Mentha arvensis (MA) commonaly known as Mint or Pudina, belongs to family Lamiaceae. It is aromatic herb traditionally used as antiseptic, anthelmintic, diuretic, digestive, expectorent and cardio tonic. In current study, in vitro cytotoxic activity of crude whole plant extracts of Mentha arvensis was evaluated by Sulforhodamine B assay on three human cancer cell-lines of different tissues i.e. A-549(lung), MCF-7(breast) and COLO-205 (colon). Methanol extract of Mentha arvensis was observed to be significantly more cytotoxic in dose dependent manner than Petroleum ether extract of Mentha arvensis with IC50 ranging from 120-165 µg/ml for chosen cell lines. Hemolytic activity on human RBCs was also checked. Crude extracts of MA were found to have no hemolytic effect on RBCs suggesting membrane destabilization is not the mechanism of action. Study thus suggests potential anti-tumor activity of Mentha arvensis and need for further study to identify active components and understand their mechanism of actions.
Keywords: Mentha arvensis, Antitumor Drug Screening Assays, A549, MCF-7, COLO-205
Mentha arvensis (Family- Lamiaceae) is erect branched, strongly aromatic herb that stems up to 75 cm long. Leaves are elliptic to oblong-ovate, 5 cm long, short-petioled, toothed margins, rounded or blunt tipped. Plant has hairy lilac to light blue axillary flowers[1]. It is commonly known as ‘Pudina’, ‘Mint’, ‘Wild mint’ or ‘Corn mint’. Though mainly found in western Himalayas, it is cultivated throughout the India. According to Indian Ayurvedic medicine Mentha arvensis is used as antiseptic, anthelmintic, diuretic, antispasmodic, stimulant, stomachic, carminative, digestive, emmenagogue, expectorent and cardio tonic. It is useful in ulcers, wound...
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...emolytic activity on erythrocytes was also studied for methanol and petroleum ether extracts of Mentha arvensis. Total hemolysis was obtained using 100 μl of sterile D/W after three hours of incubation at room temperature. Test extracts did not possess any hemolytic activity against erythrocytes (Table 2). Lack of hemolytic activity suggests that crude extracts of MA are protecting biological membrane and hence membrane destabilization is not the mechanism of killing cancer cells[17].
Cytotoxic activity of MA oil is already reported on MCF-7 and Lan-CAP cell lines by Husain et al.[18]. Present study reports for the first time in vitro cytotoxic activity of successive methanol extract of MA on cancer cell lines suggesting its potential antitumor activity. Hence further studies are required for identification of active principles and understanding mechanism of action.
The theme of the book as it relates to the American Dream is those who take advantage by becoming covetous and acquisitive. The Clutters in this book are described as the ideal American Dream family. Herb Clutter is the head man of the house who makes sure that his family and financial situations are in order. Herb started off with a struggle but eventually worked hard to become the man he became. Even though they were viewed as a rich family toward the community they did have underlying issues that weren’t visible to the outside world. Dick and Perry on the other hand are those who were unable to achieve the American Dream so they were willing to do anything to become successful the easy way even if that means stealing from others. They
Chemotherapy is the treatment of a tumor with chemical agents to reduce mass or eradicate a tumor completely. There are certain mechanisms by which chemotherapy inhibits cancer. The first mechanism is cell death by cytotoxicity. Some chemical agents in certain amounts are toxic to cells. The cells die due to the toxic...
Wong C. (2014) stated that amla oil helps in strengthen the hair follicles and treating dry and itchy scalp due to its high content of essential fatty acids, vitamin C, flavonoids, polyphenols and other types of minerals. Besides that, the presence of vitamin C in amla gives huge benefits in medical aspects. Vitamin C is known as Ascorbic Acid, ascorbate, Absorbicap, Ascoltin, Cebione Cevalin and Hybrin was discovered in 1928 and most widely used of all vitamins. It is ...
...h an upset stomach, menstrual cramps; I was also told that it would help my sleep at night. Another popular oil is tea tree, I have had personal experiences with this and by putting it on my acne I have seen a dramatic effect with my skin and a reduction of acne. Tea tree oil is also good for burns and ear infections. Peppermint oil is also popular for indigestion as well as mint teas. These each have specific parts of the body that they heal and take affect too.
The crude extract obtained by solvent extraction was subjected to various qualitative tests to detect the presence of common chemical constituents as:
Ramer, Robert , and Burkhard Hinz. "Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1." Oxford Journals | Medicine. N.p., 24 Apr. 2007. Web. 29 July 2013. .
Vinciguerra V, Moore T, Brennan E. Inhalation marijuana as an antiemetic for cancer chemotherapy. New York State Journal of Medicine 1988;88:525-527.
It is known that one of the active constituents of the medicinal plant Couroupita guianensis, namely isatin, is known to exert cytotoxic activity against certain cancer cell lines, being a potential source of new chemotherapeutic agents (Gousia et al., 2013). Isatin is an endogenous compound identified in humans. Biological properties of isatin include the brain and offer protection against certain types of infections. Isatin constitutes an important class of bioactive compounds exhibiting caspase inhibitor, antibacterial and antiproliferative activity (Kiran et al., 2013).
Lindberg, D. (n.d.). Herbal Medicine: MedlinePlus. U.S National Library of Medicine. Retrieved May 7, 2014, from http://www.nlm.nih.gov/medlineplus/herbal
The effectiveness of any plant is not due to the action of any one chemical as modern science would have you believe. When plants are synthesized in a lab, they are analyzed to find their most potent and active components. The rest of the plant is left behind. What science is forgetting is that each leaf, stem, flower and root work in their own unique way to deliver what is need to the body.
The literature review was done to gather the information about leukemia therapy within last five years. The information was extracted via PubMed and James White library by inserting the following key terms: leukemia, treatment of leukemia, leukemia and black seeds, chemotherapy for leukemia, Nigella Sativa, black cumin as anticancer and therapeutic effects of black cumin.
It is easy to find in grocery stores, in the baking aisle, near other flavorings. The scent is strong, compared to other deterrents, peppermint is far more economical. The toxicity studies of the plant have received controversial results. Some authors reported that the plant may induce liver disease, while others found that it protects against liver damage caused by heavy metals. Toxicities of the plant may vary among cultivars and are dose dependent, an effect possibly related to pulegone.
Herbal remedies’ qualities are widespread availability, lower cost, effective for chronic conditions. Herbal remedies are the use of plants or plant extract to treat a person’ overall health. Herbal treatments are prominent for developing countries for instance, “in Africa up to 90% and in India 70% of the population depend on traditional medicine to help meet their health care needs” (Wachtel-Galor & Benzie, 2011), due to their low cost and availability. Herbal remedies have gained attention in the past decades, and expanding their uses due to the increased interest of natural therapies (Wachtel-Galor & Benzie, 2011). Herbs used on the remedies grow in the wild throughout the world, therefore making it easy to
According to Ming-Yeng Pang, a writer of an article Herbal Medicine and Cancer, Considering that herbal medicines are inferiorly regulated than the conventional medicine, manufacturers may differ on the quality and quantity of the medicine. Since there’s no proper and studied techniques on making an herbal remedies, it may cause contamination and dilution. Herbal medicine does interact with pharmaceutical products that it might interfere the effects of the conventional medicine. In relation with this, herbal medicine can be life-menacing (Herbal Medicine and C...
Gingerols, which is the main active component in ginger and responsible for its distinctive taste can also help in inhibiting the growth of cancer cells. In a research made for colorectal cancer, mice were injected cancer cells and only 4 tumors are found in those treated with gingerol c...