Beta 1 Integrins

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Recommended: Cell migration mechanism

A mammal’s cell migrates by having their actin filaments polymerize, or build up, that causes a part of the cell membrane to extend out. This part is called the leading edge. The leading edge attaches to the extracellular membrane (ECM) in order to pull itself forward in order to travel. Actin binding proteins regulate position, speed, and persistence of the leading edges.
The objective of this research was to figure out if leading edges of migratory cells work together with adhesion receptors to cause cell migration though the ECM.
The scientists hypothesized that the leading edges of migratory cells search for places in the ECM to adhere to.
The scientists observed the small ripples on the cell membranes under a high-contrast differential interference contrast, which is a type of microscope that is good to use for observing cells. …show more content…

Using a fluoresced antibody, the scientists observed the clustering of beta 1 integrins that occurred at the same time as actin polymerization at the ripples of the cell membrane.
The scientists tested the relationship between actin polymerization and activated beta 1 integrins by changing the way that the actin worked. They decreased the number of polymerizing actin ends by capping with with cytochalasin D in order to see if that would cause the amount of activated beta 1 integrins to decrease. They also increased the actin polymerizing ends with the stabilizer, jasplakinolide in order to see if that would cause the amount of activated beta 1 integrins to

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