Feline coronavirus (FCoV) is known to be prevalent and common infection in cat populations, with particularly high prevalence in catteries and multiple-cat households [1, 2, 3]. The genome is characterized as an RNA virus under the family Coronaviridae, order Nidovirales [3, 4]. It was first recognized in 1950s as a specific disease of cats  and its first occurrence in Malaysia in 1981 . Two pathotypes of coronaviruses are described in cats; feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). These FCoVs are spread world-wide and infect cats and other members of the family Felidae. FECV is the common form of FCoV, which causes from asymptomatic infection to severe enteritis and can be transmitted in nature between cat populations [3, 7]. Unlike FECV, the FIP is an immune-mediated progressive polyserositis and pyogranulomatosis. It is the most important cause of death of infectious origin in cats worldwide, affecting both domestic and wild felids [5, 7].
Circulating antibodies against FCoV are found in 90-100% of the cats living in catteries or multiple-cat households and up to 50% of solitary cats house; however, only 1–5% of the seropositive cats eventually come down with FIP [8, 9, 10].
Both FECV and FIPV are further subdivided into two different serotypes, I and II, based upon their, antigenic relationship to canine coronavirus (CCV), neutralization reactivity with S-protein-specific mAbs, sequence analysis of the S protein gene and growth ability in vitro. While serotype I grows poorly in cell cultures, serotype II can grow well in many different cell line [11, 12, 13]. The FECV is more tropic for mature apical epithelium of the bowel whereas FIPV infects blood monocytes a...
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...each. Pelleted samples were initially infiltrated with a 50:50 mixture of resin and acetone and subsequently embedded in resin and polymerized in an oven at 60°C overnight (Memmert, Germany). Ultrathin sections on a copper grid were stained with uranyl acetate and lead citrate . The preparations were examined under TEM.
25. Hayat M A (1986) Basic techniques for transmission electron microscopy. Academic Press inc, Newyork. Pp 56-125.
26. Reynolds E S (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 4, 208-212.
27. Weiss RC and Scott FW (1981) Pathogenesis of feline infectious peritonitis: Nature and development of viremia. Am J Vet Res .42, 382-390.
28. Ward J M (1970) Morphogenesis of a virus in cats with experimental feline infectious peritonitis. Virology. 41, 191-194
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