Nerve Regeneration Essay

Nerve Regeneration Essay

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Peripheral neuropathy is damage to the peripheral nervous system (PNS). The PNS helps to relay sensory information to the brain and spinal cord. The brain, in turn, will send communication back to the PNS in order to perform specific motor functions. Damage to any part of the PNS can result in a variety of symptoms, which can include tingling, prickliness, numbness, muscle wasting, and even paralysis. Peripheral neuropathies are known to have about 100 different types and are classified by which nerves they impact: sensory, motor, or autonomic. There are several causes for nerve injury, and some of these include physical trauma, autoimmune diseases, tumors, toxins, and metabolic disorders. Out of these, physical injury is the most common, and can occur as a result of accidents or falls. Nerve damage can have several outcomes, including completely severed, crushed, stretched, and even fully detached from the spinal cord. Once a nerve injury has occurred, there are several ways to diagnose the extent of damage. These can include a CT scan, MRI, Nerve Conduction Velocity (NCV), nerve biopsy, and a skin biopsy. Treatments are continuing to grow as more research becomes available, but there is optimism when it comes to stem cells and nerve regeneration.
There are several methods being used in nerve regeneration, but the journal article “ Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo” focuses on stem cells. Adipose-Derived Stem Cells (ASCs), have shown beneficial effects on peripheral nerve repair. Although it would seem logical to harvest Schwann cells for this purpose, the process is very traumatic, and ASCs are much...


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... promotes nerve healing and axon growth de novo. PlosOne, 6(3). Retrieved November 20, 2011, from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017899
Miller, B. (n.d.). Nerve injuries in military personnel focus of web site. Washington University in St. Louis. Retrieved November 20, 2011, from news.wustl.edu/news/Pages/12076.aspx
Peripheral Neuropathy Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS). (n.d.). National Institute of Neurological Disorders and Stroke (NINDS). Retrieved November 20, 2011, from http://ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm#183583208
Sulaiman, W. A., & Kline, D. G. (2006). Nerve surgery: A review and insights about its future. Clinical neurosurgery, 53, 38-47. Retrieved November 20, 2011, from www.cns.org/publications/clinical/53/pdf/cnb00106000038.pdf

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