2.4. CURCUMIN ADMINSTRATION Curcumin (Sigma Aldrich, St Louis, USA) at 40 mg/kg of body weight was dissolved in one ml sesame oil by proper shaking of the tube. We did not observe any change in color of the solution during the experiment (23). The rats in the control group did not receive any treatment, and subjected to the PBM, in which the radiating probe was turned off. 2.5. CLINICAL OBSERVATIONS The rats’ weight was watched throughout the study. Every day, the wound site was examined properly for recording probable apparent exudation. 2.6. MEASUREMENTS OF WOUND AREA In order to compare wound closure among study groups, wound area was measured. The wound area measurements included measurement of the total wound area on the days 4, 7, …show more content…
STATISTICAL ANALYSIS All the data were expressed as mean ± standard deviation of the mean (SD). The student t test, one-way and two- way analysis of variance (ANOVA), and the least significant difference (LSD) tests were used. The p-value of <0.05 was accepted. 3.RESULTS 3.1. Wound closure, Day 4 The curcumin (197±14), laser (243±20), and laser + curcumin (231 ±33) treated groups significantly enhanced wound closure. compared to the control group (329 ±6.7),(One-way ANOVA, LSD test for all groups, p=0.000). We have observed that the curcumin group had significantly enhanced wound closure, compared to the laser, and laser + Curcumin treatedgroups ( LSD test, p=0.009, p=0.040, respectively)(Figure 2). 3.2. Wound closure, Day 7 The curcumin (69±8.7), laser (85±12), and laser + curcumin (88 ±7.9) treated groups significantly enhanced wound closure, compared to the control group (139.8 ±20.2), (One-way ANOVA, LSD test for all groups, p=0.000). We have observed that the curcumin treated group had significantly enhanced wound closure, compared to the l aser + Curcumin group ( LSD test, p=0.033)(Figure2). 3.3.Wound closure, Day …show more content…
Laser and curcumin groups showed a significant decrease, compared to laser + curcumin groups (LSD test, both p=0.001). On day 15, the Laser (10±5), curcumin (14±4.5), and laser + curcumin (27.3 ±8.3) groups have significantly decreased CFU, compared to the control group (95 ±6), (LSD test, all p=0.000)(Figure 3). Laser and curcumin groups showed a significant decrease in CFU than laser + curcumin groups (LSD test, p=0.009, p=0.030, respectively). The two-way ANOVA table gives F statistics =286 with sig = 0.000 for the factor group (4); F statistics 10.5 with sig = 0.005 for the factor after surgery time points (two); and F statistics 6.6 with sig = 0.004 for the interaction effect of after surgery time points × study groups. We found significant differences in CFU among control and other groups, and also between laser, and curcumin groups and laser + curcumin treated group (Figure 4). It means regarding the microbiology, results of laser and curcumin groups were statistically better than laser + curcumin
It regulates the ratio between epithelial cells and collagen fibers as well as changes in their morphology. The imbalance of collagen metabolism and its arrangement is attributed to many factors which result in increased synthesis of collagen by fibroblasts and myofibroblasts, which in turn inhibit the activity of collagenase, leading to extensive scar hyperplasia. Matrix changes, mainly changes in fibronectin and mucopolysaccharides, result in scar stiffness. MEBO Scar Ointment can accelerate the re-arrangement of twisted collagen andreduce proliferation of fibroblasts, thus restricting scar hyperplasia. [11,13,14,15 ,21] The accumulation and synthesis of mucopolysaccharide can also be reduced once local tissues are compressed, thus reducing generation of collagen and the corresponding scar tissue. [11] Moreover, massaging the MEBO Scar ointment onto old scars can potentially reduce blood supply within scars, decrease synthesis of collagenous fiber, and,reduce α2-M (alpha 2-macroglobulin) globulin of collagenase in serum which facilitates collagenase activity and speeds up disintegration of collagen in old scars,this facility by applying MEBO scar ointment .
The calculated result from the chi-square test gave a p-value of .0015. The null hypothesis was rejected and the alternative hypothesis was accepted because the p-value was less than .05. The
A pressure ulcer is an area of skin with unrelieved pressure resulting in ischemia, cell death, and necrotic tissue. The constant external pressure or rubbing that exceeds the arterial capillary pressure (32mmHg) and impairs local normal blood flow to tissue for an extended period of time, results in pressure ulcer (Smeltzer et. Al., 2013). According to National Pressure Ulcer Advisory Panel, 2014, pressure ulcers are a major burden to the society, as it approaches $11billion annually, with a cost range from $500 to $70,000 per individual pressure ulcer. It is a significant healthcare problem despite considerable investment in education, training, and prevention equipment. This paper includes two different studies to link cause-effect
...urage healing but also commendable for the treatment of all types of superficial wounds in which the main significant concern is excess exudate. Though, “in a study of these types of superficial wounds, it is difficult to demonstrate that one material is superior to another in terms of wound healing” (Kim & Lee et al., 2013).
CO2 lasers have been popular in oral surgery due to their precise incisions and excellent hemostasis. It is commonly used laser for incisional & excisional biopsies.(PecaroBC,GarchumeWJ.The CO2 laser in Oral and maxillofacial surgery. J.OralMaxillofacSurg 1983.41:725-728ii.clinical application of the CO2Laser in Laser in dentistry …Ch.10 p145.
