Childhood Asthma: Developing New Therapies

Asthma is the leading cause of hospital admissions during childhood. Kumar and Robbins give an accurate definition of asthma as “a chronic inflammatory disorder of the airways that causes recurrent episodes of wheezing, breathlessness, chest tightness, and cough, particularly at night and/or early in the morning” (489). Asthma is a terrifying disease, especially in children, because of the sudden attacks that could claim lives if not treated immediately and effectively. Despite recent advancements in available drugs and overall therapy, the incidence of childhood asthma is rising (Dolovich 373). In order to effectively treat and eventually prevent the onset of asthma, more effective and economical therapies are necessary; although current knowledge has already led to breakthroughs in new drug treatments, the rising incidence rate calls for more. Therefore, to advance the effectiveness of asthma therapies, researchers must first look at the changes caused by the disease, the risk factors that cause or exacerbate it, and lastly understand the mechanisms of the current drugs.

Understanding the pathogenesis of asthma is a solution to creating treatments that are more effective. “For more than two decades now, asthma has been recognized as a chronic inflammatory disease involving inflammation of both the central and peripheral airways” (Tulic 71). This chronic inflammation results in structural changes in the airways of the asthmatic patient, referred to as airway remodeling. Airway remodeling is the cause of the symptoms seen in asthmatics during an attack like severe dyspnea, wheezing or difficulty in expiration (Kumar and Robbins 492). There are five major aspects of the body affected by asthma, mostly due to chronic infl...

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... “The Best Step-Up Regimen for Uncontrolled Asthma in Children.” Medscape Today. 25 May 2010. Web. 01 June 2010. .

Li, James T., ed. Pharmacotherapy of Asthma. Vol. 212. New York: Taylor and Francis, 2006. Print.

Martinez, Fernando. “The Natural History of Asthma during Childhood.” Silverman 29-35.

Pedersen, Soren. “Early Pharmacologic Intervention of Asthma: How Early and What Treatment.” Pedersen and Szefler 213-251.

Pedersen, Soren, and Stanley J. Szefler, eds. Childhood Asthma. Vol. 209. New York: Taylor and Francis, 2006. Print.

Silverman, Michael, ed. Childhood Asthma and Other Wheezing Disorders. 2nd ed. London: Arnold, 2002. Print.

Singh, Dave, and Ashley Woodcock. “β-Agonists.” Li 29-63.

Tulic, Meri K., et al. “Developmental Features of Airway Remodeling.” Pedersen and Szefler 71-97.