Bioterrorism: Smallpox
Smallpox is a highly infectious and fatal disease caused by the Variola virus. It causes extremely painful pustules to sprout across the entire body. Spread from human to human, it has since been eradicated from the world through the efforts of the World Health Organization. However, there is a distinct possibility that it may be reintroduced through bioterrorism. Biological weapons may cause another pandemic to erupt across the world and kill millions of individuals. Through constant vigilance and careful planning, mankind can prevent this scenario.
During the course of human history, pandemic diseases have threatened the balance of civilization itself. Viruses, bacteria, fungi, and other infectious agents have changed the way we eat, sleep, and live our lives. One of these scourges was smallpox, a highly infectious and deadly disease that causes boils to sprout on the entire body. Once endemic to the entire world, it has been wiped out with mass vaccination efforts by the World Health Organization with the last reported case being in 1977 in Somalia (Tucker 118). The threat of the virus still looms over us, however, with the advent of the age of terrorism. Its transmission method (human to human), the lack of effective treatment, its high mortality rate, and its ease of weaponization has compelled the Centers for Disease Control to classify it as a Category A bioterrorist agent with the highest potential for use as a weapon against civilians (Ryan 41).
The smallpox disease is caused by the Variola virus, a virus of the Orthopox family, which also includes cowpox, monkeypox, and other related diseases (Tucker 5). Two variants
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have appeared; Variola major, the more common and deadly form, and Vario...
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Henderson, Donald A., et al. “Smallpox as a Biological Weapon: Medical and Public Health Management.” Journal of the American Medical Association 281.22 (June 1999). 24 July 2008 .
Medical College of Wisconsin. “Facts About Anthrax and Smallpox as Bioterrorism Weapons.” Healthlink. 12 Nov. 2001. Medical College of Wisconsin. 24 July 2008 .
Ryan, Jeffrey R., and Jan F. Glarum. Biosecurity & Bioterrorism: Containing and Preventing Biological Threats. Oxford: Elsevier Inc., 2008.
Tucker, Jonathan B. Scourge: The Once and Future Threat of Smallpox. New York: Atlantic Monthly Press, 2001.
World Health Organization. “Smallpox.” World Health Organization. 24 July 2008 .
This summer we had an opportunity to dive into the world of bioweapons, through Richard Preston’s novel The Demon in the Freezer. His book explored the colorful world of smallpox and its use as a biological weapon. Earlier this week we were graced with this authors present for an ACES event. He discussed some of the found topics in his book such as animal testing, what small pox is, and even its eradication. One of the great things we had the chance of vocalizing were our many opinions on the gloom associated with this intriguing disease.
“Future nations will know by history only that the loathsome smallpox has existed and by you extirpated”. This quote comes from Thomas Jefferson to Edward Jenner, he founder of the smallpox vaccine. It would only be 100 years later that Jefferson would see his dream fulfilled, but not without struggle. In House on Fire, author William H. Foege shares his first hand view of the lengths that society needed to go through to rid the world of the disease that had plagued it for so long. The story of the fight against smallpox extends long before our efforts for global eradication and is a representation of how society deals with widespread disease. House on
The Demon in the Freezer by Richard Preston is an intriguing book that discusses the anthrax terrorist attacks after 9/11 and how smallpox might become a future bioterrorist threat to the world. The book provides a brief history of the smallpox disease including details of an outbreak in Germany in 1970. The disease was eradicated in 1979 due to the World Health Organization’s aggressive vaccine program. After the virus was no longer a treat the World Health Organization discontinued recommending the smallpox vaccination. In conjunction, inventory of the vaccine was decreased to save money. The virus was locked up in two labs, one in the United States and one in Russia. However, some feel the smallpox virus exists elsewhere. Dr. Peter Jahrling and a team of scientists at the U.S. Army Medical Research Institute of Infectious Diseases in Maryland became concerned terrorists had access to the smallpox virus and planed to alter the strain to become more resistant. These doctors conducted smallpox experiments to discover more effective vaccines in case the virus were released. Preparedness for a major epidemic is discussed as well as the ease with which smallpox can be bioengineered.
Guillemin, J. (2005). Biological weapons: From the invention of state-sponsored programs to contemporary bioterrorism Columbia University Press.
Blackbird's book, like many similar autoethnographic texts, is a combination of autobiography, history, ethnography, and polemic. He opens with a conventional reference to inaccuracy in current histories. In the course of correcting the record he relates the story, preserved by elders of his nation, of a smallpox epidemic during the height of the French and Indian War, about 1757. Blackbird's story is unique because of the unusual disease vector.
