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Smallpox history research paper
Research paper in epedmic of smallpox before 1660
Effect of smallpox
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Variola major: its symptoms and the possibilities of its use in bioterrorism
Smallpox is a virus that was pronounced eradicated in 1990 by the World Health Organization (WHO). Prior to its elimination through the coordinated efforts of several international agencies, it was considered one of the most dangerous threats to the prolonged existence of the human race. Its effects, especially those of the hemorrhagic strain, are comparable to those of such agents as the Zaire Ebola virus, Lassa hemorrhagic fever, and Marburg virus.
EPIDEMIOLOGY
Smallpox (Variola major) spreads through either direct physical contact or prolonged proximity to an infected individual. The disease begins in the lungs, spreading from there to the rest of the body.
Men and women are equally susceptible to the disease, as are all ethnicities. Of those who came in contact with the disease, few survived. The mortality rates are these:
Discrete ordinary smallpox: 34%
Confluent ordinary smallpox: 59%
Hemorrhagic smallpox: 94%
Smallpox was known to nearly wipe out entire populations, and often decimated communities, cities, and countries.
POSSIBLE BIOWARFARE USES
FIRST USE
The first recorded use of smallpox as a biological weapon was in 1756. Sir Jeffrey Amherst and other members of the British colonial army gave blankets that had previously belonged to smallpox victims to American Indians, causing them and their tribes to contract the disease previously unknown to them. In some areas, more than 50% of the population perished.
WORLD WAR II
During the second world war, the Axis decided to begin the usage of biological weapons in order to assure that the war went in their favor. This task was assigned to Japanese Military Unit 731, which recruited numer...
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...(2005) Biological weapons defense: infectious diseases and counterbioterrorism. New York: Humana.
Smallpox. (2006, July 30.) Retrieved July 30, 2006 from http://en.wikipedia.org/ wiki/Smallpox
Centers for Disease Control and Prevention. (2006) What you should know about a smallpox outbreak. Retrieved July 30, 2006 from http://www.bt.cdc.gov/agent/ smallpox/basics/outbreak.asp
United States Department for Health and Human Services. (2006) Smallpox: About the disease. Retrieved July 30, 2006 from http://www.hhs.gov/smallpox/About Disease.html
World Health Organization. (2006) Smallpox. Retrieved July 30, 2006 from http://www.who.int/csr/disease/smallpox/en/
World Health Organization. (2006) Report from the Secretariat: Smallpox eradication - destruction of smallpox virus stocks. Retrieved July 30, 2006 from http://www.who.int/gb/ebwha/pdf_files/EB117/B117_33-en.pdf
18) Powell, Alvin. "The Beginning of the End of Smallpox."news.harvard.edu. N.p.. Web. 13 Mar 2014. .
“Future nations will know by history only that the loathsome smallpox has existed and by you extirpated”. This quote comes from Thomas Jefferson to Edward Jenner, he founder of the smallpox vaccine. It would only be 100 years later that Jefferson would see his dream fulfilled, but not without struggle. In House on Fire, author William H. Foege shares his first hand view of the lengths that society needed to go through to rid the world of the disease that had plagued it for so long. The story of the fight against smallpox extends long before our efforts for global eradication and is a representation of how society deals with widespread disease. House on
The Demon in the Freezer by Richard Preston is an intriguing book that discusses the anthrax terrorist attacks after 9/11 and how smallpox might become a future bioterrorist threat to the world. The book provides a brief history of the smallpox disease including details of an outbreak in Germany in 1970. The disease was eradicated in 1979 due to the World Health Organization’s aggressive vaccine program. After the virus was no longer a treat the World Health Organization discontinued recommending the smallpox vaccination. In conjunction, inventory of the vaccine was decreased to save money. The virus was locked up in two labs, one in the United States and one in Russia. However, some feel the smallpox virus exists elsewhere. Dr. Peter Jahrling and a team of scientists at the U.S. Army Medical Research Institute of Infectious Diseases in Maryland became concerned terrorists had access to the smallpox virus and planed to alter the strain to become more resistant. These doctors conducted smallpox experiments to discover more effective vaccines in case the virus were released. Preparedness for a major epidemic is discussed as well as the ease with which smallpox can be bioengineered.
Guillemin, J. (2005). Biological weapons: From the invention of state-sponsored programs to contemporary bioterrorism Columbia University Press.
