Breidenstein, Elena BM, César de la Fuente-Núñez, and Robert EW Hancock. "Pseudomonas aeruginosa: all roads lead to resistance." Trends in microbiology 19.8 (2011): 419-426.
Driscoll, James A., Steven L. Brody, and Marin H. Kollef. "The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections." Drugs67.3 (2007): 351-368. This article discusses how pseudomonas aeruginosa is largely the cause of infection in hospital patients, immunocompromised hosts, and cystic fibrosis patients. It also voices concerns of the antibiotic resistance pseudomonas aeruginosa builds to various antibiotics. Mechanisms of antibiotic resistance involve multidrug efflux pumps, β-lactamases and downregulation of outer membrane porins. Virulence mechanisms
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"The type III secretion system of Pseudomonas aeruginosa: infection by injection." Nature Reviews Microbiology 7.9 (2009): 654-665.
This article explains the type III secretion apparatus of pseudomonas aeruginosa that injects effector proteins into host cells. The effector proteins that are secreted by the type III secretion method begins the process of infection of the pseudomonas aeruginosa bacterium. This type of secretion has specific translocation and regulation of machinery and effector proteins. These are different for each type of secretion. These pseudomonas aeruginosa pathogenesis and secretion systems also have various ramifications that make them
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Cystic Fibrosis patients are predisposed to infections from pseudomonas and have two separate strains of the pathogen. A comparative analysis was performed on the genomes of the two strains to show the blocking of specific gene and are found on few chromosomal positions. This gives pseudomonas aeruginosa a favorable survival ability to change shapes according to its environment. This adaptation influences the bacteria’s genome configuration has a major impact on evolution. This shows pseudomonas’ ability to resist antibiotics and thrive in various environments.
Norman, R. Sean, et al. "Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods." Nano letters 8.1 (2008): 302-306. This article discusses alternative antibiotics for antibiotic resistant bacteria. The author brings up the idea of using a nanotechnology-driven approach to fight against pseudomonas aeruginosa. This would be done by using nanoparticles to target and destroy pathogenic bacteria targeted selectively. This has been explored by using gold nanorods that were previously linked to antibodies that will selectively destroy the pseudomonas aeruginosa bacterium. The results show that the exposure to this type of radiation produces a reduction of the viability of the bacterial cells.
Strateva, Tanya, and Daniel Yordanov. "Pseudomonas aeruginosa–a
Studies have shown pertactin, a 69kDa non fimbrial outer membrane protein, facilitates attachment of the bacteria to ciliated respiratory cells. Experiments conducted on humans to test the role of pertactin have shown no significant effect except with the results from Bassinet (4). Furthermore, filamentous haemagglutinin confers infection by attaching to the host cells in the lower respiratory tract. It is about 2nm wide, and 50n...
Trabelsi, H., Dendana, F., Sellami, A., Sellami, H., Cheikhrouhou, F., Neji, S., … Ayadi, A. (2012). Pathogenic
However, increasing antibiotic resistance patterns among intensive care unit pathogens, cultivated by empiric-broad spectrum antibiotic regimens, characterizes the variable concerns. Recent literature point that antibiotic use before the development of VAP is associated with increased risk for potentially resistant gran-negative infections and Methcillin-resistant Staphylococcus auereus (MRSA)
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
Clinical Infectious Diseases, 49(3), 438-443. Doi:10.1086/600391. See full address and map. Medicare.gov/Hospital Compare - The Official U.S. Government Site for Medicare (n.d).
Cystic Fibrosis is an inherited disease characterized by the buildup of thick, sticky mucous that can cause severe damage to the body’s organs. Mucous is usually a slippery substance that lubricates and protects the linings of the airway, digestive system, reproductive system and other organs and tissue. Problems with digestion can lead to diarrhea, malnutrition, poor growth, and weight-loss. Due to the abnormally thick mucous it can can clog airways, leading to breathing problems and bacterial infections in the lungs. Bacterial infections can lead to coughing, wheezing and inflammation. Overtime these infections can lead to permanent damage in the lungs including the formation of scar tissue, known as fibrosis and cysts in the lungs (Genetics Home Reference, 2013). The symptoms and signs of this disease vary but mostly include progressive damage to the respiratory system and chronic digestive system problems. An individuals’ lungs who are infected by cystic fibrosis have bacteria from an early stage. This bacteria can spread to the small airways, leading to the formation of bacterial micro-environments known as biofilms. Biofilms are difficult for antibodies to penetrate, therefore the bacteria repeatedly damage the lung and gradually remodel the airways, resulting in difficultly to eradicate the infection (Welsh, 1995). Cystic fibrosis patients may even have their airways chronically colonized be filamentous fungi and/or yeasts. Most men with cystic fibrosis have congenital bilateral absence of the vas deferens (CBAVD), a condition in which the tubes that carry sperm are blocked by mucous and do not develop properly. As well, women may experience complications in pregnancy. Either the c...
