Hemophilia
What is hemophilia?
Hemophilia is a inherited disease. It’s when there is either exaggerated blood clotting, or poor blood clotting. Blood clotting is when blood changes from a liquid state to a solid state. so it’s like if you cut yourself and it takes a longer time than it should for it to stop bleeding, it doesn’t bleed faster, just longer. It’s a lifelong disease, and people can live normally if they have it. It is very rare 1 in 10,00 people have it. And it is when people don’t have enough clotting factor, clotting factor is the proteins that control the blood. The major types of these conditions is hemophilia A, internal bleeding and bleeding into joints, and hemophilia B, they go through bleeding issues through childhood and a little through puberty. both of them are very similar but are caused by different substances in the genes. We use roman numerals from I to XII to number all the twelve clotting factors having too little of factors VIII or IX is what causes hemophilia a person with hemophilia will only lack one of these two types, but never both. 80% of hemophilia victims are hemophilia A VII, hemophilia B is when IX is lacking.
What are the causes of hemophilia?
Hemophilia caused by genetic mutation. The mutation involve genes that code for proteins that are in the blood clotting , the bleeding symptoms rise because blood clotting is repaired. For blood clotting to take place, we need damaged tissue. Then it activates platelets, then releases calcium ions, and the prothrobin (proteins found in the plasma, with the thrombin and calcium ions, it’s converted to thrombin. Fibrinogen (another protein found and the thrombin and calcium ions to fibrin, blood clot). Fibrinogen is a soluble protein, but ...
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...ent bleeding episodes, and subsequent complications, such as joint and/or muscle damage. More commonly used for patients with moderate or severe hemophilia.
Infusion of clotting factor taken from donated blood.
What are social and economic impacts of hemophilia?
You have hemophilia, you could live a normal life, travel, leave home, go to work, and enjoy themselves, but they just have to watch out, they can’t cut themselves or else they will suffer from bloodless, because the hemophilia and lack of blood clotting factors, so they have to bring with them, a vaccine or something to increase the amount of blood clotting factors that they have a loss of. This mainly counts on its severity. Me may die from sever blood loss. And some may have major bleeding events. The people with hemophilia can live a normal life, but they can’t pretend like they don’t have it.
Symptoms and Causes Thrombocytopenia leads to excessive or unexplained bruising, nose bleeds, and severe bleeding that does not stop immediately. This can cause internal bleeding and extends to severe brain bleeds.... ... middle of paper ... ... 2. 2-3 Cohen, R., Garcia, C.A., Mena, D., Castellanos, M., Wu, L.T. April 2012 -. “Case Review: Idiopathic Thrombocytopenia Purpura.”
○ ABO incompatibility. People with an O blood type have antibodies that can attack blood cells in type A or B blood. If a mother 's blood type is O and her baby 's blood type is A or B, her antibodies may destroy the baby 's red blood cells and cause hemolytic disease.
Hemophilia is a genetic bleeding disorder. People who have hemophilia have a deficiency or an absence of a coagulation protein. A blood clotting factor is deficient or absent. Bleeding is most often in joints, such as the knee, elbow, or ankle, but bleeding can occur anywhere in the body. People with hemophilia bleed longer, not faster.
Hemophilia is a rare bleeding disorder that slows the blood clotting process, which is not normal. Some people with Hemophilia may just have a little bit of “clotting factor” or no clotting factor at all (National Institute of Health [NIH], 2013). Clotting factor is a protein in blood that controls bleeding and they are needed the blood to clot normally. In order to help the blood clot, clotting factors work with “platelets” (National Institute of Health [NIH], 2013). Platelets are small blood cell fragments that form in the bone marrow, a tissue in the bones that is similar to a sponge. The functions of platelets have a very important role in blood clotting; the role of a platelet is to stick together (by the help of clotting factors) to block cuts, break on the carriers of blood (veins or arteries) throughout the body, and stop the bleeding when “blood vessels” (National Institutes of Health [NIH], 2013) are injured. Blood vessels are tube like structures carrying blood through the tissues and organs, like a vein, artery, or capillary. People with hemophilia do not have enough “clotting factor VIII or IX” (World Federation of Hemophilia [WFH], 2013) in their blood, which results to prolonged bleeding or oozing, meaning that bleeding can last longer (though, not faster) than usual after surgeries, accidents, or having teeth pulled out at the dentist. Clotting factor VIII, which can also be called as “anti-hemophilic factor” (AHF, for short) (Patient.co.uk, 2011), is a blood clotting protein that is necessary for humans to have. Clotting Factor IX is a protein that i...
