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War influence on the development of penicillin
Alexander Fleming's words when he invented penicillin
The Discovery of Antibiotics
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PENICILLIN: THE WONDER DRUG
There are many different forms of antiseptics in the world today. One of the first effective antiseptic was penicillin. Penicillin was discovered in 1929 by Alexander Fleming. It was a complete accident. Penicillin became a very important drug during World War II. The importance of penicillin was not directly seen as it took years before a usable form would be developed. Penicillin, despite the setbacks, has led to many new discoveries. Manufacturing problems and disinterest after discovery plagued penicillin, and yet the newly discovered drug would do wonders for people. The story of the discovery of penicillin is well known. Alexander Fleming was conducting an experiment on a bacteria
Florey traveled with Heatley to the U.S. In the United States, Reid and others were already conducting their own experiments on penicillin. Florey and Heatley were directed to Charles Thom. Heatley teaches Thom how he developed a method to create a usable form of penicillin. However, he was missing a key ingredient but Thom suggested the use of a corn liquor. This corn liquor produced more penicillin than Heatley’s solution did. The manufacturing problem was solved just in time for a fire in Boston in 1942 that left many burned and some dead. The burned developed infections and were treated with penicillin. This was the first major large scale treatment with penicillin and it was a success. The burn victims became better. Shortly after this fire, the U.S. entered into WWII. The government took control of the production of penicillin. In the war, penicillin truly shined. Wounds that were infected were treated with penicillin. Many lives were saved. Lives that would have been lost due to infection were saved due to the penicillin’s ability to stop bacterial
There were people upset with Fleming receiving it but he does deserve credit. He discovered the strain of penicillin mold in which penicillin resided. The specific compounds in his mold were only found in two other samples. One was from Fleming himself and the other was on a rotting cantaloupe. The odds that the penicillin was discovered were very slim. He is also the first man to apply penicillin to an infection. His friend had an infection is his eye and was to participate in a shooting contest on a certain weekend. Fleming had no way of treating him other than use the penicillin broth. After Fleming administered the penicillin to his friend, the infection in the eye began to reduce. In a few days it was gone. Fleming recognized that penicillin was a powerful antiseptic as well. The reason many believed that he didn’t deserve it was that he was not responsible for the development of the stable concentration. While he was not part of process, he provided the groundwork and research necessary to create a concentration. He did have a hand in the development even if it was
The Factor of War in the Development of Penicillin The discovery, development and subsequent use of penicillin can be considered to be one of the most important breakthroughs in medical history. There were many factors, which were involved in the development of penicillin, and it could be argued that war was the most important, but other factors were also responsible. Alexander Fleming was working in London as a bacteriologist in 1928 when he noticed that a growth of a mould called penicillin produced a substance that actually killed the germs he was working on. He realised that this might be very important and a year later he wrote an article about his findings. However, Fleming did not have the facilities or the support to develop and test his idea that penicillin could fight infection, and he didn't develop it further.
Years later other scientists were also intrigued by the possibilities of penicillin and produced enough penicillin to prove that it was a useable antibiotic. The scientists from Great Britain were developing all of this during World War II, and unfortunately funding for their drug was unavailable due to the war. They decided to bring their concepts to the United States, and once enough was made, it was eventually used, to treat wounded soldiers during World War I.
Tuberculosis or TB is an airborn infection caused by inhaled droplets that contain mycobacterium tuberculosis. When infected, the body will initiate a cell-mediated hypersensitivity response which leads to formation of lesion or cavity and positive reaction to tuberculin skin test (Kaufman, 2011). People who have been infected with mycobacteria will have a positive skin test, but only ones who have active TB will show signs and symtoms. Basic signs and symptoms include low grade fever, cough with hemoptysis, and tachypnea. They may also show pleuristic chest pain, dyspnea, progressive weight loss, fatigue and malaise (Porth, 2011).
No matter what, where, or who you are, water is a necessary component to keeping any organism alive. Although water is essential for life, in many places, clean drinking water is hard to find. There are many consequences to drinking contaminated water. Every year, three to five million people are attacked by water-borne diseases and over 100,000 of them die. One fatal disease that can kill within hours is cholera.