Vitamin C: Vitamin C helps to stimulate production of collagen and this will help heal wounds. Vitamin C also helps in the production of elastin which is importance to allow wounds to stretch without causing further damage. Vitamin C can be found in fruits such as lemon and oranges as well as peppers, cabbages, cauliflower and
Each study had a combination of strengths to support the importance of NPWT in healing diabetic foot ulcers. It was also shown that each article was valid, relevant, and peer-reviewed in the support of this need of new methods (NPWT) in improving the patients’ quality of life. The majority of the literature reviewed had a high degree on internal validity through the use of randomized control studies. According to Jarrett (2013), “a high degree of internal validity can be achieved through random control studies because of the decrease in bias that could develop is decreased”. Even though the three systematic reviews supported NPWT, there could possibly be internal threats if the researchers had any personal bias in the selection of studies reviewed. All the articles met the inclusion criteria needed for this proposal. Six studies were excluded due to either being too broad or too inconclusive and could potentially cause errors in the data. Selection bias does not appear to be a factor as the research methods used shows no history of bias in any of the random groups made. Overall, the internal validity is strong. The external validity of this research (NPWT) can be used with all patients’ that have diabetic foot ulcers. Steps were taken to control characteristics that could impact outcomes when considering the sample group such as bias by the
Carbon dioxide laser, a recent development, emits extremely high energy. It vaporizes the scarred skin tissue layer leaving fresh skin behind. The benefit of this process is that very less medical complications are associated with this.
Study Design: Case studies were designed to determine whether leeching procedures would affect patients with chronic pain, and by what amounts. These were patients aged from 13 to 96 that were defiant to usual tradition procedures. Five case studies were made. The case studies were performed on two elderly patients; one diagnosed with RSD , and the other patient suffering from burnings, oedema and hyperesthesia. Three other patients were also treated; a 16-year-old adolescent also with RSD and a severe hypertrophic scar, as well as a patient with Berger’s disease and a war veteran with ‘scrape metal wounds’.
A wound is an injury to living tissue caused by a cut, blow, or other impact, typically one in which the skin is cut or broken. The skin is the body’s largest organ, making up 15% of the human body. It is responsible for temperature and protection of the body from various external influences. Wound healing is the normal body response to injury, either surgical or traumatic, causing disruption of the integrity of tissues. Surgical wounds are classified according to their degree of microbiology (2014 Advanced Tissues).
Laser skin resurfacing may not be for everyone. If laser resurfacing is the best treatment for you, we may ask you to avoid taking any dietary supplements, aspiring, vitamin E or ibuprofen for 10 days before the treatment. If you smoke, you should quit at least two weeks before treatment because smoking inhibits healing. If you have issues with fever blisters or cold sores, you should inform our specialist. The treatment is an outpatient procedure, and you can go home afterwards.
Abstract: The laser is gaining increasing popularity in the medical field because of its broad application, efficiency, and improvement in overall ease of the procedures in which it is used.. The laser can treat an enormous range of ailments. The chronic nighttime snorer can give those around him relief by a simple procedure with the laser. In dermatology, the laser can be used for removing moles, tattoos, birthmarks, treating wrinkles, and possibly destroying skin cancer. The once dreaded trips to the dentist may become less painful since the laser is helping to replace the drill and Novocain. The laser also is becoming increasingly popular in orthopedics for treating shoulder, knee, and back ailments. For women many gynecological problems ranging from infertility to endometriosis can be treated with the laser. For small, precise work the laser is indispensable such as in the eye. Unfortunately, since laser medicine is still rapidly developing, it has experienced its pitfalls in some areas like cardiology. Overall, the laser is an invaluable substitute for the scalpel of the past, and the laser's possibilities for the future are broad and promising.
When a wound is determined as non-healable, as described by Sibbald et al (1), it should not be treated with a moist treatment and should be kept dry in order to reduce the risk of infection that would compromise the limb. It is also important to consider the patient 's preferences and try to control his pain, his discomfort in activities of daily living and the odour that their wound may produce. In this case, special attention must be given to infection prevention and control. Some charcoal dressing would be interesting in the care of our non-healable wounds at St. Mary 's Hospital.
The wound-healing process consists of four highly integrated and overlapping phases: hemostasis, inflammation, proliferation, and tissue remodeling or maturation (2). These phases and their biophysiological functions must occur in the proper order, at a specific time, and continue for a specific duration at an optimal intensity. There are many factors that can affect wound healing which interfere with one or more phases in this process, thus causing improper or impaired tissue repair (3).
The medical literature on treating wounds with honey has been reviewed recently in specialist wound-care journals, with a focus on the medical evidence (Molan, 1998) and with a focus on the clinical aspects (Molan, 1998). In the numerous reports in the medical literature on the use of honey as a wound dressing the types of wounds on which honey has been successfully used are very varied. Of particular note are the successful uses of honey to treat Fournier's gangrene (Subrahmanyam,1993) a rapidly spreading infection that is usually managed by aggressive surgical removal of infected tissue which are difficult to treat because they are in a position where it is difficult to prevent infection occurring. Also application of honey to wounds especially to chronic wound has been seen to heal faster unlike when some antibiotics are used. (Watts, R; Frehner, E, 2017). However, the therapeutic effects of the honey that have been observed has proven effective on different types