Research Paper On Rabies

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nervous system. At this point in infection, the virus cannot be easily detected but vaccination may still help trigger cell-mediated immunity.
The average incubation period for rabies is one to three months, but may range from several days to many years after exposure. The incubation period is shorter in patients with an exposure in areas that contain a lot of nerves, such as the face, than areas like the extremities. Rabies begins with a period of non-specific symptoms, such as fever, chills, malaise, weakness, sore throat, headache, and vomiting. After this point, the infection may evolve into one of the two major forms of the disease, paralytic or furious. Occurring in 80% of cases, furious rabies is the more common. Productive replication of rabies occurs in areas of the body with high numbers of nerves, such as the salivary glands. Once the virus reaches the brain, it continues to replicate, eventually …show more content…

Following that, the patient may experience a paralysis that is prominent in the bitten limb and will then spread. Headaches and pain in the infected muscles follow, as well as mild sensory disturbances. Paralysis will ascend, causing lack of sensation in the muscles associated with swallowing and respiration, eventually leading to death.
Patients with encephalitic rabies, also referred to as furious rabies, may experience the following symptoms:
• Flu like symptoms that last for a few days, with discomfort or tingling at the site of the bite
• Hydrophobia (30-50% of patients), which begins with discomfort and difficulty swallowing and progresses to an overwhelming fear of water based on involuntary throat spasms when trying to drink. As the disease progresses, patients may even experience muscle spasms at the mere mention or sight of water
• Contracting facial muscles which may lead to the appearance of a grimace as well as a hyperextended back or neck

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