In the articles a common goal was researchers feel that the loss and gain function of LRP5 affects bone formation, causes osteoporosis, and high bone mass. Bone formation forms cartilage growth and replacement by bone is responsible for most growth in vertebrates. Bones is living, growing tissue and it made of collagen and calcium phosphate that adds strength and hardness. However, Osteoporosis has become a major health problem due to unknown cause. When bone resorption occurs too quickly or when bone replaces occurs too slowly it known as osteoporosis. Researchers have compared images of a healthy bone and a bone with osteoporosis the difference among the two where the holes and spaces in them. A bone with osteoporosis holes and spaces were larger than a healthy bone. …show more content…
This protein is involved in the WNT signaling pathway acting as a coreceptor for WNT …” Loss of function mutation in the gene for low density lipoprotein receptor related protein 5 has been shown to cause osteoporosis. WNT role associated with LRP5 is that is controls multiple aspect of skeletal development. Pathways activated by WNT increase bone mass through stimulation of pre- osteoblast replication. LRP5 bind to several different molecules such as WNT and DKK and co receptor protein Frizzled. The importance of the Wnt/β-catenin signaling pathway in patterning, development, and maintenance of the human skeleton is underscored by the number of human bone diseases connected with mutations in this pathway. Early in skeletal development, WNT signaling controls pattern formation before skeletal elements are laid down, and abnormal WNT signaling is associated with defects of the human skeleton. Components of the WNT-LRP5 signaling pathway. The main components of the LRP5 signaling is the B-catenin is held in a
Osteoporosis comes from the latin word meaning “porous bone”. If you were to look closely at a bone you could see there are these small spaces on the bone which is good, now if you look at someone who suffers from osteoporosis you will see these spaces are much larger. As these spaces become larger it takes away from the strength and integrity of the bone making it grow weak and thin. Osteoporosis is most common in women over the age of 50 and gives them a higher risk of fractures and or breaks especially common in the hips. While we know osteoporosis comes from a number of things it can be broken down to age, the hormonal changes most commonly seen in menopause and a lower intake of Vitamin D and Calcium. Age is the unpreventable factor that doctors or you cannot change. Hormonal changes can be fixed with supplements or hormone therapy along with ones intake of Vitamin D and Calcium. Hormone therapy, estrogen alone or the combination of estrogen and progestin have been proven to prevent and aide in the treatment of osteoporosis in
In order to study the gene mutation that is supposed to cause Paget’s Bone Disease researchers had to have viable candidates to host the gene mutation. They found the best candidate to host the gene mutation in mice so they implanted the gene mutation in embryos of mice offspring. The researchers hypothesized that p62P394L is sufficient to induce PDB, especially since the p62 gene is responsible for encoding 62 kDa protein which functions in signaling osteoclast precursors. Results were found by fixing the first through fifth lumbar vertebra of four, eight, and twelve month old homozygote, heterozygote and WT littermates in 10% buffered formalin for 24- 48 hours. The first through fourth vertebra were then completely decalcified while the fifth was not. Longitudinal sections of both decalcified and undecalcified vertebra were cut, mounted on glass slides and stained to analyze. The mice with p62P394L had histologically normal bones, indicating that p62 mutation is not enough to induce Paget’s disease of the bone in vivo, there are additional factors necessary. Knowing osteitis deformas is due to hyper responsive multinucleated osteoclasts, it seemed a sensible suggestion. However, there are many other variables that should be factored when considering possible causes for osteoclast hyperformation. If p62P349L is present, doesn’t necessarily mean a person will get PDB, though an environmental factor such as measles could easily open up transduction pathways that could eventually lead to pagetic bone lesions. We find this study to be a stepping stone for future researchers to use in order to actually identify what causes Paget’s bone disease. (Hiruma, Kurihara, Subler, Zhou, Boykin, Zhang, Ishizuka, Dempster, Roodman & Wi...
The gene which is responsible for this disease, FGFR3, is located on chromosome 4 at 16.3, which is on the short arm near the telomere (4). Under normal circumstances, this gene forms fibroblast growth receptor 3 which interacts with a protein to begin a stream of signals that contribute to bone development and maintanence; it is also thought that this gene is also important in other tissue development (6, 7, 10-12). Some of the known pathways involved with FGFR3 are STAT1/3, STAT5, MEK1, ERK1, and MAP kinase signaling. Chondrogenesis and osteogenesis are two processes managed by these pathways and are greatly affected by a mutation (13-15). The sections of these pathways that involve and are affected by the mut...
So far, various techniques have been used for reconstruction and regeneration of maxillary and mandibular bone defects. Autogenous bone grafting, guided bone regeneration (GBR), distraction osteogenesis and nerve transpositioning are among these regenerative techniques (1-8). Decision making for the treatment could be influenced by the type, size and location of the bone defects (2, 3, 9, 10). GBR had high success rate in treating small alveolar defects such as dehiscence or fenestration. Regenerative bony walls around the defect with ingrowing blood vessels can begin osteogenesis (11) larger bone defects with insufficient regenerative walls and an low quality avascular bed need varied amount of autogeneous bone graft from extra oral or intra oral donor sites, however, the patient may suffer from complications in donor site as well as bone graft resorption.(10, 12-15)
The skeletal system consists of 206 bones and has other body attachments that assist in connecting them which are tendons, ligaments, and cartilage. The skeletal system provides vital functions for the human body. The functions this system provides are support, movement, protection, blood cell production, storage for calcium and endocrine regulation. Bone serves as the basic unit of the human skeletal system. Ossification is characterized as a process that produces new bone. This process is also known as bone formation. Bone formation consists of two types of development. They are intramembranous and endochondral formation. Intramembranous ossification takes place when cells within the membrane change and become osteochondral progenitor cells.
