The Importance Of Zinc

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Zinc is an essential trace element for many living organisms. While this can be said about other essential metals, zinc is unique in its physiochemical properties that give it the ability to interact with donor groups of different ligands, resulting in a broad range of stability constants and diversity of the biological functions and processes that zinc is involved in. It was discovered and recognized as a new metal in the eightieth century, While its biological essentiality was found by Raulin for the growth of Aspergillus niger In 1869 [1]. In 1933 Zinc was found essential for the growth of animals while studying its effect on rats. [2]
The importance of zinc for the human body was not known till the mid-60s when Prasad AS discovered zinc
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Mainly this deficiency occurs due to insufficient zinc intake or insufficient absorption from food.[7]

2. Physiological roles of zinc:
Zinc is present in all body tissues and fluids, with a total content ranging from (1.5-2.5gm) [8]. It has a key role in the normal physiology of the human body with various functions as a catalytic and structural component of various proteins[9]. Furthermore, It works as an antioxidant, anti-inflammatory agent and signaling mediator contributing to its vital roles in immunity, wound healing, and tissue repair.[10, 11]
2.1. Zinc in proteins:
Zinc is a cofactor in over 300 metalloproteins including RNA and DNA polymerase, thus indispensable part for protein synthesis, DNA synthesis, and cell growth. Zinc proteins are estimated to be around about 10% of the human proteome.[12] The essentiality of zinc in the formation of enzymes was first demonstrated in 1940 when zinc was found in the composition of the carbon anhydrase enzyme [13], ever since studies have been carried out on different classes of enzymes and proteins to understand the role of zinc in composition and functions of

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