Introduction
Vitamin D deficiency has turned into a public health concern in recent years in the United States. With more people likely experiencing vitamin D deficiency or insufficiency due to declining milk intake, increased UV-protective sunscreens, and decreased sun exposure. This is of particular concern for women who are of childbearing age, since many nutrient deficiencies during pregnancy are often associated with adverse outcomes for the mother and the developing fetus.
Vitamin D, which is known as calcitriol in its active form, is vital for calcium homeostasis and a variety of vitamin D dependent gene transcription in humans. Vitamin D deficiency during pregnancy has been linked with altered bone development and rickets (1). In addition, recent findings suggest that vitamin D deficiency could also be associated with asthma and type 1 diabetes (1).
Recent research has investigated the effects of vitamin D supplementation, particularly during pregnancy. However, there still no clear recommendation for vitamin D intake during pregnancy. The current recommended DRI of vitamin D for pregnant women is an adequate intake (AI) of 15 µg/day (400 IU), with an tolerable upper intake level (UL) of 100 µg/day (4000 IU) (2). It is estimated that as high as 41.6% in U.S. adults are vitamin D deficient or insufficient, prompting many to suggest supplementation interventions (3).
There is a greater body of evidence that demonstrates the effects of vitamin D deficiency or insufficiency during pregnancy, yet there is still less known about the consequences of higher vitamin D intake due supplementation. The purpose of this paper is to determine if high dose vitamin D supplementation increases the risk for adverse maternal or fetal outcomes.
Methods
The following methods were used to retrieve the studies that were used in the analysis of the effects of high dose vitamin D
Beginning the case study, we are introduced with the call from the British Medical Research Council (MRC) being informed of the significant results showing the benefits of folic acid and the reductions of NTS’s. The next step for the United States was to decide amongst the CDC and the FDA on the best way to implement these results to women of childbearing age. At that point in time, there were only a few ways to ingest folic acid, which brought
Her findings from this research was praised as she concluded that small supplementary feeding with fruits, milk and wheat germ improved the growth of school children. She also found out that the over dosage of Vitamin D produced brittle bones and calcification of soft tissues. If that wasn’t enough, she continued her extensive research and showed that pantothenic acid is essential for normal pigmentation of hair and skin. Lastly she was intelligent enough to prove that the bone density of woman decreased between 50 and 65 years of
To begin this study there were a total of 349,043 births but due to missing information of supplement use and the amount of multiple births only 280,127 where used for obtaining information. The study was conducted to show any relationship between the use of multivitamin and folic acid with placental abruption. The findings were quite intriguing. Compared with no use, vitamin supplement use was connected with a 26% decreased risk of abruption with the strongest reduction being when folic acid and a multivitamin were used in tandem followed by a multivitamin alone then by folic acid alone. With the data collected it suggest that folic acid and other vitamin use during pregnancy is associated with a reduced risk of placental
Since ancient times vitamin D has been the predominant cause of bone deficiencies.1 However, it was not in till the seventeenth century when both Dr. Daniel Whistler and Professor Francis Glisson made the first scientific description of a vitamin D deficiency.2 During the mid-seventeenth century there was an increase amount of children that were diagnosed with the bone disease called rickets.2 The cause of the rickets was determined to be associated to the lack of sunlight. A German researcher Kurt Huldschinsky came to the conclusion that when infants were exposed to ultraviolet light rays they became cured of rickets2. He stated that a substance in the skin was the potential source of the cure.2 In 1922, American scientist Elmer McCollum proved that when cod liver oil was heated; the beneficial effects of vitamin A in the oil were reduced.2 However, the oil remained effective in curing rickets leading McCollum to reason that a nutrient different from vitamin A was present in the oil. As a result, he named this nutrient vitamin D, which became the fourth vitamin to be discovered and named.2 Additionally, shortly after 1918, vitamin D was also discovered by an accidental experiment that included a group of scientists curing dogs affected with rickets by feeding cod liver oil to them.1
Werler M, Shapiro S, Mitchell A.(1993) Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA. ;269:1257
Other metabolic bone diseases are osteoporosis, gout, OSTEOARTHRITIS, and PAGET'S DISEASE. Nutritional Disorders Nutritional deficiencies that result in bone damage include RICKETS in children and osteomalacia in adults, caused by a lack of vitamin D. In children, calcium and phosphate are poorly distributed on bones during development, resulting especially in deformity of the legs and arms. In adults, bones of the spine, pelvis, and legs become demineralized and the bones weaken.
These include diseases such as rickets which is caused by a lack of vitamin D. A lack of calcium leads to poor growth in children. At this tender life stage this is a very negative thing because children are still at the peak of their physical development. The malnutrition could have caused stunting which is because the malnutrition hinders growth in their height and weight. Sometimes stunted growth can be permanent and a child may never be able to return to a normal height or weight.
The body can manufacture only vitamin D; all others must be derived from the diet. Lack of them causes a wide range of metabolic and other dysfunctions. In the U.S., since 1940, the Food and Nutrition Board of the National Research Council has published recommended dietary allowances (RDA) for vitamins, minerals, and other nutrients.
