On the other hand, statins reduce coronary events and mortality in patients with ischemic heart disease. Moreover, they lower the risk of ischemic stroke and treat hyperlipidemia. In contrast, fibrates activate peroxisome proliferator-activated receptor alpha, PPAR-alpha, this protein activates enzyme lipoprotein lipase that leads to decrease the formation of the very low-density lipoprotein (VLDL), which is converted into LDLs, and triglycerides. Also, this activation increase the HDL concentration. Statins and fibrates side effects are somewhat similar.
The enzyme HMGCoA reductase produces cholesterol in the liver (Khaleghi, 2011, p. 166). By blocking the enzyme, the liver produces less cholesterol. One reason statins are widely used is because most people taking statins do not have serious side effects and statins can reduce LDL levels by up to sixty percent (Khaleghi, 2011, p. 167). Statins will impact cholesterol levels in about four to six weeks. Studies show statins decrease the risk of heart attack, stroke, peripheral arterial disease and death in men and women (Khaleghi, 2011, p. 167).
Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. Plos one 5 (9): 1-11. Saposnik, G., Ray, J., Sheridan, P., McQueen, M., & Lonn, E. 2009. Homocysteine-Lowering Therapy and Stroke Risk, Severity, and Disability Additional Findings From the HOPE 2 Trial. Stroke, 40(4), 1365-1372.
Reducing the cost of proton pump inhibitors by adopting best practice. Quality In Primary Care, 17(1), 15-21. Bernard, L., Fendrick, A., Inadomi, J., & McIntyre, L. (2013) Center for Biotechnology Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs. Am J Gastroentero Coggins, M. O. (2014).
The goal of a Ketogenic Diet and its relationship to decreasing acne vulgaris can be viewed through a series of tests and the pathways that these ketones follow. When observing ketosis in these individuals it was shown that there were several reduced markers of have inflammation in the acne lesions. Insulinemia was determined to have been decreases and this altered the pathway that IGF-1 has. Because of this it can be determined to be an excellent factor of decreasing the prevalence and aggression of acne vulgaris (Paoli, et al., 2012). The blood glucose levels were taken and the average was... ... middle of paper ... ... increase in acne lesions and sebaceous glands.
Statin therapy effects the cardiovascular system in such a way that it lowers the blood lipid and low-density lipoprotein cholesterol levels, reducing coronary events that lead to death (Liao, Hsieh, Hung, Huang, Lin, Wang & Wu, 2013). An individual with elevated LDL cholesterol [100 mg/dL (2.6 mmol/L)] and lower levels of high-density lipoprotein cholesterol is at a higher risk of developing coronary heart disease (Buono, Petrazzouli, D'Addio, FArinaro & Soler , 2013). A study sponsored by the Department of Veterans Affairs stated that patients who had elevated their low levels of HDL cholesterol with gemfibrozil (a statin therapy) had a decrease in coronary episodes (Bloomfield, 2006). Studies have been performed in showing evidence that immediate release niacin added to statin therapy will assist in elevating HDL cholesterol. It is not known whether the administration of extended release niacin, along with statin therapy, will assist in elevating the HDL cholesterol.
Neubauer, D. (2009). Current and new thinking in the management of comorbid insomnia. The American Journal Of Managed Care, 15 SupplS24-S32. Otmani, S., Demazières, A., Staner, C., Jacob, N., Nir, T., Zisapel, N., & Staner, L. (2008). Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers.
The product diaglitazone along with rosiglitazone and pioglitazone are the currently approved agents from the thiazolidinedione class of antidiabetic medication which are widely used to lower blood glucose levels. Successful therapies for Type 2 Diabetes should result in the reduction of complications from diabetes in addition to its primary focus of reduction of serum glucose levels. The thiazolidined... ... middle of paper ... ...scular events in diabetic patients taking Rosiglitazone. Works Cited 1 N Engl J Med 2007, 356; 24: 2457-2471, Nissen and Wolski; Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes 2 Journal of Lipid Research, 37 (5): 907. (1996); Schoonjans et al; Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression 3Molecular Cell, Vol.
Statins and fibrates are two classes of lipid-regulating drugs. The statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme A, HMG-CoA, reductase, an enzyme involved in cholesterol synthesis, especially in the liver. While fibrates, fibric acid derivatives, are a class of amphipathic carboxylic acids. Clinical trials reveal that statins reduce cardiovascular event rate and all-cause mortality in a broad range of demographic and risk populations. Furthermore, six statins are available in the United States; cerivastatin, a type of statin, was withdrawn from the market due to excess rates of morbidity.
delves into the effectiveness of early infliximab usage with maintenance and induction therapy in Crohn’s disease. Essentially the study is directed at improving Infliximab which is carried out through numerous control measures contrasting its affects with Melamine, Azathiorpine and Prednisolone. A small group of patients were subdivide into 3 groups of A, B and C and were subject to orally ingesting the medications previously stated. By monitoring the activity index score over a 12 month and 24 month observation period, the relapse rate would ultimately determine the efficacy of the medication. Seung Lee et al.