One similarity between smallpox and the black death was that they both established new trade with countries they had rarely traded with before. With smallpox, the Americas were faced with a labour shortage due to the amount of people smallpox had killed. The labour was needed to work in silver mines and sugar plantations.To fill the shortage of labour, slaves were traded from the Guinea Coast, somewhere there was not much trade in before, but now was a bustling center of trade due to the demand for slaves. Similarly, during the black death, there was a shortage of people because of the shrunken population. There were less people buying wool, wine, and cheese, so merchants from Europe sook out customers in different areas. Some such areas were
The World Health Organization announced that smallpox had been eradicated from the planet on May 8, 1980. This was prompted by a three year absence of a smallpox infection; the last occurring case was reported in Somalia in 1977. Since then, worldwide stock of smallpox vaccines has been reduced enormously simply because of speculation that there is no need for it anymore and administering the vaccine is impertinent. After the disappearance of smallpox as an afflicting disease, it now exists in labs in only two locations, the United States and Russia, where it is studied for research purposes only. Smallpox is a virus that has two major forms, Variola major and Variola minor, and each form has similar and differentiating symptoms with regards to the other type (Alibek, 1999).
The perspective the author gives to this book is a unique. Smallpox according to most histories does not play the role of a major character, but a minor part. In my opinion smallpox was a major factor during the Revolutionary War, and Feen focuses on several key areas which allows us to see just how bad this epidemic was and the grip it had not only on the soldiers, but the colonist as well.
The original New England Natives first felt the effects of Smallpox and other diseases during the first decade of the sixteenth century. This was shortly after John Cabot explored the coast in 1498. By 1504, constant fishing trips were being made by the French and Portuguese, which started the spread of disease. However, It wasn’t until the outbreak of 1616 and 1617, when huge numbers of natives were killed. Diseases like chicken Pox, cholera, the plague, tuberculosis, and many others were introduced to New England for the first time. For the most part, Europeans had become immune to these diseases over the years. The natives, on the other hand, were completely vulnerable.¹
In order to understand the history of smallpox one first has to understand how diseases like it evolve. Much like other species, diseases that survive in the long run are the microbes that most effectively reproduce and are able to find suitable places to live. For a microbe to effectively reproduce, it must "be defined mathematically as the number of new infected per each original patient." This number will largely depend on how long each victim is able to spread the virus to other victims (Diamond, 198).
By preserving the virus, Boylston personally inoculated 247 people in 1721 and 1722 to prevent transmission. However, from there only six people died, and Boylston was the first American surgeon to inoculate his patients personally. The author portrays the background data Boylston used to examine the inoculation practice on different age and gender of persons to treat his patients from previous experiments. The inoculation method provided higher level of immunity in preventing smallpox infection. The prevention of smallpox is through inducing antibodies through vaccines which last longer for a person taking it.
It is hard to say whether this plan, had it been successful, would have been for the public good. Before this vaccination period, smallpox had been declared eradicated, and only the United States and Russia were allowed to remain in possession of strains of the disease for research. Fearing an attack, President Bush chose to target those who would be the first-responders in the face of a national medical emergency. However, the CDC has emphasized that there is no imminent threat of an outbreak, which leads one to wonder if this vaccine is really necessary or useful to the public, or if it only hinders our workforce and wastes the tax-payer’s money (5).
Smallpox is an very contagious disease that lasts for about 41 days, 24 of those days are mildly to severely contagious. Variola passes from person to person through contact, prolonged face to face contact, contact with body fluids or scabs from pustules, and in extreme cases the pathogen can become an airborne pathogen. The smallpox virus is passed from human to human and it is not known if any other animals and/or insects can directly pass the variola virus to humans. There have been many cases where people have confused the variola virus with other viruses. For example S Scar Rickettsiella is an deadly disease that is nearly identical to smallpox but it is not as deadly and somewhere on the body a little scar shaped like a S (about the size of an mole) appears on the body. There is one live culture of smallpox kept in America in Atlanta, Georgia in an very secure facility. There is also one kept in Novosibirsk, Russia. Many world leaders fear that the next weapon will be biochemical terrorism. Smallpox can become an airborne pathogen which could cause the greatest amount of damage in a terror attack. From the time the virus enters into...
The history of smallpox goes back for thousands of years. It is thought to have appeared as much as 10,000 years ago and since then, it has claimed the lives of millions of people, many of whom have been famous figures in history. After a vaccine was discovered in 1796, countries throughout the world began the fight to eradicate the disease. This fight was won in 1980 as a result of the international effort headed by the World Health Organization. Today, smallpox is no longer a threat in nature but the virus is still stored in labs, from which a biological weapon could be made.