rat ileal smooth muscles express five isoforms of muscarinic acetylcholine receptor MAchR (M1-M5)(Yuan et al., 2011), and seven classes of 5-hydroxytryptamine (5-HT, serotonin) receptors (5-HT1-5-HT7)(Briejer et al., 1997). These receptors are major drug targets and belong to the family of G protein-coupled receptor (GPCR) consisting of seven transmembrane spanning domains (Hannon & Hoyer, 2008; Yuan et al., 2011). Both MAchR and 5-HT receptors are essential in the regulations of smooth muscle
include Scopoderm and Transderm-V. The medication works as an antagonist at muscarinic acetylcholine receptors by blocking the acetylcholine-mediated nerve impulses that travel to the inner ear. The inner ear is where the sense of balance is regulated in humans. Acetylcholine (Ach) is a major transmitter found in the autonomic ganglia that allows neurons to communicate for sensory input and muscle control. Muscarinic receptors are vital in the control of the central nervous system (CNS) and also parasympathetic
2005). Just like teratogen, stress can affect the fetus development with mild or serious consequences during childhood and adulthood. Both teratogen in this case smoking and stress can adversely affect the fetus by producing Nicotinic Acetylcholine receptors and cortisol respectively, which have a great impact on the prenatal and postnatal development. Proteins are building the human body. They trigger chemical reactions throughout the body (Berk, 2010). They are produced within the cell, and
It is a nagging voice behind every smoker’s head. It tempts every user that tries to quit into using it “one more time” before giving it up. With the chemical formula of C10H14N2, this alkaloid is better known as nicotine. Being the major chemical in tobacco, nicotine is the reason that users often get addicted to tobacco products such as cigarettes, cigars and snuff. It is also because of this addiction that would indirectly causes over 400,000 deaths annually in the United States while costing
disorder the immune system attacks parts of the body. The part of the body that is attacked by the circulation of antibodies, is the muscular system, and in certain receptors for acetylcholine on muscle cells at the neuromuscular junctions. An overview of the disease: MG patients have only one-third of the normal numbers of acetylcholine receptors which causes weak and easily fatigued muscles. The muscles under voluntary control are affected. The heart muscles, which are under involuntary control, are not
that blocks the response to an agonist drug. An agonist is a drug that elicits a response when it is administered to a tissue. The aim of the investigation was to compare the actions that the agonist, carbachol and antagonist, atropine has at muscarinic receptors on rat ileum. A concentration-response curve was determined with a cumulative concentration of agonist, expressed as a sigmoidal curve with an sub-maximal response (EC70) value of 5.5x10-6 M. As the agonist concentration increased to 5x10-6
neurotransmitters on the heart’s rate and contractility. Prior to conducting the experiment, we hypothesized that the more the heart muscle stretches, the greater the force of contraction will be and that if a neurotransmitter can act on a muscarinic and nicotinic receptor without an antagonist present, the agonist will produce a parasympathetic (decrease in heart rate) and sympathetic response (increase in heart rate and contractility) respectably. After conducting the experiment, we can say with certainty
Depression is one of the most widespread mental disorders globally, affecting more that 350 million people of all ages. It is characterized by disturbed sleep, loss of appetite, sadness, poor concentration and feelings of guilt. There are various types of depression which are long lasting, and other types which are constantly reoccurring (World Health Organisation , 2012). Severe symptoms of depression that inhibit the ability to work, sleep and eat is categorised as major depression, this form of
1. The three differences between arteries and veins are which veins they have few layers of smooth muscles and connective tissue unlike arteries which have many layers of smooth muscle tissues. The difference in the two is also veins have very little elastic as well as a wide lumen and arteries have several layers elastic and a regular lumen. Last but not least veins carry oxygenated poor blood to the heart and arteries carry oxygenated blood away from the heart. 2. Blood pressure, flow and resistance
Reserpine Reserpine reduces the noradrenaline supplies in peripheral organs. It also reduces the cardiovascular response to sympathomimetic amines. When reserpine is taken the postganglionic sympathetic nerves are not able to transfer impulses through the neuroeffector junctions. Reserpine prevents the acceptance mechanism of amines for the storage of granules for sympathetic tissues. Preventing dopamine uptake into granules, allows reserpine to hinder the formation of noradrenaline. In small dosages
beta-adrenergic receptor, it reacts by causing the increase in vascular constriction and decreasing vasodilation (Inc.). Also, adrenalin is a hormone that is secreted in the body and involves the fight or flight response, decreasing heart rate, and increasing calcium channels to open. Nodal cells will reach threshold more quickly and will increase the firing rate of the SA node. The faster stimulation of the heart is by the delay in the AV nodes that causes a decrease. Next, is ACh acetylcholine its mechanism
“All things are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy” (Jickells & Negrusz, 2012). In today’s society, the use and abuse of drugs can be seen in all populations and generations. The desire to obtain euphoria is a driving force in the abuse of drugs. The most prevalent drugs are plant based or synthetic counterparts; cannabis, cocaine, diamorphine, or heroin. As drugs become main stream, the Drug Enforcement Administration (DEA) is set with
INTRODUCTION Asthma is a common chronic disease worldwide and affects approximately 24 million persons in the United States (Morris, 2015). It is the most common chronic disease in childhood, affecting an estimated 7 million children. It is one of the most common reasons for visits in ambulatory settings and accounts for 16.5 million office visits each year (Buttaro, Trybulski, Bailey, & Sandberg-Cook, 2013, p. 408). Improperly managed and poor asthma control can lead to frequent emergency visits
commissioner of the FDA, launched an attack on tobacco companies, claiming they deliberately increased nicotine levels in cigarettes. Nicotine has been shown in various experiments to induce tolerance in smokers by its effects on the CNS and dopaminergic receptors. David Kessler believes nicotine to be addictive and desires the FDA to regulate nicotine as any drug such as cocaine. If the agency can prove that nicotine is addictive and that the manufacturers of tobacco products have control over the levels
(A)Wound healing is a biological process occurring in the human body. In this lecture we had discussed about both acute and chronic wounds. An acute wound is an injury to the skin that occurs suddenly rather than over time. It heals at a predictable and expected rate according to the normal wound healing process. The chronic wounds do not heal in an orderly set of stages and in a predictable amount of time the way most wounds do. The normal wound healing process mainly consists of four main stages
Botulism is a rare but very serious paralytic illness that is caused by the botulinum toxin that is produced by the bacterium Clostridium botulinum. C. botulinum is a gram positive, anaerobic, spore forming bacterium that is naturally occurring in soil. Botulism dates back to the eighteenth century when the first food borne botulism was documented. During this time many people were doing home fermented sausages and this was thought to be the cause of botulism. This is how the toxin got its name