Ginkgo Biloba Research Paper

1452 Words3 Pages

Ginkgo Biloba, or maidenhair tree extract, has been used in Chinese medicine for centuries due to its pharmaceutical and medical properties. Ginkgo Biloba was introduced into the Western World in the 18th century. Nowadays, standardised Ginkgo Biloba extract EGb 761 is one of the most popular herbal supplements taken for potential memory improvement. This extract has many pharmacologically active components; the unique ingredients are terpene trilactones – ginkgolides A, B, C and bilobalide, which appear to be potentially antagonising inhibitory receptors in the brain. Ginkgo Biloba extract protects the neurons from oxidative damage and potentially prevents the progression of tissue degeneration. Numerous studies have been carried out to examine …show more content…

3069 individuals aged 75 years or older with normal cognition or mild cognitive impairment were assessed every 6 months with a median follow-up of 6 years. Dekosky et al. (2008; see also Snitz, O’Meara, Carlson, Arnold, Ives, Rapp, Saxton, Lopez, Dunn, Sink & DeKosky, 2009) concluded that Ginkgo at a dosage of 120 mg twice per day was ineffective in reducing either the overall occurrence rate of dementia or Alzheimer’s disease incidence in elderly individuals with normal cognition or with mild cognitive impairment. Ginkgo and placebo did not differ, and therefore, Ginkgo Biloba extract is not effective in preventing or delaying the onset of all-cause dementia or Alzheimer’s disease in elderly people. These studies could not demonstrate any evidence of the effectiveness of Ginkgo Biloba neither on cognitive change nor on specific cognitive domains of memory.

However, other clinical studies on EGb 761 challenged the effects and benefits on the use of Ginkgo Biloba. In 2008, the German Institute for Quality and Efficiency in Health Care (IQWiG) published an extensive meta-analysis of clinical studies, which …show more content…

This study used Mini-Mental State Examination and assessed the association between the intake of EGb 761 and another nootropic medication - piracetam and cognitive function of elderly adults over a 20-year period. Amieva et al. (2013) concluded that cognitive decline in a non-demented elderly individuals was lower in the participants’ group which reported using EGb 761 than in the ‘neither treatment’ group. Therefore, this effect may be a specific medication effect of EGb 761: since it was not observed for piracetam. Additionally, the study by Gavrilova, Preuss, Wong, Kaschel & Bachinskaya (2014) concluded that NPI score decreased in the EGb 761-treated group and, therefore, concluded that Ginkgo Biloba extract improved neuropsychiatric symptoms and cognitive performance in patients with mild cognitive

More about Ginkgo Biloba Research Paper

Open Document