Bone diseases most directly influence the ability to walk or to move any part of the body--hands, limbs, neck, and spine. They are related to joint disorders--ARTHRITIS,
COLLAGEN DISEASE, DISLOCATION of joints, and RHEUMATISM. The medical specialty pertaining to bone disorders is
ORTHOPEDICS. Fractures are the most common bone disorders. They can occur as the result of an accident or be secondary to metabolic diseases. Fractures are life-threatening to aged people having the metabolic bone disease
OSTEOPOROSIS, in which bones become porous and brittle. A person, mostly women, having osteoporosis may break a hip during a fall and possibly die from complications. Birth Defects
Congenital bone diseases constitute a wide spectrum, ranging from the unimportant--for instance, mild bow legs--to severe lesions, such as spina bifida, in which the lower end of the spine fails to develop properly and the baby is born with paralysis and misshapen vertebrae. Congenital diseases may have hormonal bases: for example, fibrous DYSPLASIA, in which fibrous tissue replaces that of some bones, often results in bone deformity; in addition, some girls with this disease physically mature so early that they are capable of pregnancy and childbirth at the age of seven.
Congenital defects also may have genetic bases, as in families who have extra fingers or toes or in the disease osteogenesis imperfecta, in which children have such brittle bones that many are fractured. Disorders of growth and development include several kinds of dwarfism and gigantism.
Bones or limbs may develop deformity as the result of known causes, such as the infection poliomyelitis, or unknown or variable causes, such as curvature of the spine (SCOLIOSIS) or
CLUBFOOT. Infections Infections of bone, called osteomyelitis, are usually caused by pus-producing bacteria, especially Staphylococcus and
Streptococcus. Before the development of antibiotics, children frequently contracted this disease. Today bone infections are introduced primarily through fractures and during surgical operations. People infected with syphilis, tuberculosis, leprosy, or yaws are susceptible to bone damage. Metabolic Disorders Metabolic abnormalities often involve defects in the storage of minerals, particularly calcium and phosphate ions, in the skeleton. Diseases of the kidney can cause a metabolic imbalance of phosphate and calcium so that weakening of the bone occurs.
Other metabolic bone diseases are osteoporosis, gout, OSTEOARTHRITIS, and PAGET'S
DISEASE. Nutritional Disorders Nutritional deficiencies that result in bone damage include
RICKETS in children and osteomalacia in adults, caused by a lack of vitamin D. In children, calcium and phosphate are poorly distributed on bones during development, resulting especially in deformity of the legs and arms. In adults, bones of the spine, pelvis, and legs become demineralized and the bones weaken. SCURVY--caused by a lack of vitamin C--also affects bone tissues. A study in the late 1980s indicated that the mineral boron is nutritionally important, as well.
Apparently, it reduces loss of the bone minerals
Osteoporosis comes from the latin word meaning “porous bone”. If you were to look closely at a bone you could see there are these small spaces on the bone which is good, now if you look at someone who suffers from osteoporosis you will see these spaces are much larger. As these spaces become larger it takes away from the strength and integrity of the bone making it grow weak and thin. Osteoporosis is most common in women over the age of 50 and gives them a higher risk of fractures and or breaks especially common in the hips. While we know osteoporosis comes from a number of things it can be broken down to age, the hormonal changes most commonly seen in menopause and a lower intake of Vitamin D and Calcium. Age is the unpreventable factor that doctors or you cannot change. Hormonal changes can be fixed with supplements or hormone therapy along with ones intake of Vitamin D and Calcium. Hormone therapy, estrogen alone or the combination of estrogen and progestin have been proven to prevent and aide in the treatment of osteoporosis in
Her findings from this research was praised as she concluded that small supplementary feeding with fruits, milk and wheat germ improved the growth of school children. She also found out that the over dosage of Vitamin D produced brittle bones and calcification of soft tissues. If that wasn’t enough, she continued her extensive research and showed that pantothenic acid is essential for normal pigmentation of hair and skin. Lastly she was intelligent enough to prove that the bone density of woman decreased between 50 and 65 years of
