Omega 6 Essay

Anti-inflammatory effect of omega-6:
Recently, researchers challenged the dogma of omega-6 as pro-inflammatory, because they report that omega-6 fatty acids have both anti-inflammatory properties and pro-inflammatory properties [1, 4, 79].
Relevant cell observational tissue cultural studies: Omega-6 fatty acids have anti-inflammatory properties by inhibiting the production of interleukins, chemokines which reduces atherosclerosis progression [80]. Omega-6 has an anti-inflammatory effect by regulating PGE2 production from macrophages which inhibits TNF-α synthesis [7] and lipoxins formation [9]. Likewise, two studies found that PPARα expression in pretreated cultured human endothelial cells and human aortic smooth-muscle cells were significantly expressing the

However, lowering the consumption of pro-inflammatory SFAs and eliminating them from the food that we consume, may help lower the damaging consequence of these fats. Due to the competition between n-6 and n-3 fatty acids, both of them regulate each other, thus the balance of the n-6:n-3 ratio may be an important factor in determining physical and mental health. [23]. The American Heart Association recommends that people following the heart-healthy diet should consume 5% to 10% of their total calories intake from omega-6 fatty acids. AHA also recommends that the daily serving of omega-6 could range from 12-22 gm per day but this range is subject to age, gender and physical activity levels. Finally, AHA reported that many biological and conceptual limitations were found when researchers focus on the ratio between n-6: n-3 rather than the total intake of each type [94]; due to this reason, AHA did not state any recommendation based on the ratio