Effect of the administration of etoricoxib using nanotechnology for the treatment of experimental arthritis in a mouse model
Inflammation is a basic yetcomplex process that protects the body by eliminating both the causes and consequences of injury, such as microbes, toxins, and necrotic cells. Therefore, plasma proteins, circulating cells, and tissue phagocytes(the body’s defenders against foreign invaders) must be recruited to the extravascular space in order to rid the organism of these factors(Kumar et al.,2010). Recent advances in nanomedical research have provided scientists with nanocarrierswithmany unique and tunable properties to match the specific requirements for the treatment of variousinflammatory diseases.
Etoricoxib is a non-steroidal anti-inflammatory drug that selectively inhibits isoform 2 of the enzyme cyclooxygenase(cox-2). The drugis approved for use in more than 70 countries worldwide for the treatment of rheumatoid arthritis, psoriatic arthritis, and osteoarthritis. Although it is available for the treatment of many inflammatory conditions, its low bioavailability and nontargetedbiodistribution often limit its success in controlling disease symptoms.
Neutral nanoparticles with sizes smaller than that of the vascular-pore cutoff are likely to escape surface opsonization and will have significantly low uptake by the reticuloendothelial system. These particles will circulate longer in the blood and can be passively targeted to inflamed tissues. On the other hand, particles intended for uptake by macrophages should be larger and contain distinct surface charges to facilitate their interaction and internalization by macrophages (Moghimi et al., 2001). Therefore, nanoencapsulation of etori...
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...ng the General Linear Model procedure inSPSS (2004).
5: Utilization/Contribution of Research
Results in addressing development issues in the Kingdom of Saudi Arabia
Arthritis is a widespread, chronic inflammatory disease involving damage to the joints of the body. Rheumatoid arthritis, the most common form of inflammatory arthritis, isa destructive joint disease that may affect 0.5-1% of the population in the industrialized world, leading to significant disability and a reduction in quality of life (Lee and Weinblatt, 2001; Smolen and Steiner, 2003). The results of this research will provide a means of improving the treatment of rheumatoid arthritis by saving the time and effort involved with suboptimal treatment, and as such the investigations proposed here will result in increased overall productivity of the population ofthe Kingdom of Saudi Arabia.
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