Therefore, wherever malaria occurs there is sickle cell disease. It is also believed that people who carry the sickle cell trait are less likely to have severe forms of malaria. It is estimated that sickle cell disease will affect 90,000 to 100,000 American. Sickle cell disease affects a large percentage of people in Central America as well as significant numbers in South America such as Brazil, and the Caribbean. Sickle cell disease is the most frequently occurring genetic disease on the earth.
This treatment may even offer a cure for only a small number of people and the risk is far too great. Gene Therapy is another new treatment. Gene therapy is being studied as a possible treatment for sickle cell anemia. Researchers want to know whether a normal gene can be put into the bone marrow stem cells of a person who has sickle cell anemia. This would cause the body to make normal red blood cells.
The problem is that sickle cell anemia affects about 72,000 Americans in the United States. Sickle cell anemia is an inherited disease in which the body is unable to produce normal hemoglobin, an iron-containing protein. Abnormal hemoglobin can morph cells that can become lodged in narrow blood vessels, blocking oxygen from reaching organs and tissues. The effects of sickle cell anemia are bouts of extreme pain, infectious, fever, jaundice, stroke, slow growth, organ, and failure. Sickle cell anemia hurts many people today in fact it hurts about 72,000 Americans.
The sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell have red blood cells that have mostly hemoglobin's, Sometimes these red blood cells become sickle-shaped or crescent shaped and have trouble going through small blood vessels. When sickle-shaped cells block small blood vessels, less blood can get to that part of the body. Tissue that does not get a normal blood flow eventually becomes damaged.This is what causes the problems of sickle cell disease.As to this day there is really no cure for sickle cell disease.Red blood cells take oxygen from the air we breathe into our lungs to all parts of the body. Oxygen is carried in red blood cells by a substance called hemoglobin(Hemoglobin – is the main substance of the red blood cell.
Leukemia also causes anemia. Anemia is a disease in which the body makes less blood cells. This happens because the leukemic cells crowd the system. Leukemia also causes excessive bleeding. This happens because the amount of platelets will decrease and clotting will not occur, Researchers think a change in genetic structure causes leukemia.
Abstract Sickle Cell Anemia is a hereditary disease that changes the smallest and most important components of the body. A gene causes the bone marrow in the body to make sickled shapes, when this happens; it causes the red blood cell to die faster. This is what causes Hemolytic Anemia. Older children and adults with sickle cell disease may experience a few complications, or have a pattern of ongoing problems that shorten their lives. The most common and serious complications of sickle cell disease are anemia, pain, fatigue, and organ failure.
These drugs have also decreased the need for hospitalization. Scientists are also testing these and other drugs to see if they work for kids and teens. In rare cases, people with severe sickle cell anemia may be given a bone marrow transplant to help them produce healthy hemoglobin. Scientists are also studying gene therapy as a good treatment for sickle cell anemia. One day, doctors may be able to stop the disease by changing or replacing the abnormal gene that causes sickle cell anemia.
Meanwhile, the bone marrow, where red blood cells are made, pitches in by making more cells. It can't keep up with the destruction, though, so the total number of red blood cells drops to a low level and the body becomes anemic. ("Anemic" is the medical word for having a low number of red blood cells.) What is sickle cell anemia? Sickle cell anemia is an inherited disease of red blood cells.
Currently, there are no cures for sickle cell anemia, but there are treatments that may assist with the pain and avoid further complications. Beside the fact that sickle cell anemia is inherited, it is actually caused by a mutation in one of your genes. This mutation tells your body to make hemoglobin, an iron rich compound that gives your blood color. Hemoglobin is what allows blood red cells to carry oxygen from your lungs to the rest of your body. In sickle cell anemia, it causes the hemoglobin to become abnormal resulting in the shaping of your blood cells to change.
Background Info? Bone marrow transplantation restores stem cells that were destroyed by high doses of chemotherapy and/or radiation therapy. After being treated with high-dose anticancer drugs and/or radiation, the patient receives the harvested stem cells, which travel to the bone marrow and begin to produce new blood cells. Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic or blood-forming stem cells.