With Alzheimer’s, the amount decrease is extremely significant. The cortex begins to shrivel up which is the part of the brain required for planning, remembering, and thinking. The most noticeable shrinkage occurs in the hippocampus. The hippocampus is responsible for the formation of new memories, it is also located inside the cortex. Upon further inspection under microscope, tissue samples are observed and synapses and nerve cell count is severely decreased.
REST increases in older adults but is lower in victims infected by Alzheimer’s. “Individuals with Alzheimer’s disease, a degenerative brain disorder that involves a decline in memory, have an acetylcholine deficiency” (King, Griguoli & Cherubini, 2012). According to Bruce yankner, a professor of genetics at Harvard Medical School, “it’s an amazing idea that neurons that you’re born with will function for 100 years or more, in a very high-stress situation . . .” Cells made from Acetylcholine are often stored in the spinal cord and the brain, help Alzheimer’s disease by decreasing the effects of memory loss and short attention span.
AD does not have a cure yet, scientists are however trying to find the root of the disease and control its destructive powers. Currently there is no cure for Alzheimer’s, scientists have also tried to increase the time for which the disease can fully take over the nerve cell connections, however that to cannot be achieved present-day, sometimes if the disease is caught early on it can be slowed down, but it is very rare. They are however developing treatments that may help with the symptoms. Out of about 7 billion people in the world, 300 million are American and the Alzheimer's Association states that, “More than 5 million Americans have Alzheimer's disease today” (Stone, “Genetics and Alzheimer's”). Alzheimer's disease is the source of the destruction or decline of brain cells or nerve cells.
Nevertheless, it seems likely that damage to the brain starts a decade or more before problems... ... middle of paper ... ...fficient chemical messenger that enable nerve cells to communicate with each other in the brain, allowing them to perform their jobs such as thinking, learning and remembering. (Alzheimer’s Association, 2014) Although there is no treatment can stop Alzheimer’s disease. However, some drugs such as rivastigmine may help to keep the symptoms from getting worse for a limited time. (MedicinePlus, 2014) Today, Alzheimer's is at the forefront of biomedical research. Researchers are working to uncover as many aspects of Alzheimer's disease Ninety percent of what people know about Alzheimer's has been discovered in the last 15 years.
Progeria is not usually passed down in family. Children with Progeria often suffer from symptoms typically seen in elderly people (Davis1). People inherit the disease only one copy of the LMNA gene is enough to cause the disease because it is an autosomal dominant gene. The Progeria Research Foundation was created in 1999. Progeria does have parallels with normal ageing; at least in one key aspect how out blood vessels deteriorate.
There is currently no cure for this traumatic disease, but current Alzheimer’s disease medications and management strategies may temporarily improve symptoms. This can sometimes help people with Alzheimer’s disease maximize function and maintain independence. There is still no known fact on how the Alzheimer’s disease process begins. They seem to think that the damage to the brain starts a decade or more before problems become evident. During the preclinical stage of Alzheimer’s disease, people are asymptomatic, but unfortunately there are toxic changes taking place in the brain.
This is a normal phenomenon in an aging person. However, many elderly people forget on a much larger scale and eventually lose the ability to care for themselves. Although half of the elderly's population carries these symptoms, their condition is considered abnormal and the leading cause for dementia, otherwise known as Alzheimer's disease. Alzheimer's was named after the German physician Dr. Alois Alzheimer who discovered the disease in 1906 in a middle-aged woman with dementia. After her autopsy, two abnormal brain structures were found that today are fundamental in understanding the progression of Alzheimer's disease.
Approximately 15 percent of people who are over 65 will develop some form of dementia; by the age of 85 that percentage increases by at least 35 percent. Alzheimer's is the most common dementia, nearly four million Americans suffer from it. Alzheimer's is a very complex disease. So complex that very little has been discovered about it but that is rapidly changing. Findings from epidemiology, genetics, molecular and cell biology are fitting together in the Alzheimer's puzzle, helping researchers to identify some of the mechanisms that underlie it.
In Alzheimer’s disease, the tau proteins break loose from their normal location and form tangles. Without the support of these molecules, nerve cells collapse and die. As normal brain structure is lost with progression of the disease, brain function also degenerates. Patients afflicted with Alzheimer’s disease display a gradual mental decline. Initially, and most apparently, there is a loss of short-term memory.
Plaque is a deposit of protein mixed with fragments of dead or dying neurons found in the brains of patient who have Alzheimer’s. A tangle is a set of twisted nerve cell fibers found in the cell bodies of neurons in the brains of the patients who ha... ... middle of paper ... ...urrently incurable, and only two drugs--tacrine (Cognex) and donepezil hydrochloride (Aricept)-- have been approved by the FDA for its treatment. Several other drugs are being prescribed more often as their benefits are demonstrated in wider testing. Nonetheless, the mainstay of treatment for a person with Alazheimer’s continues to be good nursing care, providing both physical and emotional support for a person who is gradually able to do less and less for himself, and whose behavior is becoming more and more erratic. Modifications of the home to increase safety and security are often necessary.