Pharmacokinetic and Pharmacodynamic Interaction of aqueous extract of Cassia auriculata L. leaves and Metformin in rats.

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1. Introduction Cassia auriculata L. (CA) is profoundly used as a tonic, astringent, anti-diabetic, conjunctivitis and opthalmia in Ayurvedic medicine (Subhadradevi et al., 2011). It is one of the principle constituent of Avaarai panchaga chooranam; an Indian herbal formulation used in the treatment of diabetes to control the blood sugar level (Berman et al., 2001). Cassia species, are rich sources of polyphenols, anthraquinone derviatives, flavanoids, polysaccrides, saponins, tannins and steroids (Singh et al., 1980; Yen et al., 1998; Ayo et al., 2004), flavanoids, sterols/terpenoids and phenolic acids are known to be antidiabetic bioactive principles. Flavanoids are known to regenerate the damaged β cells in alloxan induced diabetic rats (Yasir M et al., 2012). Diabetes mellitus, caused by an absolute or relative deficiency of insulin or its function, lead to number of complications, it is emerging as the factor responsible for chronic disability and even death. Most of the secondary failures are observed with monotherapy and devastating long term consequence of poor glycemic control. Also it is always beneficial to switch over the patient on combination therapy. A reasonable goal of treatment is to maintain good glycemic control through combination therapy to keep the blood glucose level to near normal to particular patient. (Kuchake V. G, et al. 2009). The first choice of biguanide for the recently diagnosed diabetic patients is MT (MT). It acts by reducing hepatic glucose production and improving insulin sensitivity. Studies have suggested that administration of MT with phytoconstituents / herbal products presumably enhanced therapeutic effects (Dey et al., 2002), however sufficient data is lacking with respect to their p... ... middle of paper ... ...rmTech Research. 1 (1), 50-61. Mukherjee, et al. (2006) Lead from Indian medicinal plants with hypoglycemic potentials. Journal of Ethanopharmacology, 106 p.1-28. Singh J, et al. (1980). Anthraquinone and flavonoids of Cassia laevigata roots. Phytochemistry. 19 (6), 1253-1254. Subhadradevi V, et al. (2011). Antimicrobial Activity of Leaves and Flowers of Cassia auriculata linn. Bangladesh Journal of Scientific and Industrial Research. 46 (4), 513-518. Yasir M, etal, (2012). Hypoglycemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dunal and Acacia arabica Lamk in Normal and Alloxan Induced Diabetic Rats.Pharmacognosy Communications. 2 (2), 61-66. Yen GC, etal. (1998). Extraction and Identification of an Antioxidative Component from Jue Ming Zi (Cassia tora L.). Journal of Agriculture and food chemistry. 46 (3), 820-824.

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