The Disease Of Alzheimer 's Disease

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“Alzheimer 's disease is a progressive, degenerative disorder that attacks the brain 's nerve cells, or neurons, resulting in loss of memory, thinking and language skills, and behavioral changes (“About Alzheimers”).” This is a disease that occurs mainly in the elderly, around ages 65 and up. This disease clogs the brain with a plaque like protein called beta amyloid. Also created neurofibrillary tangles that are composed of tau protein and build up in nerve cells. The plaque forms around neurons (“About Alzheimers”). What that does is disrupts the communication between neurons and synapses, eventually alzheimer’s destroys both synapses and neurons. Slowly destroying the brains communication (“Current Alzheimer 's”). The history of alzheimer 's goes back to 1906 when a German doctor named Alois Alzheimer presented his case at a medical meeting. The case was of a fifty one year old woman who suffered a unknown brain disorder. They did an autopsy on this woman and found the plague now known as beta amyloid and neurofibrillary tangles in her brain. They named the disease after the doctor for his findings (“About Alzheimers”). After the discovery of alzheimer 's, not much really came in the way of any sufficient findings. Almost a century after its discovery a neurologist called Warren Strittmatter in 1991 was studying amyloid beta. He was trying to find amyloid binding protein that 's in fluid that buffer the spinal cord and the brain. Upon doing this he stumbled across apolipoprotein E (APOE). Until this point the protein was not considered a factor in the development of alzheimer 's. Two years before a discovery was found that there was a genetic association with the 19th chromosome and alzheimer 's. This is especially important... ... middle of paper ... ...down the process of the destruction of the neurotransmitters that alzheimer 's causes. The second mechanism is called memantine. This regulates the activity of glutamate, an important part of the neurotransmitters that are involved in bother learning and memory. Glutamate attaches to cells and controls the calcium the NMDA receptors give it. Alzheimer 's damages cells and the damaged cells releases the glutamate on the itself. This leads to overexposure of calcium to the cells and can damage the cell. Memantine blocks the NMDA receptors to an extend to help with this problem (“Current Alzheimer 's”). Alzheimer’s is a very serious disease that affects many. There are many causes and signs of getting or having alzheimer 's. While there is drugs to help, there is no true cure. With the continued research and studies, someday there will be a cure to fight this disease.
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