There are new approaches and agents against certain types of cancer that are urgently needed. Some of the new agents use highly advanced technology utilizing nanoencapsulation that will improve the therapeutic index of the natural drugs. Nanoparticles for cancer therapeutics are rapidly evolving and are being introduced in an attempt to overcome several limitations of conventional small-molecule chemotherapeutics. Though chemotherapy is successful to some extent in certain cancers, it has several limitations (14). I will be discussing three natural products (Currcumin, Thymoquinone and Genistein) from plants that have anti-cancer effects. These three natural products have been studied for its antitumor mechanism against pancreatic cancer. The natural products have to be given in large quantities, due to its very short half-life and poor bioavailability. Therefore, to increase its bioavailability, they intend to load the natural products in stearically stabilized micelles and target them on receptors on plasma membrane of tumor cells. By delivering a cargo of chemosensitizers, which effectively block drug efflux from cancer cells, natural products can increase intracellular drug concentrations and significantly enhance the cytotoxic effect of various antitumor effects (14). The stearically stabilized components will have greater growth inhibitory, and apoptotic potential.
Cancer represents one of the most severe health problems worldwide and the development of new anticancer drugs and more effective treatment strategies are fields of utmost importance in drug discovery and clinical therapy (6). Among all cancers, pancreatic cancer is one of the worst. Even with the survival rat...
... middle of paper ...
...in Long, Yang Wan, Feng Luo, Xia Zhao, and ZhiYong Qian. "Curcumin-loaded Biodegradable Polymeric Micelles for Colon Cancer Therapy in Vitro and in Vivo." The Royal Society of Chemistry10 (2010): 1-10.
20. Kinghorn, Douglas A., Young-Won Chin, and Steven M. Swanson. "Discovery of Natural Product Anticancer Agents from Biodiverse Organisms." NIH Public Access 12.2 (2009): 189-96.
21. Davis, David A., Sarah H. Sarkar, Maha Hussain, Yiwei Li, and Fazlul H. Sarkar. "Increased Therapeutic Potential of an Experimental Anti-mitotic Inhibitor SB715992 by Genistein in PC-3 Human Prostate Cancer Cell Line." BMC Cancer 6.22 (2006): 1-9.
22. Chen, Dongfeng, Xubo Wu, Jiaxiang Wang, Baosan Han, Ping Zhu, and Chenghong Peng. "Morphological Observation of Interaction between PAMAM Dendrimer Modified SWCNT and Pancreatic Cancer Cells." Nano Biomed Eng 2.1 (2010): 60-64.
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Nanotechnology: The Future Here Now Webopedia defines nanotechnology as the “field of science whose goal is to control individual atoms and molecules to create computer chips and other devices that are thousands of times smaller than current technologies permit”. Current manufacturing processes use lithography to imprint circuits on semiconductor materials, at a size of less than one micron (1,000 nanometers), dealing with aggregates of millions of atoms. It is believed that this method is quickly approaching its physical limits.... [tags: Science Technology Essays]
2369 words (6.8 pages)
- The Bright Future of Molecular Nanotechnology On a cellular level, the biomedical technologies of today are crude and destructive. Even the most delicate surgery does not repair medical problems. Surgical methods tear away huge swatches of both damaged and healthy cells, and rely upon the body's own ability to heal itself. The drugs of today are developed by trial and error at a cost of millions of dollars, and disperse throughout the entire body, causing numerous side effects in tissues unaffected by the initial physiological insult the drug was intended to correct. Today's genetic screening can determine if a patient's genome contains specific aberrant genes, but can neither d... [tags: Technology Essays]
1469 words (4.2 pages)
- Thyroid Cancer is a thyroid neoplasm that develops in the thyroid gland. The thyroid gland consists of two large lobes that are connected by the isthmus and is located below the larynx on both sides of the trachea. The gland secretes hormones from the hypothalamus that may be stored in the colloid or released into the blood in capillaries. In the endocrine system, the thyroid gland secretes hormones that act on cells with specific receptors called target cells. When cancer develops in the thyroid, the production of hormones is disrupted.... [tags: Medical Research]