In order to study the gene mutation that is supposed to cause Paget’s Bone Disease researchers had to have viable candidates to host the gene mutation. They found the best candidate to host the gene mutation in mice so they implanted the gene mutation in embryos of mice offspring. The researchers hypothesized that p62P394L is sufficient to induce PDB, especially since the p62 gene is responsible for encoding 62 kDa protein which functions in signaling osteoclast precursors. Results were found by fixing the first through fifth lumbar vertebra of four, eight, and twelve month old homozygote, heterozygote and WT littermates in 10% buffered formalin for 24- 48 hours. The first through fourth vertebra were then completely decalcified while the fifth was not. Longitudinal sections of both decalcified and undecalcified vertebra were cut, mounted on glass slides and stained to analyze. The mice with p62P394L had histologically normal bones, indicating that p62 mutation is not enough to induce Paget’s disease of the bone in vivo, there are additional factors necessary. Knowing osteitis deformas is due to hyper responsive multinucleated osteoclasts, it seemed a sensible suggestion. However, there are many other variables that should be factored when considering possible causes for osteoclast hyperformation. If p62P349L is present, doesn’t necessarily mean a person will get PDB, though an environmental factor such as measles could easily open up transduction pathways that could eventually lead to pagetic bone lesions. We find this study to be a stepping stone for future researchers to use in order to actually identify what causes Paget’s bone disease. (Hiruma, Kurihara, Subler, Zhou, Boykin, Zhang, Ishizuka, Dempster, Roodman & Wi...
Most serious structure with regards to Osteogenesis Imperfecta , the greater part of these cases are endless in great conditions, which means the vast majority of the cases wind up in premature birth by the guardians or unnatural birth cycle by nature . In any case, a portion of the uncommon cases that do survive present breathing challenges much of the time deadly at or soon after birth, regularly because of respiratory
There are many different diseases that can affect our skeletal system and Osteoporosis is one of them. Osteoporosis lessens bone strength and bone density (amount of bone mineral in bone tissue), which will lead to fragile bones. It mainly affect the hips, ribs, spine, and wrists. Male or female, at any age, can get this but it is mostly occurs in older women (Team, 2016). Osteoporosis is very common, there are more than 3 million cases a year. There are many causes/risk factors, symptoms, and some treatment cases. About 54 million Americans have Osteoporosis and low bone mass (Foundation, 2016).
10. What parts of the skeleton are most vulnerable to the ravages of osteoporosis? Since the elderly are at risk of getting osteoporosis especially in older women. The most common are areas of the body to get this disease would be the spine, ribs, wrist, hip and in the arm. Which in this case was the reason Margaret obtained her hip fracture.
Osteoporosis is a condition, in which bones are weak from deterioration, loss of bone mass, and quality bone strength. Osteoporosis usually triggers postmenopausal women (women who have not had their period for a whole year), or older men and women. Some risks both older men and women endure when experiencing osteoporosis are decreased calcium and bone fractures. These symptoms or effects can all be caused by weight loss, smoking, age, ethnicity, genetics, medications, bone structure, and certain diseases that can later on contribute to osteoporosis, such as rheumatoid arthritis. Osteoporosis may be prevented by going to drug therapy to stop alcoholism and smoking, a sufficient amount of calcium intake, and exercising such as jogging, walking, and aerobics.
Osteoporosis is a serious disease that leads to a faster than normal loss of the bone density, which puts the bone at a higher risk for fractures. In order to understand the causes of Osteoporosis, it is important to understand how bones are formed. Bone is a living tissue that is made mainly of collagen, calcium phosphate, and calcium carbonate. The mixture of collagen and calcium gives the bone strength and flexibility. The body deposits new bones and removes old ones; moreover, there are two types of bone cells that control the reproduction of bones. Cells called osteoclasts breakdown bone tissues thus, damaging the bone. Once the damaged bone is removed, cells called osteoblasts, use minerals including calcium and phosphate from the blood stream to make new healthy bone tissues. In order for osteoblasts and osteoclasts to work properly, hormones such us thyroid, estrogen, testosterone, and growth hormones are
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a rare genetic disorder with the main characteristic being that the bones break very easily, usually for no apparent reason. The major cause of osteogenesis imperfecta is a mutation in the genes that produce collagen. Collagen is the main protein that works toward the production of connective tissue. Individuals with this disorder will produce less collagen than needed, which causes the bone development to be endangered. This could result in bone deformities. There are four types of osteogenesis imperfecta, and in all four types you will see bone fragility with multiple fractures and bone deformities.
