Pathogenesis Of Ziabetus Shakri (Diabetes Mellitus) In Unani System Of Medicine
In Unani system of medicine, ancient Philosophers explained the pathogenesis of Ziabetus Shakri (Diabetes Mellitus) logically and rationally. The mainstay of Ziabetus is the development of abnormal hot temperament in the kidney. This altered hot temperament renders the renal vessels paralyzed and hence dilated. The morbid hot temperament disturbs the normal functioning of kidney and reduces the Quwwate Masika (Retentive power) of kidney. In contrast to the reduced retentive power, the morbid hot temperament, on the other hand increases the Quwwate Jazba (Absorptive power) of kidney. The excessive thrust of Quwwate Jazba pulls and absorbs the excessively large amount of water from the liver but as unable to digest and retain the fluid due to weak Quwwate Masika and strengthen Quwwate Dafia, the fluid ultimately passes out towards the urinary bladder and finally in the form of urine large amount of fluid excreted. The deficit of fluid thus created in the liver is compensated by excessive absorption of fluid from the Urooqe Masariqa (Mesenteric vessels). The Urooqe Masariqa absorbs the fluid from
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After insulin has bound to and activated its receptor “second messengers” are generated which initiate a series of events that eventually result in the stimulation of intracellular glucose metabolism under the control of insulin (121, 162, 163, 164, 165, 166, 167, 168). In Type-2 Diabetes Mellitus insulin binding to target tissue is reduced due to decreased number of receptors without change in insulin receptor affinity. In addition to the decreased number of cell surface receptors, a variety of defects in insulin receptor internalization and processing also occurred.
With Egyptian woman being of one aspect of a multi-dimensional look at woman of the ancient times, woman who wrote classical literature in India also played an important part in providing future generations with stories and poems that were skillfully explained with suggestions, compared to the graphic descriptions that were seen in Ancient Egyptian love poems. One of the ancient Indian authors who perfected this technique is Vikatanitamba. Even though Vikatanitamba is similar in evoking passion within her poems, like the ancient Egyptians, she shows her able show her multi-dimensionality, but discretely. One poem where this was skill was shown was “As he came to bed”. Within the first line, she is able to subtly explain her dress falling off
The kidneys play a major role in the blood composition and volume , the excretion of metabolic wastes in the urine, the control the acid/base balance in the body and the hormone production for maintaining hemostasis. The damages to the GBM in the glomeruli alter filtration process that allows the protein and red blood cells to leak into the urine. Loss of protein like albumin in the urine results in a decrease of their level into the blood stream. Consequently, this patient’s blood reveals a decreased albumin (Alb) value of 2.9 g/dL, decreased serum total protein value of 5 .0 g/dL and in the urine presents of the protein and the RBCs. Impaired filtering capacity result in inability of kidneys to excrete excretory products like electrolytes and metabolic waste products that will then accumulate in the blood. Furthermore, inability of distal convoluted tubules to excrete sufficient quantities of potassium, sodium, magnesium (Mg), chloride (Cl), urea, creatinine (Cr), alkaline phosphatase (Alk Phos), and phosphate (PO4) results in their elevation in the blood. His laboratory values reveal an increased of sodium value of 149 meq/L, an increase of potassium value of 5.4meq/L, increased chloride value of 116 meq/L, increased blood urea nitrogen (BUN) serum of 143 mg/dL, and increased creatinine serum of 7.14 mg/dL. The other abnormal blood tests associated with a loss of kidneys’ filtration property identify in this patient are related to an increase of alkaline phosphatase value of 178 IU/L, increased magnesium value of 3.8mgdL, and increased phosphate (PO4) value of 5.9 mg/dL .
According to Lewis and associates, DM is a chronic disease that affects multiple body systems. For the purpose of this paper, only DM type 2 will be discussed based on the assumption that a majority of patients aged 60 years or older have this type. The primary defects of this disease consist of insulin resistance, decreased insulin production, inappropriate glucose production by the liver, and alterations in production of adipokines. Insulin resistance is the result of defects in the body’s insulin receptors. This finding predates all cases of DM type 2 and the development of impaired glucose tolerance. In insulin resistance, beta cells in the pancreas are stimulated to increase insulin production to compensate for the lack of response by the insulin receptors. Gradually, the beta cells begin to fail to secrete enough insulin to meet the body’s demands resulting in hyperglycemia. As a result of increased glucose in the liver, the liver begins to malfunction and release glucose at inappropriate times, thereby worsening hyperglycemia. Adding to the problem, glucose and fat metabolism is altered in adipose tissue, which is generally abundant in those with DM type 2. (Lewis et al., 2011)
Our body obtains the energy by digesting the carbohydrates into glucose. Volumes of glucose are required by the body to create ATP. ATP is short for 'Adenosine Triphosphate ' and is an energy carrier. When we consume too many carbohydrates our body produces a lot of glucose and as a result blood glucose levels rise and sometimes they may rise over the normal range of blood glucose concentration. To bring it back within the healthy range, the homeostatic system of blood glucose regulation is used. The blood flows through the pancreas where the beta cells, receptors, detect the high blood glucose level. To counteract this stimuli beta cells alert the control centre, which are also the beta cells located in the islets of Langerhans in the pancreas. The secretion of insulin has to be done quickly but can only be carried out when insulin gene is switched on. Turning on the insulin gene switch can take 30 minutes to an hour therefore, the production of insulin by beta cells are done in advance and are packaged in vesicles right until blood glucose rises. Glucose comes into the beta cell to trigger the vesicle that contains the insulin to move towards the plasma membrane and fuse. This releases the insulin into the bloodstream where they are distributed throughout the body and only affect specific target cells. The receptor, a protein, on the target cell’s plasma membrane recognises and connects
The faulty responsiveness of body tissues to insulin normally entails the insulin receptor found in cell membranes. The other type, the gestational diabetes happens in women who have not been diagnosed with diabetes before and show elevated blood glucose amounts during pregnancy. There is no explicit reason that has been acknowledged but it is assumed that the hormones secreted dur...
