Cancer can develop anywhere in the body. Cells grow abnormally and become cancerous because of environmental factors, such as smoking cigarettes and exposure to radiation; genetics, poor diet, lack of physical activity, and even just luck (Stern et al., 2004). Even though genetics play the primary role in the development of cancer, the environment in which one lives also contributes to the chances of getting cancer. Some of the environmental factors that influence the development of cancer include alcohol use, obesity, asbestos, HIV, and Down’s syndrome.
Cancer has become leading cause of death across world in the class of non-communicable diseases. This has led to massive research in cancer diagnosis and prognosis. Diagnosis of cancer in early stages could prevent its spread to other organs of the body and possible cure of the patient. More and more different types of cancers are being identified and mostly they have to be treated differently. Cancer classification plays a very important role in cancer diagnosis. Earlier strategies used for cancer classification: morphological and clinical had some limitations. They were not able to predict cancer subtypes accurately. It has been identified that giving treatment according to the tumor type is more effective for the patients. Tumors of a particular type of cancer differ at the molecular level, i.e. the genetic level.
Cancer Chemotherapy and Personalized Medicine Cancer is a leading cause of mortality worldwide. It is known to promote the harboring of accumulated genetic alterations in normal host cells, which then promote cancerous growth. Cancer chemotherapy attempts to eradicate or functionally disable tumor cells by the use of synthetic and/or natural compounds while preserving normal cells. Chemotherapeutic agents can eliminate tumor cells by direct cytotoxicity, activating host immune response, inhibiting the proliferation processes of tumor cells and inducing apoptosis.
Leukemia What is Leukemia? Leukemia is a cancer of the white blood cells. It begins in the bone marrow, the soft tissue inside the bones. Within the bone marrow is where white blood cells are created, that help fight off bacteria, viruses, and other microorganisms within the body that cause infections.
The emphasis on health and fitness has become paramount in our society today in an effort to prevent and combat diseases such as Cancers. Cancers are a group of over 100 diseases that affects every aspect of the human system from skin, to bones, to muscles, to blood. One of the most common blood disorders is Leukemia. As defined by the U.S. National Library of Medicine, Leukemia is a type of blood cancer that begins in the bone marrow. The bone marrow is the soft tissue in the center of the bone that is responsible for the production of blood cells. The term leukemia means white blood. The term leukocytes refer to white blood cells, which are body’s defense against infections and other foreign substances. When Leukemia occurs there is an uncontrolled increase in the number of white blood cells. When this occurs, these cancerous cells inhibit the production of healthy red blood cells, platelets, and mature white blood cells. Over time the cancerous cells can spread to the bloodstream and lymph nodes. They can also travel to the Central Nervous System and the rest of the body.
“The word 'leukemia' is a very frightening word. In many instances, it's a killer and it's something that you have to deal with in a very serious and determined way if you're going to beat it” - Kareem Abdul-Jabbar. Many people, including tons of children, fight leukemia every day trying to beat this vicious cancer. Without knowing how leukemia is exactly caused, it puts a damper on how to avoid it.
Niall Killian Killian 1 Samson 6 Leukemia Leukemia is cancer of the blood cells; it starts in the bone marrow which is the soft tissue inside most bones where blood cells are made. When you are healthy your bone marrow makes red and white blood cells. Red and white blood cells help your body fight infection and carry oxygen to all parts of your body. When you have leukemia, the bone marrow makes a unusual amount of abnormal white blood cells known as leukemia cells. Leukemia cells don't work like normal white blood cells, they grow faster and they don't stop growing when they should.
Acute Myeloid Leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous disease which results from genetic alterations in normal hematopoietic stem cells. These alterations induce differentiation arrest and/or excessive proliferation of abnormal leukemic cells or blasts . Recent genomic studies have identified that recurrent somatic mutations in patients with AML blocks differentiation and/or enhance self-renewal by altered transcription factors [2,3]. The genetic or the epigenetic changes acquired by AML cells disrupt the key growth regulatory pathways and changes will make the normal cells to attain certain malignant characteristics which include inappropriate proliferation in the absence of normal growth signals, indefinite self-renewal in a manner analogous to a stem cell, escape from programmed cell death, inhibition of differentiation, aberrant cell cycle checkpoint control and genomic instability .
This disease diary is about leukemia. Leukemia is when certain abnormalities cause the cell to grow and divide more rapidly and to continue living when normal cells would die. Over time the abnormal cells can gather around healthy blood cells in the bone marrow, leading up to fewer healthy white blood cells, red blood cells, and platelets, and causing the signs and symptoms of leukemia. Scientists don’t understand the exact cause of leukemia, but they think it seems to develop from a combination of genetic and environmental factors. Doctors classify leukemia on the speed of progression and the types of cells involved. Acute and chronic leukemia are the first type of classification where it depends on the speed, and lymphocytic and myelogenous