Fact or Myth: Pyrroloquinoline Quinone (PQQ) The hype: A quick Google search of PQQ easily returns over 2.3 million results. When you start perusing the top Google hits, one can quickly assume that PQQ is the new wonder supplement. The claims, from what appears to be high quality web pages for brick and mortar type health clinics are; Increase mitochondrial density to give you more energy, reduce inflammation, boost metabolism, combat oxidative stress, improve fertility, improve learning and memory ability, prevents the development of osteoarthritis, protects nerve cells from the damaging effects of Alzheimer’s disease, improved mental function, and lowers LDL cholesterol levels (Asprey) (Murray, N.D.). We could go on and on. Does this smack of slightly, “too good to be true”? Pyrroloquinoline Quinone (Figure 1, PQQ), is not new. It was discovered in 1964 by J.G. Hauge, in hopes that PQQ would be a new vitamin compound. However, he discovered it was a redox cofactor, a non-protein chemical compound capable of both reducing and oxidizing, it is not a pure antioxidant. Originally synthesized from bacteria as a dehydrogenase (an enzyme that catalyzes the removal of hydrogen), from the bacteria’s glucose. This compound is found in most living cells, plant and animal, including human. However, only a few organisms have been reported to be capable of biosynthesizing (creating new) PQQ, mostly in bacteria. Its chemical formula is, C14H6N2O8. PQQ is not currently classified as a vitamin, although it has been shown to be an important nutrient in mammals. Free PQQ is widely found in most dietary sources; natural sources as well as man-made products. The highest naturally occurring concentrations are found in parsley (34.2 ng/g), and f... ... middle of paper ... ...ommend PQQ supplementation enthusiastically. Unfortunately, I don’t believe there are enough human trials to prove definitive effectiveness of Pyrroloquinoline Quinone. “Finally, strong indications exist to assume that this is not the end of the story since other Quinone cofactors seem awaiting their discovery.” (Duine) Anecdotally, I have been taking a 20mg PQQ supplement, along with CoQ10, and a multivitamin, daily for the past 60 days. I have not personally noticed any effect or side-effect. I believe the researchers show the cardio and neuroprotective benefits of PQQ are beneficial. Also, the amount of published research work on PQQ is overwhelming for a quickie 4-5-page paper. I apologize in advance, for most of the scientific papers referred to are only from abstract sources. To gain access to full-text versions would be financially offensive to my wallet.
...is still research to be done, but for now it is up to the individual to decide if he or she is healthy enough to take these products safely or if it is even worth taking,given the long-term effects.
PhenQ is a complete weight loss supplement for both men and women. It contains the current most cutting-edge patented formula in a-Lacys Reset and has been produced to lessen the user’s fat storage and increase the muscle definition. It’s one serious task to shred fat and assemble muscle in the meantime so if a supplement can truly offer you some assistance with managing to succeed then it is worth a thought.
Brownstein, Joseph. “Some common vitamin supplements could increase death risk, study finds.” 10 October 2011. Vitals on mnsbc.com. Web. 11 January 2012. http://vitals.msnbc.msn.com/_news
(13) Pazirandeh S. Overview of vitamin K. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed 27th April 2014)
...s little information about the possible benefits of the study or the side effects. The side effects proved to be significant (gastrointestinal complains, headache, and an elevation of alanine aminotransferase), while the benefits were minimal. This situation emphasizes the need for a balanced approach when it comes to drug clinical trials.
The pseudoscientific claim that will be discussed is a claim made by Applied Nutritional Research, a company based out of Colorado, which claims that it is a distributor of nutritional health products.