Acid is produced naturally in your stomach to help you digest food and to kill bacteria. This acid irritates the stomach lining so our body produces a natural mucus barrier which protects it. Sometimes this barrier may be damaged thus allowing the acid to damage the stomach causing inflammation, ulcers and other conditions. Other times, there may be a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed and this allows the acid to escape and irritate the oesophagus. This is called 'acid reflux' and can cause heartburn and/or oesophagitis. Proton pump inhibitors such as omeprazole stop cells in the lining of the stomach from producing too much acid. This can help prevent ulcers from forming or assist the healing process. By decreasing the amount of acid, they can also help to reduce acid reflux related symptoms such as heartburn.
18). Even though those diseases were not his goal to cure it still made penicillin revolutionary for the time being. Fleming now knew how to make penicillin and started to mass produce it. In the 1930s during the upgrading process of penicillin Fleming himself was cured of severe conjunctivitis. Then in the 1940s the fully developed penicillin was created. The creation of penicillin cured a wide variety of diseases, which led to the world excelling in growth, and penicillin improved the way of medicine at the time. The variety of diseases cured by penicillin made it a must have antibiotic. Penicillin was used to cure multiple diseases including syphilis, gonorrhea, tuberculosis, gangrene, pneumonia, diphtheria, and scarlet fever ( Common Antibiotics ). All the diseases have one thing in common, they all have the ability to spread, some faster than others. When a disease is discovered people tried to make a cure. When penicillin was made diseases that were thought to never have a cure were cured. People began to demand that penicillin be sold in local pharmacies. Penicillin was released to help people with the variety of diseases curable by
Ernest Chain and Howard Florey with the knowledge of Flemings work were able to successfully purify an extract of penicillin for testing. The tested it in 1940 on mice, they concluded that those who were given the penicillin lived whereas the others did not. Later in 1945 all three men received the Nobel Prize for their contr...
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
A remarkable breakthrough in medicine occurred in the late 1800s through the work of Louis Pasteur. Pasteur's experiments showed that bacteria reproduce like other living things and travel from place to place. Using the results of his findings, he developed pasteurization, which is the process of heating liquids to kill bacteria and prevent fermentation. He also produced an anthrax vaccine as well as a way to weaken the rabies virus. After studying Pasteur's work, Joseph Lister developed antisepsis, which is the process of killing disease-causing germs. In 1865 before an operation, he cleansed a leg wound first with carbolic acid, and performed the surgery with sterilized (by heat) instruments. The wound healed, and the patient survived. Prior to surgery, the patient would've needed an amputation. However, by incorporating these antiseptic procedures in all of his surgeries, he decreased postoperative deaths. The use of antiseptics eventually helped reduce bacterial infection not only in surgery but also in childbirth and in the treatment of battle wounds. Another man that made discoveries that reinforced those of Pasteur's was Robert Koch. Robert Koch isolated the germ that causes tuberculosis, identified the germ responsible for Asiatic cholera, and developed sanitary measures to prevent disease. (1)
As an undergraduate student the one word that you don’t want to hear from the doctors during a check-up or from a significant other is the word “syphilis”. This is like social suicide in addition to the obvious health issues and pictures that come to mind when hearing about this STD. A term that we have come to hear and to an extent be frightened of ever since that one crazy sex-education teacher ,back in high school, told you it was basically a death sentence if you were to catch it. Now though it’s not necessarily a death sentence it definitely is not your average chicken pox. So what exactly does this have to do with pathology? Everything! Now let’s take a moment to mentally go back in time to the earliest record of this disease.
Discovery and Development of Penicillin. (2014, April 4). Retrieved from American Chemical Society International Historic Chemical Landmarks: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
At his Nobel Peace Prize speech in 1945, Alexander Fleming warned against the misuse of antibiotics and the fact that by doing this, one allows the bacteria to ‘become educated’ and therefore become resistant to the antibiotic. It is believed that the first cases of antibiotic resistance were shortly after this speech. (Fleming, 1945)
Syphilis is a sexually transmitting infection caused by Treonema pallidum, a gram negative, and anaerobic spirochete bacteria 1. Syphilis is thought to have been brought to Europe by Columbus and his sailors in the 1500’s 1. The disease is characterized by four different stages with varying symptoms depending on the stage that the disease is in1. Often syphilis is presented with another sexually transmitted infection such as chlamydia. Public education regarding safe sex is important for the prevention of this sexually transmitted infection.