Osteoporosis is a condition, which advances with age, resulting in fragile, weak bones due to a decrease in bone mass. Externally osteoporotic bone is shaped like normal bone, however it’s internal appearance differs. Internally the bone becomes porous due to a loss in essential minerals, including phosphate and calcium. The minerals are loss more quickly than they can be replaced and in turn cause the bones to become less dense and weak. The bones become prone to fracture, due to their weakness. Therefore the awareness of the disease tends to occur after a fracture has been sustained. The bones most commonly affected are the ribs, wrist, pelvis and the vertebrae.
Osteoporosis is a serious disease that leads to a faster than normal loss of the bone density, which puts the bone at a higher risk for fractures. In order to understand the causes of Osteoporosis, it is important to understand how bones are formed. Bone is a living tissue that is made mainly of collagen, calcium phosphate, and calcium carbonate. The mixture of collagen and calcium gives the bone strength and flexibility. The body deposits new bones and removes old ones; moreover, there are two types of bone cells that control the reproduction of bones. Cells called osteoclasts breakdown bone tissues thus, damaging the bone. Once the damaged bone is removed, cells called osteoblasts, use minerals including calcium and phosphate from the blood stream to make new healthy bone tissues. In order for osteoblasts and osteoclasts to work properly, hormones such us thyroid, estrogen, testosterone, and growth hormones are
Osteoporosis is a systemic, debilitating disease of the skeleton, characterized by significantly decreased bone mass in combination with the deterioration of bone microarchitecture. Osteoporosis has three types of categories the first category is type 1 which occurs in women after menopause and results from declining levels of estrogen and other sex hormones in the body, this could also occur in men due to low levels of the sex hormone testosterone. Type 2 is called Senile Osteoporosis, which occurs in elderly men as well as elderly women because of decreased bone formation due to aging. Type 3 is caused by long term use of medication usually with steroids and drugs to treat elipsy. Osteoporosis which literally means “Porous Bone”,
In Bone Gap, by Laura Ruby, perception is everything. The people living in the town love to gossip about everything they see, whether it be accurate or not. For this reason, point of view adds a lot to the novel as the story is told from the views of many different people. The literary device of point of view is very important because the story can greatly change depending on the narrator’s own perception of what is occurring.
Television has affected every aspect of life in society, radically changing the way individuals live and interact with the world. However, change is not always for the better, especially the influence of television on political campaigns towards presidency. Since the 1960s, presidential elections in the United States were greatly impacted by television, yet the impact has not been positive. Television allowed the public to have more access to information and gained reassurance to which candidate they chose to vote for. However, the media failed to recognize the importance of elections. Candidates became image based rather than issue based using a “celebrity system” to concern the public with subjects regarding debates (Hart and Trice). Due to “hyperfamiliarity” television turned numerous people away from being interested in debates between candidates (Hart and Trice). Although television had the ability to reach a greater number of people than it did before the Nixon/Kennedy debate, it shortened the attention span of the public, which made the overall process of elections unfair, due to the emphasis on image rather than issue.
The musculoskeletal system is comprised of bones, joints, cartilage, tendons, ligaments, fascia and muscles. Together these body parts work to establish a framework that is the musculoskeletal system. This framework is what gives the body its shape, form, and figure. It stabilizes the body as well as supplies the structural support. The musculoskeletal body features not only provide a framework for your body but allows your ability to create movement. These movements are monitored by the musculoskeletal components which then determine your degree of flexibility. Overall the amount of energy your body uses comes almost entirely from these musculoskeletal functions. Which makes sense because it
The skeletal system is composed of two hundred and six bones in the human body. Functions such as the tendons, cartilage, and ligaments connect the bones and tissues together. Bone tissues make up about 18% of the weight of the human body. There are two types of tissue inside the bones. They consist of; compact bone and spongy bone. First, compact bone depicts the main shaft of long bones in the human body such as the arms and legs. Its tissue is dense and hard and it also makes up the outer layer of most bones in our body. Meanwhile, spongy bone tissue is made up of smaller plates occupied with red bone marrow. Mostly, it is found at the ends of long bones such as the head of the femur.
Synthetic biology, also known as synbio, is a new form of research that began in the year 2000. The Action Group on Erosion, Technology and Concentration (ETC Group) says that synthetic biology is bringing together “engineering and the life sciences in order to design and construct new biological parts, devices and systems that do not currently exist in the natural world’ (Synthetic Biology). Synthetic biology is aiming to create safer medicines, clean energy, and help the environment through synthetically engineered medicines, biofuels, and food. Because synthetic biology has only existed for fourteen years, there is controversy involving its engineering ethics. In this literature review, I am going to summarize and correlate the International Association for Synthetic Biology (IASB) Code of Conduct for Gene Synthesis, the impact of synthetic biology on people and the environment, and the philosophical debates.
Bone cancer is classified into primary bone cancer & secondary bone cancer. Basically, Primary bone cancer starts in the bone; then the cancer initially forms in the cells of the bone; while the secondary cancer starts elsewhere in the body and gets spread to the bone.
The Skeletal System, also known as the Skeleton make up a framework that support the body and protect the organs. The Skeleton consists of the bones and joints of the body. In the human body there is 300 bones at birth, these then fuse together to make 206 bones in a fully grown adult. The Skeleton is made up of two divisions: The axial and appendicular Skeleton.