Other common symptoms are gum diseases, tooth decay, premature graying of hair, arthritis low back pain, leg cramps, nail growth. Fragility fracture occurs when a person falls from a standing position or a low height and breaks a bone that would not break in a person with a healthy bone. Heritability of bone mass estimated to account for 60-90% of its variance (Kaczkowsi, 2013). Osteoporosis risk factors can change, and others cannot be altered the factors that cannot change are sex, race and ethnicity for example Asian and Caucasian have a higher risk of Osteoporosis than African American and Hispanic women, age, and genetic factors. Risk factors that can change are low sex hormone levels, eating disorders, depression, low intake in calcium and vitamin D, getting the right amount of exercise, and
Since ancient times vitamin D has been the predominant cause of bone deficiencies.1 However, it was not in till the seventeenth century when both Dr. Daniel Whistler and Professor Francis Glisson made the first scientific description of a vitamin D deficiency.2 During the mid-seventeenth century there was an increase amount of children that were diagnosed with the bone disease called rickets.2 The cause of the rickets was determined to be associated to the lack of sunlight. A German researcher Kurt Huldschinsky came to the conclusion that when infants were exposed to ultraviolet light rays they became cured of rickets2. He stated that a substance in the skin was the potential source of the cure.2 In 1922, American scientist Elmer McCollum proved that when cod liver oil was heated; the beneficial effects of vitamin A in the oil were reduced.2 However, the oil remained effective in curing rickets leading McCollum to reason that a nutrient different from vitamin A was present in the oil. As a result, he named this nutrient vitamin D, which became the fourth vitamin to be discovered and named.2 Additionally, shortly after 1918, vitamin D was also discovered by an accidental experiment that included a group of scientists curing dogs affected with rickets by feeding cod liver oil to them.1
The big picture. Where the two schools of medicine differ is in philosophy. Doctors of osteopathy "treat people, not just symptoms," says Karen Nichols, dean of the Chicago College of Osteopathic Medicine. "The course list looks exactly the same, but the M.D.'s focus is on discrete organs. The osteopathic focus is that all of those pieces are interrelated. You can't affect one with out affecting another." That means paying more than simple lip service to the idea of the "whole" patient: It means that diagnosis and treatment rely on an examination of a person's environment and family and general situation as well as his or her body. Not surprisingly, about 65 percent of the nation's 52,000 licensed osteopaths (by comparison, the country boasts at least 900,000 M.D.'s) are primary-care physicians. The American Association of Colleges of Osteopathic Medicine has a description of osteopathic training, as well as short profiles of 20 schools, at www.aacom.org. The D.O. programs and their contact information are listed in the directory section of this book.
Rickets is a bone disease that occurs in children as a result of a Vitamin D deficiency. This disease, which was nearly eradicated in the early 20th century, has become a re-emerging health concern for various countries in the past ten years. Certain factors such as poor nutrition as a result of low socioeconomic status or high concentrations of melanin in the skin can increase the chances of getting rickets. Sufficient Vitamin D levels are crucial to the functioning of the body, especially in the absorption of calcium. This essay will examine the causes, symptoms, pathogenesis, diagnosis and treatment of rickets; as well as the importance of Vitamin D and calcium in the prevention and treatment of this disease.
Osteoporosis is a disease in which the bones become so weak and brittle that even a cough can cause enough stress on the bone that it will cause the bone to facture. The most commonly broken bones are the hip, wrist, and the spine. Although it affects men and women of all races, post-menopausal Caucasian and Asian women are more commonly affected than those of other ethnicities and sexes. In fact, thirty percent of all post-menopausal women in the US and Europe will be diagnosed with Osteoporosis and at least 40 percent of those will suffer from a fracture in their lifetime.
Bone cancer is classified into primary bone cancer & secondary bone cancer. Basically, Primary bone cancer starts in the bone; then the cancer initially forms in the cells of the bone; while the secondary cancer starts elsewhere in the body and gets spread to the bone.