” disease and only few would survive it. Those who survived, it was said, were due to miracles. Rabies is a disease that attacks and infiltrates the nervous system and ultimately attacks the brain of its host, leading to neuronal dysfunctions. Throughout the years, scientists have studied the virus with deep interest, as some of its qualities are known, and others are not. Being a complex virus, there are many things that attribute to its life cycle, each with a unique purpose that leads to the complete attack of the host affecting its nervous system, salivary glands, and some of the major organs of the body.
The rabies virus comes from the genus Lyssavirus and family Rhabdoviridae, and has an exceedingly similar “morphology, chemical structure, and life cycle to vesicular stomatitis virus.” (Jackson 23) Its genus and family taxation come both from Greek roots that mean “rage” and “rod” respectively. Rabies is a “zoonotic” disease, which means that it can be transferred from animals to humans and vice versa. The main mission of this destructive virus is to penetrate the nervous system of its host and invade the central nerve cells. Once there, it will replicate itself, until it finishes with a process referred to as budding, which punctures and blows up the cells, essentially destroying the nervous system. Thus, by attacking the central nervous system the virus will penetrate the brain cells and invade other systems and organs. (Jackson 342)
Rabies, RABV, is a commonly known disease throughout the world. Many instantl...
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Bibliography
Jackson, Alan C., and William H. Wunner. Rabies. London: Elsevier Science, 2002.
Jackson, Alan C., and William H. Wunner. Rabies: Second Edition. London: Elsevier Science, 2007.
Wong, Derek. "Viral Zoonoses." Rabies (2004) 27 Jul 2008 .
Harper, Tara. "Virology Notes." Rabies (2004) 27 Jul 2008 .
Gompf, Sandra. "Medical Topics." Rabies (2006) 22 Jan 2007 .
Johnson, Mark. "Teen, her doctors adjust to spotlight’s glare." Jeanna Giese struggles to be ... just your normal rabies survivor 26 Nov 2005 18 Jul 2008 .
Hunt, Margaret. Virology Lecture (2000) < http://www.thailabonline.com/virus3.htm>
In the United States there was a vicious enemy everyone feared. In the 1950s the United States was under attack by the ruthless Poliomyelitis virus. Americans lived in constant fear of their children contracting this horrible virus that left many children paralyzed. During the outbreaks in the 1950s foundations were created to fund research and create awareness to help find a way to eradicate the virus. Americans become focused on doing anything in their power to fight this virus off. Jonas Salk’s Exploration of Medicine and research led to the creation of the Polio vaccine that united the country, prevented further outbreaks, and introduced a new form of treatment which has limited the fatality of polio infections today.
Barbara Anderson’s husband (Thor), her daughter (Katie; 5yrs old), and Anderson’s unborn child (Sarah) accompanied her to her field site.
Almost 2,000 died the night of the 1928 storm in Florida. Their Eyes Were Watching God by Zora Neale Hurston realistically depicts the Okeechobee hurricane that struck the coast of South Florida. The incredulous, category four storm produced winds as high as 150 mph and flood waters of up to eight feet. Hurston describes their heart wrenching experience throughout the end of the novel when Janie, the protagonist of the story, survives the devastating hurricane with her husband, Tea Cake. The book shows similarities between the overflow of Lake Okeechobee and the specific weather conditions of the hurricane, but differs regarding the aftermath of the storm.
Chronic Wasting Disease (CWD) is a fatal neuro-degenerative, transmissible spongiform encephalopathy (TSE) of the family Cervidae (Hamir, et.al., 2006). The family Cervidae includes mule deer, Odocolileus hemionus, white-tailed deer, Odocolileus virginianus, Rocky Mountain elk, Cervus elaphus nelsoni, and moose, Alces alces shirasi, among others (Sigurdon & Aguzzi, 2007). CWD is a prion disease, meaning it is a protein caused infection, that occurs naturally in the deer family (Song & Lawson, 2009). This protein is suspected to be an abnormal isoform (PrPSc) of the naturally occurring host prion protein (PrPC) (Blanchong, et. Al., 2009). Bovine spongiform encephalopathy (BSE), mad cow disease, is a similar prion effecting cattle as CWD affects Cervidae. Although, scientists are not sure of transmission route it is suspected that CWD is transmissible and infectious through direct contact with infected individuals or through environmental contamination (Song & Lawson, 2009). Tests have been performed showing susceptibility of altered mice to oral transmission, mimicking the suspected route of entry, and the incubation appears slower but lasts longer with oral infection (Trifilo, et.al., 2007). The approximate time from the initial infection to death is three years.
