Fluidised Bed Granulation Essay

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• This is where the particles are set in motion for example, a mixer or fluidised bed, and a liquid is usually sprayed to wet the surface of the particles. In addition a solid binder is sometimes used. Agglomerates are formed by particles colliding and sticking to each other. The granules formed by liquid addition are usually not the end product in a granulation process.

• Three categories of granulator are used commonly: tumbling, mixers (convective and high shear) and fluid bed granulators. One method commonly used in the pharmaceutical industry, to transform fine heterogeneous powders into a homogeneous blend of granules with bigger size and density to improve flow and compact ability for tableting operation, is the high shear wet granulation process.

Fluidised bed granulation
Fluidised bed granulation is a process by which granules are produced in a single piece of equipment by spraying a binder solution onto a fluidised powder bed. The fluid bed granulation process has received considerable attention …show more content…

When using the gas atomising nozzle, the binder solution is atomised by compressed air. It is the most commonly used nozzle for fluid bed granulation. Different designs can be selected for the main parts of the granulator and this depends on factors such asplag: processing option, mode of operation (batch or continuous), use of equipment and principle of processing. Granulation in a fluidised bed granulator is achieved by suspending the powder in the air of the fluidised bed and then spraying the binder solution from nozzles that are either positioned above or below the powder depending on the type of granulator. However, this type of granulator comes with both advantages and disadvantages which can be seen in the table on the next

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