One of the determining factors of a person’s survival from the variola virus during the period of the American Revolution in North America was race. Even though the variola virus in and of itself does not factor in race to determine whether to infect one person over another, race did factor in significantly in the survival rate when exposed to the virus. Part of Fenn’s argument is that Europeans had an innate immunity over diseases that those who were not from Europe did not have. She argued that since Europeans come from a world with a large array of diseases their bodies had built up certain protections against the variola virus. This innate immunity that Fenn discussed brought about certain mechanisms within the body that pr...
Eradication is the concept that a disease is entirely eliminated in a region. (Carter n.d.) Only one infectious disease to date, smallpox, has been categorized as eradicated worldwide (CDC 2010). How did this eradication occur? From 1958 to 1965 all fifty states enacted legislation to mandate school age children receive the small pox vaccine (College of Philadelphia). Consequently, by 1971, no small pox cases had been reported in the United States for 20 years. The last known smallpox case in the world was in Somalia in 1977 (CDC 2010). Even though small pox is the only listed eradicated disease, the Carter Foundation has listed six other diseases as having the potential to be eradicated: lymphatic filariasis (Elephantiasis), polio, measles, mumps, rubella, and pork tapeworm. In addition to these previous listed diseases are to date the following diseases which are considered preventable by vaccination: chicken pox, diphtheria, Haemohphilus Influenza type B, Hepatitis A and B, HPV, Influenza, Measles, Meningococcal Disease, Mumps, Pertusis, Pneumonia, Polio, Rotavirus, Rubella, Shingles, Smallpox, Tetanus, Yellow Fever, and STDs (Carter n.d.).
Native Americans were completely susceptible to contracting the disease, but they weren't the only victims. Twenty people died on the Mayflower as a result of smallpox. There was a smallpox outbreak in Plymouth Colony around 1633. Twenty people died including their only physician. This was the beginning of the colonial's struggle with the disease.
In order to understand the history of smallpox one first has to understand how diseases like it evolve. Much like other species, diseases that survive in the long run are the microbes that most effectively reproduce and are able to find suitable places to live. For a microbe to effectively reproduce, it must "be defined mathematically as the number of new infected per each original patient." This number will largely depend on how long each victim is able to spread the virus to other victims (Diamond, 198).
From 166 A.D. to 180 A.D., The Antonine Plague spread around Europe devastating many countries. This epidemic killed thousands per day and is also known as the modern-day name Smallpox. It is known as one of deadliest plagues around the world.
It began with infection mainly in the blood vessels of the human skin and mouth, resulting in different kinds of symptoms that turn into serious stages. It was spread by physical contact with human skin and mostly affected children and adults. This disease was so outrageous that it led to a vast number of deaths in New England colonies. Also, smallpox virus is transmitted through airborne infection from the oral, nasal mucus of the infected person. But mostly was spread from close contact or contaminated material of the infected person.
Henderson, Donald A., et al. “Smallpox as a Biological Weapon: Medical and Public Health Management.” Journal of the American Medical Association 281.22 (June 1999). 24 July 2008 .
diseases in the world, and it was declared eradicated in 1980 (Smallpox). This and all the other
Until its eradication, smallpox was a disease that had been ravaging the human race for a very long time. It emerged as much as 10,000 years ago, probably in the Nile Valley and what is now the Middle East. This emergence occurred around the time that humans began to create farming communities and turn away from nomadic existence, thus allowing the smallpox virus a chance to move from person to person (Ogden 2). Since that time, outbreaks have occurred in all different regions of the globe, although the disease was not introduced into the New World until 1518 when a Spanish ship landed on the island of Hispaniola, thus wiping out half of the population. The Spanish sailors had previously been infected by a strain of the smallpox virus and were therefore immune. The natives, however, had never been exposed to the virus and their bodies were unable to fight it off at all. It is thought that as much as 90 percent of the native populations of the New World were killed by smallpox in conjunction with the other previously unseen diseases that were brought over by explorers (Ogden 3).
...cy on biological warfare. During his visit to Fort Detrick, he announced that the United States would terminate all research on biological weapons. By the year 1972 the United States had completely destroyed all biological weapon stockpile. In return of this act the Biological and Toxin Weapons Convention was held, As a result of 118 countries signed a agreeing not to develop, produce, or stockpile any form of biological weapon(Mayer p4). Unfortunately despite many laws passed over time, few countries have abided by them. Evidence of this came in the late 1970’s and early 1980’s there were reports that the Soviet Union was using biological weapons in Laos, Kampuchea, and Afghanistan (Mayer p 4).