Vaccine safety is one of the most controversial topics in today’s public discourse. Everyone has heard of them, but few know why they are so encouraged. A vaccine contains a weak or dead version of a microbe. This creates a small scale invasion of the immune system, which activates cells to destroy the microbe. Once these cells have been made they are always there to provide protection. This protection is immunity, for those cells are then able to recognize any live version of the same microbe and attack it immediately. This can save lives but also be dangerous, vaccines carry many other components which can cause side effects. These could be simple adverse effects such as a small cold or, in the rare case,
Polio is a viral disease. It cripples thousands of people and infects even more every year. Even though millions are inoculated, and the polio disease has been successfully purged from hundreds of countries still thousands of people and developing countries are infected and still people are dying. According to the World Health Organization (WHO) polio affects the Central Nervous System, or CNS; by infesting the intestines and transmitting it into the nerves thought the blood vessels. There the virus spreads through the nerve cells to the brain stem or other motor units, while forever damaging the nerves.
Rabies does not discriminate against any warm blooded mammal; all that come into contact with the virus are at risk. Those who choose to live, work, and recreation in areas with a larger wildlife population are understandably at higher risk. People should be extremely wary of unknown animals and heed behavior changes in familiar animals. The virus is usually spread from a bite wound when the saliva of an infected animal is introduced to the victim via the bite. The virus travels from the origin of the wound to nerves and onward to ultimately infect the brain.
A “vaccine” or otherwise known as a vaccination, is something that stimulates someone’s immune system from a disease. Vaccines can prevent infections and actually cause it to not re-occur again. The invention of the Rabies, and Anthrax vaccines not only saved life’s, but helped scientist conduct and produce more accurate and successful research. Discovered by Louis Pasteur, in 1882, the innovation of the rabies vaccine was invented. Rabies is a critical and sometimes fatal infection that one could get with coming in contact with a “rabid” or wild animal. When this virus enters the body and spreads, it travels slowly through all the nerves and all the way to the brain. Once it reaches the brain, it becomes fatal. The number of deaths due to rabies worldwide each year is approximately 55,000. However, due to the invention of the rabies vaccine, the number of fatalities and illnesses decreased by a substantial amount.
Brunet, Thierry. A Lightning Strike On The Retina. SPIKE Magazine < http:// www.spikemagazine .com/1199hubertselby.htm> 21 October 2003
In a 2008 study in the journal Alternatives to Laboratory Animals shows that over 80 HIV/AIDS vaccines that worked in nonhuman primates were unsuccessful in human trials. In a 2004 study in the journal Stroke, over 4,000 studies report the intended result of more than 700 treatments of stroke in animal models. Although, none of the approximately 150 of these treatments tested in humans showed clinical benefit. This was recorded in a 2005 paper in the International Journal of Neuroprotection and
Rabies is a deadly virus that occurs in the brain. It can affect all mammals but the ones that are most commonly found with the virus are dogs, bats, raccoons, skunks, and coyotes. This means that any non-mammal can not contract the virus, such as fish, birds, and reptiles (2). The virus can be contracted by humans with saliva transfer with broken skin contact from an animal which has the disease. As this is the most common form of transferring the disease it is very believable that Tea Cake contracts the virus from the wild dog that “managed to bite [him] high up on his cheek bone once” (1). The rabies virus works by being a bullet shaped virus that directly attacks th...
Polio: An American Story describes a struggle to find a vaccine on polio through several researchers’ lives, and over the course of many years. The second thesis is the struggle between Salk and Sabin, two bitter rivals who had their own vaccine that they believed would cure polio. The author David M. Oshinsky, is describing how difficult it was to find the cure to a horrifying disease, which lasted from the Great Depression until the 1960’s. Oshinsky then writes about how foundations formed as fundraisers, to support polio research. Lastly, the author demonstrates how researchers were forced to back track on multiple occasions, to learn more about polio.
the virus also needs a way to get rid of your ability to know right from wrong, have memory and to have any feelings which in your brain is called serotonin,tryptophan,amygdala, and acetylcholine. Now we have a human with no feeling of satisfaction , happiness, sadness, or really anything. The human is essentially brain dead.(http://www.nimh.nih.gov/health/educational-resources/brain-basics/brain-basics.shtml),(http://www.buzzle.com/articles/chemicals-in-the-brain.html,Mehta Suketu,last update:october 1st,2011.).
Krupnick, Ellie. "Talia Joy Castellano, 12-Year-Old Cancer Patient, Creates Youtube Makeup Tutorials." The Huffington Post. TheHuffingtonPost.com, 08 Aug. 2012. Web. 24 Mar. 2014.