For CSF, 6 of 62 MS patients, and 1 of 40 controls, were positive for ETX immunoreactivity. For the analysis of sera, 6 of 56 MS patients, and 0 of 60 controls were seroreactive to ETX.
Slack, John M. and I. S. Snyder. Bacteria and Human Disease. Chicago: Year Book Medical Publishers, Inc., 1978.
Infectious diseases are the disorders caused by organisms such as bacteria, viruses, fungi or parasite who live both inside and outside our bodies and are normally helpful but can cause infectious diseases to the human (body) system under certain conditions. And for a disease to be infectious, there is what is called ‘’chain of infection’’ that takes place before. And this can be seen in the below diagram:
Streptococcus pneumoniae is a Gram-positive and fast-growing bacteria which inhabit upper respiratory tract in humans. Moreover, it is an aerotolerant anaerobe and usually causes respiratory diseases including pneumonia, otitis media, meningitis, peritonitis, paranasal sinusitis, septic arthritis, and osteomyelitis (Todar, 2003). According to Tettelin et al., more than 3 million of children die from meningitis or pneumonia worldwide (2001). S.pneumoniae has an enzyme known as autolysin that is responsible for disintegration and disruption of epithelial cells. Furthermore, S.pneumoniae has many essential virulence factors like capsule which is made up of polysaccharides that avoids complement C3b opsonization of cells by phagocytes. Many vaccines contain different capsular antigens which were isolated from various strains (Todar, 2003). There are plenty of S.pneumoniae strains that developed resistance to most popular antibiotics like macrolides, fluoroquinolones, and penicillin since 1990 (Tettelin et al., 2001). Antibiotic resistance was developed by the gene mutation and selection processes that, as a consequence, lead to the formation of penicillin-binding proteins, etc. (Todar, 2003).
For many years we have become increasingly dependant on antibiotics to fight off the bacteria that cause diseases in our bodies. Many of the diseases these bacteria and microbes cause are infectious. For these reasons, it has been noticed that bacteria and other microbes are becoming increasingly resistant to the antibiotics prescribed to sick people. Many doctors prescribe antibiotics for common illnesses, yet other medicines such as home remedies and homeopathy could be used instead. As a result, we are using antibiotics too often, as many sources claim we should only be using them once every three years.”Bacteria have shown a remarkable ability to endure and adapt to their environment including the development of different mechanisms of resistance to most old and new antimicrobial agents”. Because of the frequent prescription, the bacteria and microbes that cause these illnesses are exposed to the same type of antibiotics frequently, thus they are able to adapt and build up resilience against these antibiotics. “Bacteria have developed resistance to all different classes of antibiotics discovered to date” . This is a major problem as we rely so heavily on antibiotics to treat serious illnesses that we are running out of options to treat them with. The prescribing of antibiotics for illnesses that are not life-threatening are now resulting in fewer solutions to cure people affected by diseases that can be fatal.
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
Emerging Infectious Diseases (EIDS) are a disease of infectious origin whose incidence in humans has increased within the recent past threatens to increase in the near future. Over 30 new infectious agents have been detected worldwide in the last three decades; 60% of these are of zoonotic origin, and more than 2-3rds of these have originated in the wildlife (Dikid et al., 2013).
Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die. On the other hand, cells that have some resistance from the start or acquire it later may survive. At the same time, when antibiotics attack disease-causing bacteria, they also attack benign bacteria. This process eliminates drug-susceptible bacteria and favors bacteria that are resistant. Two things happen, populations of non-resistant and harmless bacteria are diminished, and because of the reduction of competition from these harmless and/or susceptible bacteria, resistant forms of disease-causing bacteria proliferate. As the resistant forms of the bacteria proliferate, there is more opportunity for genetic or chromosomal mutation (spontaneous DNA mutation (1)) or transformation, that comes about either through a form of microbial sex (1) or through the transference of plasmids, small circles of DNA (1), which allow bacteria to interchange genes with ease. Sometimes genes can also be t...
The most effective way to combat pathogenic bacteria which invade the body is the use of antibiotics. Overexposure to antibiotics can easily lead to resistant strains of bacteria. Resistance is dangerous because bacteria can easily spread from person to person. Simple methods for preventing excessive bacterial spread are often overlooked. Not all preventative measures are even adequate. Doctors and patients often use antibiotics unnecessarily or incorrectly, leading to greater resistance. Antibiotics are used heavily in livestock and this excessive antibiotic use can create resistant bacteria and transfer them to humans. In order to reduce resistant bacteria,