Diabetes Mellitus is a disease of the endocrine system primarily differentiated between type 1 and type 2. Type 1 diabetes occurs when the pancreas is unable to produce insulin and was previously seen in the younger generation which is no longer the case.1 Type 2 diabetes is the more prevalent of the two types and involves elevated blood sugar levels due to the insufficient production of insulin. Risk factors that make an individual higher risk for type 2 diabetes include increasing age, obesity, family history, a sedentary lifestyle.1,2 Innovative drug therapies for type 2 diabetes remain important for the treatment and reduction of the disease.
Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas plays an important role of the metabolism of glucose by means of secreting the hormones insulin and glucagon. These hormones where then secreted by Islets of Langerhans directly to the blood. Inadequate secretion of insulin results on impaired metabolism of glucose, carbohydrates, proteins and fats which then result to hyperglycemia and glycosuria. Hyperglycemia is the most frequently observed sign of diabetes and is considered the etiologic source of diabetic complications both in the body and in the eye. On the other hand, glucagon is the hormone that opposes the act of insulin. It is secreted when blood glucose levels fall.
“ Each nephron interlinks with a small tube to keep useful substances, such as proteins and red blood cells, in the bloodstream and allow extra fluid and waste products to pass through, where they become part of the urine. This filtration system can, however, be damaged by high levels of blood sugar. Excess glucose in the bloodstream can cause the kidneys to filter too much blood” (“Kidney failure and
Dinoflagellates are one of the four main types of phytoplankton, which are photosynthetic, single celled and free living organisms in the ocean. Dinoflagellates cause the Harmful Algal Blooms (HAB) also known as the red tide effect (Hackett et al 2004). Toxicity persisting at upper levels of the food chain is detected in them from the ones which are toxic, but not all such blooms are toxic. Enhanced detection capabilities may in part contribute to observed high frequency and severity of toxic blooms. As they are also important in the health of coral reefs their study has gained significant interest. Species are often selected for genome sequencing based on their importance as a model organism or relevance to human health, such as the HAB case.
Zechariah Zechariah is one of the Minor Prophets of the Old Testament. His book is located between the books of Haggai and Malachi. Zechariah is thought to have preached from about 520-518 B.C. The book of Zechariah deals with the restoration of Jerusalem, the Temple, and God‘s people. Chapter 11 verses 4-17, which is a story of two shepherds, is one of the most difficult passages in the Old Testament to understand.
Glomerulonephritis is a disease that causes the inflammation of kidneys’ filters. The kidneys’ filters are in charge of remove the waste from the blood, and then excreted it as urine. Even though Glomerulonephritis can be caused by itself, diabetes and lupus can ...
Diabetes mellitus is a group of metabolic disorders which is characterized by hyperglycemia due to insulin deficiency or resistance or both reasons. (1) According to that diabetes mellitus can be divided as type I and type II. This is common and its incidence is rising, 171 million people had diabetes in 2000 it is expected this condition to be doubled in 2030. It is spread in all the countries and therefore has become a major burden upon healthcare facilities. (2)
The kidneys are a bean-shaped organ in the human body and they have different functions and are of vital importance for it. The kidneys are the pair of organs, which are able to regulate the reabsorption of ions such as potassium, sodium and calcium, which are fundamental substances for the cell. Furthermore, they are involved in the reabsorption of nutrients in the bloodstream and they can regulate the acidity of the blood. Besides the regulation of the fluids and ions, the kidneys are also responsible for the regulation of many different hormones that are involved in homeostasis and metabolism. Because of their importance in the regulation of substances in the body, when the kidneys stop working properly all the body is influenced by that creating disequilibrium in the maintenance of homeostasi...
Drug is a chemical which alters the processes in the organism, which is used in the medicine for prevention, diagnosis and treatment of the diseases (Farlex, 2011). Drug discovery is a long term process that needs money investment. The process of drug investigation takes approximately from 9 to 15 years during which the number of chemicals that can become drug is reduced from 10,000 to 1-2 (Saparov, 2011). Even after manufacturing the drug is studied by scientists for modifying its structure, delivery and effects on the organism. Drug discovery consists of several stages which help to examine its effectiveness and side effects.
There are numerous metabolic diseases that affect people all around the world. One of the most common metabolic diseases is diabetes which involves carbohydrate metabolism. Carbohydrate metabolism starts with digestion in the small intestine where simple carbohydrates are absorbed into the blood stream (1). Blood sugar (glucose) concentrations are managed by three hormones: insulin, glucagon, and epinephrine. When glucose concentrations in the blood become elevated, insulin is secreted by the pancreas. Insulin stimulates the transfer of glucose into the cells, especially in the liver and muscle tissue, although other organs are also able to process glucose (2).