Vitamin D is a necessary component for calcium absorption to prevent boss loss. Nutritionally our body can create vitamin D by sun exposure however many factors can prevent our bodies to create vitamin D such as using sunblock or not getting enough sun exposer from daily routine. Vitamin D can be found in many foods that we such as milk including almond milk, eggs yolks, saltwater fish, and liver. Other vitamins that can help prevent bone loss are vitamin A and C. Vitamin C is an antioxidant which helps reduce oxidative stress which can have a negative effect on the cells in the body. This helps protect against inflammation which takes away calcium from the bones. Vitamin C can be found in many foods such as papaya, bell peppers, broccoli, Brussel sprouts, strawberries, pineapples, oranges and kiwifruit and fruit juices have supplement vitamins. Vitamin A is important for bone growth, vision, cell division and cell differentiation. There are two different forms of vitamin A are retinol and beta-carotene. Retinol can be found in meat, poultry, fish and dairy products while beta-carotene can be found in fruits, vegetables and
Rickets is a bone disease that occurs in children as a result of a Vitamin D deficiency. This disease, which was nearly eradicated in the early 20th century, has become a re-emerging health concern for various countries in the past ten years. Certain factors such as poor nutrition as a result of low socioeconomic status or high concentrations of melanin in the skin can increase the chances of getting rickets. Sufficient Vitamin D levels are crucial to the functioning of the body, especially in the absorption of calcium. This essay will examine the causes, symptoms, pathogenesis, diagnosis and treatment of rickets; as well as the importance of Vitamin D and calcium in the prevention and treatment of this disease.
My average intake is 66 mg. it is lower than the required Vitamin C intake. Deficiency in Vitamin C can develop scurvy, if vitamin C is missing on our diet. Oranges, lemon and other citrus fruits, bell pepper, kiwi broccoli, berries, tomatoes and papayas are rich in Vitamin C . Lack of Vitamin D on diet can develop rickets to small children. The required intake for this vitamins is 15microgram and my report is zero. Vitamin D can be achieved from exposure of skin to ultra violet rays of the sun. Vitamin E is responsible for transmission of nerve impulses, body weakness and eye problem that can cause blindness. My nutrient intake for Vitamin 10 mg AT and the require intake is 15 mg AT, which is 5 mg lower than the require amount. Food related to Vitamin E are green leafy vegies such as spinach, kale are rich in Vitamin E, in addition, broccoli, hazel nuts, squash and pumpkin are also rich in Vitamin E. My vitamin K intake is 3 microgram, way too low compared to the requirement which is 90 microgram. Vitamin K deficiency can cause hemorrhagic disease of new born. Food that gives Vitamin K are green leafy vegetables such as kale and spinach, canola oils, olive oils, and
Vitamin D plays an integral role in multiple systems in the human body, from its function in Calcium and Phosphorus metabolism, to modulation of the immune and reducing the risk of cardiovascular diseases (Grober et al. 2013). Unfortunately, factors such as diet, geographic position, and skin pigmentation are contributing to an increase of prevalence of Vitamin D deficiency around the world, consequently leading to a higher rate of associated illnesses. Namely, Cardiovascular Diseases such as Coronary Artery Disease (CAD), Hypertensive Vascular Disease, and Myocardial Infarction have been shown to be more common in people with lower levels of Vitamin D in their system (Lavie, Lee & Milani 2011).
Chambers, C. D., Polifka, J. E., & Friedman, J. M. (2008). Drug safety in pregnant women and their babies: ignorance not bliss. Clinical Pharmacology & Therapeutics, 83(1), 181-183.
The fetus relies on the its mother for nutrition which is why it is important that a mother maintains a healthy diet and nutrition. Mothers who fail to intake the necessary proteins, vitamins, and minerals during pregnancy is subjected to the malformation of their child. Maternal age is as well associated with the unpleasant pregnancy outcomes. For example, in adolescence the mortality rate of an infant is higher than to mothers of older age. When women of age 35 years or older has become pregnant the risk that the child will have Down syndrome increases. Emotional states and stress during pregnancy can have long term consequences such as having a child with emotional or cognitive problems, attention deficit hyperactivity disorder, and language delay. It is concluded that mothers who suffer from depression during pregnancy can be linked to preterm birth, low weight at birth in full-term infant, and an increase risk that depression will develope in the adolescence. Not only does maternal characteristics influence the prenatal development of the offspring but so does the paternal. A father who smokes around the pregnant mother leads to a risk of early pregnancy loss and leukemia may also arise from second hand smoking. The father who is of age 40 or older is at risk of
There are many women who do not get the quality care, whether it is because of not being educated or not have women health facilities. There are too many women who do not understand the importance of screenings and tests. I plan on working in a rural area to be able to reach out to the women who have limited access to this vital health information. As a nurse, I aspire to reach out to all people of the community, but educating women of the health of them and their babies is my passion. In doing so, I would like to raise awareness of the risk of vitamin and nutrient deficiencies while breastfeeding. This could be harmful for both mother and child. For example, vitamin D, which is essential in absorbing calcium is amongst one of the most common deficiencies in breastfeeding infants.(cite) Milk from the mother contains very little vitamin D, so the baby must have supplementation in order to get daily requirement. (cite) If the baby is not able to absorb calcium, they will develop hypocalcemia. Not many women are aware of this, because care providers are neglecting to tell them until it is too late. Though physicians are aware, they tend to brush it off as if it is unimportant. This happens especially in southern states that get more sunshine. It is very strange that that though we encourage mothers to breastfeed, but are not educating them of these possible deficiencies and how to prevent them as we should. I want to inspire