Both types of hemophilia have the same symptoms and risk factors; it is simply based off of which blood-clotting factor is missing. Risk Factors The most common risk factor associated with hemophilia is a high risk of prolonged or excessive bleeding. Deep internal bleeding and bleeding into joints are other risk factors of hemophilia. (Mayo Clinic, 2011). rthritis and arthropathy can also occur as a result of bleeding in the joints.
The greatest concern for both types is deep internal bleeding and bleeding into joints. Hemophilia is a life long disease, but with proper treatment and self-care, most people maintain an active productive lifestyle. Causes Hemophillia is caused by a defect in one of the genes that determines how the body makes blood clotting factor VIII or IX. These genes are located on the X chromosomes. Females have two X chromosomes, while males have one X and one Y.
Small cuts and bruises are not usually life threatening but any serious injury or invasive surgery has the potential to be life threatening because of this disorder. Hemophilia can also cause internal bleeding, which can cause organ or tissue damage. This can be life threatening as well. There are two types of Hemophilia. Hemophilia A is due to the individual producing low levels of clotting factor VIII while Hemophilia B is due to the individual producing low levels of clotting factor IX.
The bursa are found mostly in joints between skin and bone or bone and tendons. When you irritate these lubricating sacs, the bursae fill with fluid and become irritated and inflamed. This inflammation causes severe pain with movement of the joint, often limiting the movement of the affected area. Bursitis commonly strikes in the shoulders, elbows, knees, pelvis, hips or Achilles tendons. Bursitis can affect nearly anyone for any number of reasons.
In mother to child transmission, HIV can be acquired in utero when the virus crosses the placental barrier, during delivery, or through breastfeeding (2). The development of Triple Action Therapy or Highly Active Antiretroviral Therapy (HAART) happened in the late 1990’s (3,4). It uses multiple Antiretrovirals (ARVs) that individually target three steps in HIV replication (entry inhibitors, fusion inhibitors, reverse transcriptase inhibitors, integrase inhibitors, protease inhibitors, and multi-class combination products) (2). The concept was first introduced in 1996, during the international conference on AIDS in Vancouver, British Columbia. This development of a multi-drug therapy was able to significantly reduce the progression of the virus as well as decrease the death rate (4).
Normal levels of the factor proteins measured in the lab range approximately 50%-150%. Severe Hemophiliacs have 1%-5% of the specific protein. Mild Hemophiliacs have >5%-49% of the specific protein. As expected, those with the severe hemophilia may have spontaneous bleeding as a well as bleeding with minor injuries and trauma. Those with moderate hemophilia will have bleeding with injuries or trauma but not likely to have spontaneous bleeding.
(6)(13) If they produce 2% to 5% of the normal level they have moderate Hemophilia, someone who produces 6% to 50% of the normal level they have mild hemophilia. (6)(13) If you have mild hemophilia u might bleed excessively only once in a while, while someone with severe hemophilia is more prone to bleeding excessively often. (6)(14) Most people with hemophilia discover the condition at a very young age. (6) But, sometimes a person with very mild hemophilia will not discover it until they have a minor surgery; it’s discovered in the blood tests that the doctors perform before the surgery. (6) Hemophilia is caused by a defective gene on the X chromosome.
Hemophilia is a genetic bleeding disorder. People who have hemophilia have a deficiency or an absence of a coagulation protein. A blood clotting factor is deficient or absent. Bleeding is most often into joints, such as the knee, elbow, or ankle, but bleeding can occur anywhere in the body. People with hemophilia bleed longer, not faster.
Type B is when the Hemophiliac lacks blood clotting factor nine (Medicalnewtoday.com). A Hemophiliac is the name given to people with this disorder. Type A takes place in about one in every 10,000 child births and Type B is one in every 50,000 child births. This disorder originates hereditarily from the mother to child, mostly from mother to baby boy. It is induced by another disorder where the baby has a deformity in one of the clotting factors genes which sticks to the X chromosome.