“...an individual with [pedophilia] has the same ingrained attraction that a heterosexual female may feel towards a male, or a homosexual feels towards their same gender.” (Johnston, Pg. 1). Pedophilia - “the fantasy or act of sexual activity with children who are generally age 13 years or younger” (American Psychiatric Association, p.1) - a word that holds multiple negative connotations, is often seen as aberrant thought process or behavior, and is under debate as to whether or not it’s a sexual orientation. But can it be considered a sexual orientation? As a member of the LGBT community, this issue has surfaced among us and shocked the majority.
“And this disease of which I speak, this syphilis too will pass away and die out, but later it will be born again and be seen again by our grandchildren just as in bygone ages we must believe it was observed by our ancestors.” – Fracastoro, 1538 1
Hemophillia is a rare bleeding disorder in which the blood does not clot normally. Hemophillia is usually inherited and people born with it have little or no clotting factor (a protein needed for normal blood clotting). These proteins work together with platelets to help the blood clot. When blood vessels are injured, clotting factors help platelets stick together to plug cuts and breaks on the vessels. Hemophillia usually occurs in males with about 1 in every 5 000 males being born with the disease each year. A hemophiliac does not bleed more intensely than a person without it but can bleed for a much longer time. In some severe cases, continuous bleeding occurs after minor trauma or can even happen spontaneously.They may also bleed inside their body(internally), especially in the knees, ankles, and elbows. The bleeding can damage organs and tissues and may be life threatening. There are two main types of hemophilia: A and B. People born with type A are missing or have low levels of clotting factor VIII (1 in 5 000 males). People born with type B are missing or have low levels of clotting factor IX (1 in 20 000 males). About 8 out of 10 people who have hemophillia have type A. The greatest concern for both types is deep internal bleeding and bleeding into joints. Hemophilia is a life long disease, but with proper treatment and self-care, most people maintain an active productive lifestyle.
Tsar Nicholas II and his Tsarina, Empress Alexandra, had only one son, Tsarevich Alexei. However, Alexei had inherited from his great-grandmother Queen Victoria the life-threatening genetic disease hemophilia B, a sex-linked genetic disease on the X chromosome that caused a condition of deficiency in blood-clotting and excessive bleeding, symptoms that usually remain hidden unless contracted by a male (Fuhrmann 37; King 28). To Nicholas II, it was imperative that he have a son to succeed him to secure the throne. Alexei was Nicholas’s sole male heir, giving Nicholas the incentive to protect his son at all costs. Without a scientific cure for the genetic disease, Alexandra turned to religion, namely Grigori Rasputin, a poor uneducated Siberian peasant to protect her son.
Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of, or are missing, one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor IX is not present in sufficient amounts or is absent. People with hemophilia do not bleed more profusely or bleed faster than normal; they bleed for a longer period of time.
The changes in f8 and f9 gene are responsible for hemophilia A and B. the f8 gene codes for a protein called coagulation 8. This protein is responsible for the blood clotting process. After an injury blood clots protect the body by sealing off the area of injury. Mutation in the f8 and f9 gene can lead to the abnormal form of the protein. Also can lead to a reduction of the coagulation pro...
Paraphilia has evolved as a term generally referenced as sexually deviant behavior to a broader term and divided into a disorder by the DSM-5. Paraphilia’s are often misconstrued as sexually deviant behavior that is misunderstood by the general public. In this paper, I will attempt to have a better grasp of what a paraphilia is, how to treat paraphilia from a therapeutic standpoint and attempt to discern when a paraphilia may need additional referrals and/or treatment. This paper will also examine the difference between a paraphilia that may be treated through cognitive behavioral therapy and paraphilic disorders, in which distress is found and may need further intensive treatment. Cognitive behavioral therapy is one method of psychotherapy
Unlike sex, the history of sexuality is dependant upon society and limited by its language in order to be defined and understood.
What controls a human's sexual orientation? The long-standing debate of nature versus nurture can be extended to explaining human sexual orientation. Is it biological or environmental? The biological explanation has been gaining popularity amongst the scientific community although it is only based on speculations. It is argued that sexual orientation is linked to factors that occur during sexual differentiation. The prenatal exposure to androgens and their affect on the development of the human brain play a pivotal role in sexual orientation (2). Heredity is also part of the debate. Does biology merely provide the slate of neural circuitry upon which sexual orientation is inscribed? Do biological factors directly wire the brain so that it will support a particular orientation? Or do biological factors influence sexual orientation only indirectly?
Rodak, B. F., Fritsma, g. A., & Doig, K. (2007). Hematology: Clinical Principles and applications. St. louis: Saunders Elsevier.
The patient has high temperature-sign of fever, a very fast pulse rate (tachycardia), and chest wheezing when listened to using a stethoscope (Harries, Maher, & Graham, 2004, p.