998 words (2.9 pages)
- The Use of Nanoparticles in medicine and Cancer Therapy Nanoparticles are at the best side of the quickly progressing area of nanotechnology. The potential for Nanoparticles in cancer malignancy treatments and pharmaceutical shipping are endless with novel new programs consistently being investigated. Multi-purpose Nanoparticles play a very important part in cancer malignancy treatments and pharmaceutical shipping. The papers best parts the newest success and progression in cancer malignancy treatments and pharmaceutical shipping.... [tags: Medical Innovation, Nanotechnology]
2134 words (6.1 pages)
- Title: Natural And Medical Treatments For Cancer Meta: A cancer diagnosis can be devastating, but combining Natural And Medical Treatments For Cancer may help. Treating cancer can heal other areas of your life. Natural And Medical Treatments For Cancer Your body 's cells are growing uncontrollably, ignoring genetic signals to stop. Natural And Medical Treatments For Cancer may stop that growth. Discover Natural And Medical Treatments For Cancer Cancer conjures images of chemo caps, nausea and cures seeming worse than the disease they treat.... [tags: Cancer, Oncology, Chemotherapy, Cancer staging]
1013 words (2.9 pages)
- 589,430 people from the United States are estimated to die from cancer in 2015 (ACI, 2015). Seeing a loved one die from cancer heartbreaking. Seeing a loved one suffer from the side effects of cancer treatment is just as hard. The battle to treat cancer has been stressful and harsh to patients. The most popular way to treat cancer today is through chemotherapy. Chemotherapy is a way of treating cancer using chemical substances, specifically anti-cancer drugs. A new and emerging way to treat cancer is nanotechnology.... [tags: Cancer, Oncology, Chemotherapy, Nanotechnology]
1022 words (2.9 pages)
- The Promise of Nanotechnology Nanotechnology is designing and building machines in which every atom and chemical bond is specified precisely (Hall 21). Products of nanotechnology are anything that is smaller than 100 nanometers. Nanotechnology is a broad term used for various parts of biomechanics. There are many promises of nanotechnology in the fields of environment, transportation and health. And this is just a small glimpse into the world of nanotechnology. But because nanotechnology is so broad and covers so many aspects of life, in this essay I will only discuss the promises in the health field.... [tags: Technology Nanotechnology ]
1128 words (3.2 pages)
- Nanotechnology “Imagine a technology so powerful that it will allow such feats as desktop manufacturing, cellular repair, artificial intelligence, inexpensive space travel, clean and abundant energy, and environmental restoration; a technology so portable that everyone can reap its benefits; a technology so fundamental that it will radically change our economic and political systems; a technology so imminent that most of us will see its impact within our lifetimes. Such is the promise of Nanotechnology.” Kai Wu What is Nanotechnology.... [tags: Nanotechnology]
2262 words (6.5 pages)
- Nanotechnology Before I can really address this topic properly I have to answer “What is Nanotechnology and why the hype?” Currently the term nano has been thrown around a lot in recent years. Mostly this is the desire of researchers to grab the research money that is out there and using buzz words do help turn heads. Nanotechnology is a grab bag of different fields of science. It takes from condensed-matter physics, engineering, molecular biology and large swaths of chemistry. Even the government was convinced by the hype to create The National Nanotechnology Initiative (NNI) is a multi-agency program intended to provide a big funding boost to nanoscience and engineering.... [tags: Science Scientific Nanotechnology Papers]
1773 words (5.1 pages)
- Nanotechnology Nanotechnology is the understanding and controlling of matter at sizes of roughly 1 to 100 nanometers. Using nanoscale science, phenomenal engineering, technological, medical, chemical, and informational feats are possible (1). However, the applications of nanotechnology do not stop there. As a Finance major, I feel it is extremely important to understand the current and immense future economical possibilities this technology presents. Although it will cause a bang in the market, the more important role it plays is the facilitation and miniaturization of the tasks we perform daily and rely on to survive. Nanotechnology... [tags: Technology Nanotechnology]
1036 words (3 pages)