Ibuprofen: The ideal Non-Steroidal Anti-Inflammatory Drug?

1081 Words5 Pages
Ibuprofen is a medicine which has been available in the UK since 1969; it was discovered by scientists working for the Boots Company in the 1950s when looking for an alternative with fewer side effects than the commonly prescribed aspirin (The Royal Society of Chemistry, 2013). Ibuprofen belongs to a class of drugs known as Non-Steroidal Anti-Inflammatory drugs (NSAIDs) and is available as a Prescription only Medicine (POM), over the counter as a Pharmacy (P) medicine and in retail outlets as a General Sales List Medicine (GSL) (Royal Pharmaceutical Society, 2013). NSAIDs reduce temperature (antipyretic), are painkillers (analgesic) and have anti-inflammatory properties (Joint Formulary Committee, 2013). Figure 1 shows the chemical structure of ibuprofen. There are now twenty-one different NSAIDs available on the market; the drugs differ in their dose, interactions and side effects. This essay will look into many aspects of Ibuprofen to determine if it is the ideal NSAID. NSAIDs mode of action is to reduce the production of prostaglandins. Prostaglandins are hormones which trigger pain and inflammation in the immediate damaged area. NSAIDs inhibit an enzyme, Cyclo-Oxygenase (COX), which is involved in the first stage of prostaglandin production. There are two variants of this enzyme; COX-1 is responsible for the normal every day production of prostaglandins whereas COX-2 is responsible for production of additional prostaglandins when the body is injured as a natural defensive response. Non-selective NSAIDs, such as Ibuprofen, inhibit both COX-1 and COX-2 whereas selective NSAIDs; Celecoxib and Etoricoxib, inhibit only COX-2 (Society for Endocrinology, 2013; Ogbru, 2009). Ibuprofen is partially absorbed in the stomach and further ... ... middle of paper ... ...Formulary (BNF). (65th Ed.). London: BMJ Group and Pharmaceutical Press. Ogbru, O. (2009). COX-2 Inhibitors. FDA Prescribing Information. Retrieved January, 31, 2013, from http://www.medicinenet.com/cox-2_inhibitors/article.htm. Rang, H., Dale, M., Ritter, J., Flower, R., Henderson, G. (2013). Rang and Dale’s Pharmacology. (7th Ed.). China: Elsevier Churchill Livingstone. Royal Pharmaceutical Society. (2013). Medicines, Ethics and Practice: the professional guide for pharmacists. (37th Ed.). London: Pharmaceutical Press. The Royal Society of Chemistry. (2013). The Discovery of Ibuprofen. Retrieved December, 27, 2013, from http://www.rsc.org/learn-chemistry/resources/chemistry-in-your-cupboard/nurofen/7. Society for Endocrinology. (2013). Prostaglandins. You and your Hormones. Retrieved January, 1, 2014, from http://www.yourhormones.info/hormones/prostaglandins.aspx.

More about Ibuprofen: The ideal Non-Steroidal Anti-Inflammatory Drug?

Open Document