When it comes to supplements, I feel that there is a lot of misleading health benefits from actually taking them. As I learned from monitoring my own nutrient intake, our diet sometimes is lacking of important vitamins and minerals. There are so many supplements that promise curse and longevity by taking their pill, however, their claims have not been to my standards scientifically supported. In contrast, vaccines still have a negative stigma or attitude concerning side-effects which sway parents away from having their children receive these lifesaving vaccines. There is volumes of clinical research that supports the benefits of vaccines against deadly diseases and dispels most concerns over any serious
We, as consumers, are always trying to find new products to buy in which to improve ourselves. In modern-day American culture, improving oneself has become synonymous with feeling younger and healthier. Gingko biloba extract is one of the popular herbal supplements being marketed to mainstream consumers as a "smart" and "anti-aging" drug (http://www.stevemorow.com/food.htm) which will work to help to increase their overall brain functioning in the normal population, as well as, those who suffer from mental impairment due to aging. Gingko biloba extract has also been labeled an anti-aging drug due to its antioxidant properties, its supposed free radical scavenger properties, as well as its reported increases in people’s overall mental functioning. You see advertisements for it on television, as well as, the Internet making a large number of different kinds of claims of Gingko biloba’s benefits. The claimed benefits range from increasing overall brain functioning in normal people to people with mental impairment, to being a mood enhancer (http://www.televar.com/alpha/biloba.html), to helping with such slight conditions as cough and asthma, to helping increase circulation in patients suffering from painful vascular diseases to actually having "slimming" applications (http://www.mmpinc.com/WHATS.HTM). If all these claims are true, then Gingko biloba extract sounds like a "mulit-cure"drug for the entire population. This paper will attempt to reduce the confusion associated with the large number of claimed benefits of taking Gingko biloba by explaining what the research literature has to back up these claims. I had a hard time myself keeping track of all the reported claims. At this time, Gingko bil...
Pauly, S. (2011, February). News from ABC: changes and challenges. Analytical & Bioanalytical Chemistry. pp. 1003-1004. doi:10.1007/s00216-010-4459-0.
(https://www.truthinadvertising.org/about/) Back in 2014, TINA.org approached consumers to participate in Coca-Cola’s preparatory settlement over deceptive labelling and advertising of its Glacéau Vitaminwater beverages. Glacéau vitaminwater beverages make unjustified health claims, such as it could promote healthy joints, lessen the risk of eye disease as well as to support immune functions. (http://www.businessinsider.sg/coca-cola-glacau-vitaminwater-misleading-advertising-lawsuit-2014-10/?r=US&IR=T#.VoZjCjZn9g1) The nutrition content of vitaminwater is mainly sugar-water with a small amount of synthetic vitamins.
The second stage of the discovery process is a drug discovery itself. Its main goal is to find a lead compound. Lead molecule is a promising compound that has a potential to become drug. There are several ways to find the lead compound, they include nature, de novo, high- throughput screening and biotechnological methods. For many centuries drug...
While alternative medicine can help cure many things that modern medicine overlooks, it does not produce miracles. With new medical advances each year, we can cure more and more diseases, illness, and injuries. Unfortunately, just because we can create a new treatment that can cure an illness or injury, does not mean that the treatment will be perfect. There are several side effects or long-term problems that we have yet to notice. No treatment is perfect, which is why millions of dollars and hundreds of hours are spent each year trying to better today’s modern
Pyrrole has been a molecule of great interest due to its heterocyclic aromatic properties. The lone pair on the nitrogen is delocalised within the ring, causing the heterocycle to be electron-rich . This causes the ring to become increasingly nucleophilic, and therefore makes it susceptible to attack from electrophiles . The addition of these new substitutions makes more important molecules , which have a huge contribution to not only the chemical industry, but also the biological. 1 Substituted pyrrole molecules are fantastic precursors to make complex molecules, such as medicines, agrochemicals and dyes. Indole, an important benzo-pyrrole, is the basis of the important protein, tryptophan and has functions as a neurotransmitter in the brain. The neurotransmitter, serotonin, is important in making modern drugs such as sumatriptan which treats migraines.2
Health claims are booming in today’s world. Many of these consumers are being misled by advertising and believe that their choice will benefit their health. Although herbal medicines have been in existence throughout human evolution, I have chosen to take a deeper look into these health practices. I’m curious if this is just another health claim or if there are actual benefits to taking these medicines.