Cancer is one of the leading causes of death worldwide as it can develop in almost any organ or tissue. Significant advances in understanding the cellular basis of cancer and the underlying biological mechanisms of tumour has been vastly improved in the recent years (Jiang et al. 1994). Cancer is a genetic disease which requires series of mutation during cell division to develop, it has characteristics which can be associated with their ability to grow and divide abnormal cells uncontrollable while in the mean time invade and cause nearby blood vessels to serve its need. Even though many people are affected by cancer today, the abilities which cancer cells own make it hard to find single effective treatment for cancer. The focus of research now lies on developing drugs which target cancer cells in the hope to cure cancer once and for all.
There have been extraordinary progresses in identifying cancer at the cellular level and the question of how cancer cells develop are no longer a secret. Although there are many different types of cancer and almost every tissue can turn into malignancies, the basic processes of how cancer arises are very similar. While normal body cells follow the orderly path of cell cycle and only reproduce when instructed to do so, cancer cells violate the schedule and ignore instructions, it fails to follow the orderly enzymatic reaction which is responsible for the deletion of cells with damaged DNA (Kerr et al. 1994). Cancer cells enter cell cycle repeatedly until it will eventually disrupt the function of tissues and organs that are essential to the organism (Weinberg 1996). Not all types of cancer are fatal, benign cancer is a type of cancer which stays in one location only, in another word it will not m...
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...r is hard to cure due to its ability to metastasis and avoid apoptosis due to mutation occurs in the genes during mitosis, especially on oncogen and tumour suppressor gene. Oncogen contribute to cancer cells by encouraging cells to grow and divide excessively while tumour suppressor genes inhibit apoptosis. As all cells on Earth require oxygen, nutrients and the ability to remove waste products to survive and develop, it seems possible to develop anti-cancer drugs which will target at those blood vessels which supply nutrients to tumour cells. Even though this method is providing some promising results, there is no significant improvement in the overall survival of the organism in the long term. Nevertheless, the understanding of cellular basis of cancer cells gain from numerous researches have certainly help in developing new and effective treatment for cancer.
The cancer stem cell theory hypothesizes that tumors or cancers arise from mutations or epigenetic changes in normal stem cells. These mutated or genetically altered stem cells possess the properties of the normal stem cells such as the ability to self-renew, differentiate into any type of body cell, and resist apoptosis. Hence, the cancer stem cells (CSC) are named so. It is also suggested that because of the above-mentioned properties of the cancer stem cells, the current anti-cancer therapies are not entirely successful (Gil et al, 2008). Despite surgery and other therapies, even if very few of these cancer stem cells survive, they can continue to act as a source for more tumors, even though the therapies eliminate all visible signs of cancer.
Chemotherapy is the treatment of a tumor with chemical agents to reduce mass or eradicate a tumor completely. There are certain mechanisms by which chemotherapy inhibits cancer. The first mechanism is cell death by cytotoxicity. Some chemical agents in certain amounts are toxic to cells. The cells die due to the toxic...
..., while a cell undergoes cell cycle, when a cell comes in contact with another cell, it stops reproducing. However, cancer cells continue to duplicate repeatedly until there is a mass of cells or a tumor to form (see figure 9). Lastly, in cell division when there is a mutation or abnormality in the DNA, a normal cell stops dividing. However, a cancerous cell will continue to duplicate and form mutations (“Cell Biology and Cancer”). Also, cancer cells are harmful because they grow and duplicate with complete disregard to the functions and limitations of the body (see figure 10). Also, cancerous cells have the ability to spread through metastasis throughout parts of the body through the bloodstream. In terms of similar behavior to that of normal cells, cancerous cells also duplicate, but at a very different rate ("Cancer Cells vs. Normal Cells: What's Different?").
Cancer starts when certain cells in the body are mutated or changed and begin to divide. Cancerous cells grow differently than normal cells, instead of progressing through the normal cell lifecycle, cancer cells continue to grow and create more abnormal cells. A specific trait of cancer cells is that they have the ability to infiltrate and grow into surrounding tissues, developing out of control and causing serious damage to the host (Vincent, 2008). Cells become cance...
Smoking is the most preventable cause of death in our society. During 1995, approximately 2.1 million people in developed countries died as a result of smoking. One tobacco use is responsible for nearly one in five deaths in the United States. Lung Cancer mortality are about 23 times higher for current male smokers and 13 times higher for current female smokers compared to a lifelong never-smoker.
Question: A patient with terminal lung cancer tells you, "I want to stop the chemo; my life is good and I want to enjoy what time I have left." How might each of the human dimensions influence this decision? What other factors can influence health decisions?
The cell cycle is the process by which cells progress and divide. In normal cells, the cell cycle is controlled by a complex series of signaling pathways by which a cell grows, replicates it’s DNA and divides, these are called proto-oncogenes. A proto-oncogene is a normal gene that could become an oncogene due to mutations. This process has mechanisms to ensure that errors are corrected, if they are not, the cells commit suicide (apoptosis). This process is tightly regulated by the genes within a cell’s nucleus. In cancer, as a result of genetic mutations, this process malfunctions, resulting in uncontrolled cell proliferation. Mutations in proto-oncogene or in a tumour suppressor gene allow a cancerous cell to grow and divide without the normal control imposed by the cell cycle. A change in the DNA sequence of the proto-oncogene gives rise to an oncogene, which
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...
Healthy cells grow and divide in a way to keep your body functioning properly. But when a cell is damaged and becomes cancerous, cells continue to divide, even when new cells aren't...
Cancer of the lung was nearly nonexistent in the early 1900’s. By the middle of the 20th century an epidemic became apparent throughout the United States and the rest of the world. It is primarily correlated with the widespread abundance of cigarette smoking in the world. The tobacco industry has multiplied its production immediately prior to World War I. There was a typical 20 to 30 year lagging period between the initiation of cigarette smoking and the actual tumor formation in the lungs. Lung cancer is the cancer that originates in the tissues of the lungs. It occurs when cells in the lung start to grow rapidly in an uncontrolled manner. Lung cancer can start anywhere in the lungs and affect any part of the respiratory system. Most of all lung cancer cases start in the lining of the bronchi (health-cares.net, 2005). It is the leading cause of all cancer deaths in the world. During this time the tobacco companies would continue to say that cigarette smoking was not addictive and did not cause any type of cancer. Even with all evidence in the world today about tobacco causing cancer, Tobacco companies still remain the most profitable business in the world. Lung cancer is very common in both women and men. Women account for about 40 percent of the lung cancer cases in the world. Women who smoke are more than twice as likely to develop lung cancer as those of men who smoke (Tavor, 2005).
Most parents remembered hearing about the importance of protecting their children from the sun, yet children are still playing in the sun without sunscreen or protective clothing. Many people these days are not taking skin cancer seriously after knowing its significance. Skin cancer has been a growing problem in the United States and millions of people have suffered from it every year. The three most common skin cancers are Melanoma, Basal cell, and Squamous cell, which can cause bumps, sores, growths, etc. Skin cancer is a deadly disease with many causes, but the advantage is that it can be prevented.
People can lower their risk of developing colorectal cancer by managing the risk factors that they can control, such as diet and physical activity. It is important to eat plenty of fruits, vegetables, and whole grain foods and to limit intake of high-fat foods. Physical activity is another area that people can control. Even small amounts of exercise on a regular basis can be helpful, at least 30 minutes of physical activity on most days. Also, achieving and maintaining a healthy weight.
The East Pennsboro elementary school raised money for a statue at a local park. The statue was a ring of children that were holding hands. There was one child missing; the link was broken. The statue was dedicated to East Pennsboro students that did not make it to their graduation. My sophomore year of high school inspired this piece of artwork.
The American Cancer Society publishes current advances made in cancer research on their website. Many of the exciting discoveries about how best to treat the disease focus on the genetic aspects associated with certain types of cancer. In addition, treatments aimed at genetic solutions to cancer may be more effective and may cause fewer adverse side effects than traditional cancer treatments (American Can...
For years people have been looking for a cure for the devastating disease of cancer. Cancer is the third highest killer in the US with over 2,500,000 victims per year. Oncologists and scientists around the country are researching all forms of cancer in an effort to understand, treat, and ultimately defeat this disease. Already there have been numerous advances in the field, such as chemotherapy and gene therapy. One advance has been the use of a cell process known as apoptosis. By harnessing this normal cell process, scientists hope to have found an effective way to combat cancer.